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Pregnancy-induced Cardiovascular Pathologies : Importance of Structural Components and Lipids

Pregnancy leads to adaptations for maternal and fetal energy needs. The cardiovascular system bears the brunt of the adaptations as the heart and vessels enable nutrient supply to maternal organs facilitated by the placenta to the fetus. The components of the cardiovascular system are critical in the balance between maternal homeostatic and fetus driven homeorhetic regulation. Since lipids interse

Evolution of MU69 from a binary planetesimal into contact by Kozai-Lidov oscillations and nebular drag

The New Horizons flyby of the cold classical Kuiper Belt object MU69 showed it to be a contact binary. The existence of other contact binaries in the 1–10 km range raises the question of how common these bodies are and how they evolved into contact. Here we consider that the pre-contact lobes of MU69 formed as a binary embedded in the Solar nebula, and calculate its subsequent orbital evolution in

Patterns in hospital readmissions after ischaemic stroke – An observational study from the Swedish stroke register (Riksstroke)

Introduction: While acute treatment and secondary prevention in stroke have undergone major improvements, hospital readmission after index stroke remains high. However, there are few reports on long-term readmission patterns. Patients and methods: For this prospective observational study, data on demographics, functional status and living conditions were obtained from the Swedish Stroke Register (

The impact of crowd composition on egress performance

The data that is currently used when designing egress systems for stadia and other high-occupancy buildings was collected decades ago and might not be applicable in today's society. A systematic analysis of crowd movement was performed to investigate egress flows at a large stadium in the UK following four different event types (i.e., a football game, a rugby game, a concert featuring a male singe

Decreased risk of ischemic heart disease in individuals with severe alpha 1-antitrypsin deficiency (PiZZ) in comparison with the general population

Background: Severe alpha-1-antitrypsin deficiency (AATD) is an established risk factor for chronic obstructive pulmonary disease (COPD) and liver disease, but the effect on the incidence of ischemic heart disease (IHD) is not well known. The aim was to evaluate the risk of incident IHD in patients with severe AATD compared with a random sample of the general population, with known smoking habits.

Nurses’ refusals of patient involvement in their own palliative care

Background: Ideas of patient involvement are related to notions of self-determination and autonomy, which are not always in alignment with complex interactions and communication in clinical practice.Aim: To illuminate and discuss patient involvement in routine clinical care situations in nursing practice from an ethical perspective.Method: A case study based on an anthropological field study amongBackground:Ideas of patient involvement are related to notions of self-determination and autonomy, which are not always in alignment with complex interactions and communication in clinical practice.Aim:To illuminate and discuss patient involvement in routine clinical care situations in nursing practice from an ethical perspective.Method:A case study based on an anthropological field study among pa

Hybrid tourist information search German tourists' combination of digital and analogue information channels

n a rapidly digitalizing world, both tourism actors and researchers are striving to keep pace with developments in tourist information search. This is not an easy task, as research results are pointing at different directions. Moreover, while tourism research is indicating the importance of analogue and digital information sources in parallel, tourism actors focus mainly on digital development. ThIn a rapidly digitalizing world, both tourism actors and researchers are striving to keep pace with developments in tourist information search. This is not an easy task, as research results are pointing at different directions. Moreover, while tourism research is indicating the importance of analogue and digital information sources in parallel, tourism actors focus mainly on digital development. T

Lysine-specific demethylase 1A (LSD1) restricts ex vivo propagation of human HSCs and is a target of UM171

Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator Lysine-specific histone demethylase 1A (LSD1) induces a rapid expansion of human cord blood derived CD34+ cells and promotes in vitro propagation of long-term repopulating HSCs by preventing differentiation. The phenot

On the validity of different methods to estimate breakup frequency from single drop experiments

Single drop breakup visualizations are the golden standard for experimentally measuring breakup frequency, g, in turbulent flows. There is a growing demand for empirically obtained breakup frequencies, for population balance equation (PBE) based predictive modelling and for comparing to theoretical suggestions. However, five different methods to estimate g from a breakup visualization can be found

Ecological opportunity and upward prey-predator radiation cascades

A general goal in community ecology and evolutionary biology is to understand how diversity has arisen. In our attempts to reach such goals we become increasingly aware of interacting ecological and evolutionary processes shaping biodiversity. Ecological opportunity and adaptive radiations can, for example, drive diversification in competitive communities but little is known about how such process

Mercury as a Geophysical Tracer Gas - Emissions from the Emperor Qin Tomb in Xi´an Studied by Laser Radar

Mercury is, because of its high vapor pressure and its prevalence in the atmosphere as atoms, an interesting geophysical tracer gas, also with potential archaeological applications. According to historical records dating back 2200 years, the mausoleum chamber of the “Terracotta Army Emperor” Qin in Xi´an, China, contains large amounts of liquid mercury, considered as an elixir of life at the time.

Additive clinical impact of epidermal growth factor receptor and podocalyxin-like protein expression in pancreatic and periampullary adenocarcinomas

The outcome of periampullary adenocarcinomas remains poor with few treatment options. Podocalyxin-like protein (PODXL) is an anti-adhesive protein, the high expression of which has been shown to confer a poor prognosis in numerous malignancies. A correlation and adverse prognostic synergy between PODXL and the epidermal growth factor receptor (EGFR) has been observed in colorectal cancer. Here, we

The association between Single Nucleotide Polymorphisms of Klotho Gene and Mortality in Elderly Men : The MrOS Sweden Study

The Klotho (KL) gene is involved in phosphate homeostasis. Polymorphisms in this gene have been reported to be associated with the risk of cardiovascular disease. Here we used computational tools to predict the damage-associated single nucleotide polymorphisms (SNPs) in the human KL gene. We further investigated the association of SNPs in the KL gene and mortality in the Swedish multicenter prospe

INSIDE : An efficient guide for sustainable remediation practice in addressing contaminated soil and groundwater

Modeling criteria interaction in decision-making problems is complex and often neglected. In complicated problems, like contaminated site remediation projects, independency of involved criteria is not a realistic assumption. INfluence based deciSIon guiDE (INSIDE) is a methodology that enables sustainable decision making and management in contaminated site remediation practice. Unlike most previou

A Scheimpflug lidar used to observe insect swarming at a wind turbine

Wind turbines have considerable impact on flying animals, particularly bats, which are sometimes killed in large numbers by the moving rotors. A longstanding question remains why bats are attracted to wind turbines and risk their lives among the moving rotor blades. One hypothesis is that they feed on insects swarming around the turbine towers and another is that they congregate there to court. Th

Structure and propagation of n-heptane/air premixed flame in low temperature ignition regime

This paper presents a large eddy simulation of n-heptane/air turbulent premixed combustion in a reactor assisted turbulent slot (RATS) burner under different preheating conditions. N-heptane/air mixture at an equivalence ratio of 0.6, pressure of 1 atm and temperature of 600, 650 and 700 K is considered to investigate the effect of low temperature chemistry on turbulent burning velocities and flam

An investigation of the enzymatic cleavage of κ-casein in non-coagulating milk

Non-coagulating milk is unwanted in cheese production because it impairs chymosin-induced coagulation properties in bulk milk. Milk samples were analysed to investigate the coagulation process in non-coagulating milk for comparison with milk samples that have a high coagulation ability. This was done by measuring two peptides after chymosin cleavage, namely para-κ-casein and caseinomacropeptide, i