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Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin.

Huntington disease is a neurodegenerative disorder caused by an expanded CAG repeat in the Huntington disease gene. The symptomatic phase of the disease is defined by the onset of motor symptoms. However, psychiatric disturbances, including depression, are common features of Huntington disease and recent studies indicate that depression can occur long before the manifestation of motor symptoms. Th

Consistent stiffness matrix in FE calculations of elasto-plastic bodies

In order to preserve the quadratic convergence of the Newton-Raphson method applied to elasto-plastic finite element calculations, the consistent stiffness matrix must be used. Here, the consistent stiffness matrix is derived for the generalized trapezoidal rule. Special attention is paid to the case in which the integration is performed from an elastic to an elasto-plastic state and it is shown t

Do we Still Need Human Embryonic Stem Cells for Stem Cell-Based Therapies? Epistemic and Ethical Aspects.

While scientific community disagrees about similarities and differences between human embryonic stem (hES) cells and human induced pluripotent stem (hiPS) cells, some politicians embrace translational hiPS cell research as a replacement for translational hES cell research. We examine the ethical relevance of the main differences between hES and hiPS cell-based therapies and discuss whether, given

Interim Buprenorphine Treatment in Opiate Dependence: A Pilot Effectiveness Study.

Interim methadone treatment (i.e. temporary medication-only treatment) has been tested in a few US studies as a method for facilitated referral to and initiation of opioid maintenance treatment in heroin dependence. However, despite the favorable safety profile of buprenorphine compared to methadone, interim treatment with buprenorphine rarely has been tested and reported in the scientific literat

Overproduction of PIB-Type ATPases.

Understanding of the functions and mechanisms of fundamental processes in the cell requires structural information. Structural studies of membrane proteins typically necessitate large amounts of purified and preferably homogenous target protein. Here, we describe a rapid overproduction and purification strategy of a bacterial PIB-type ATPase for isolation of milligrams of target protein per liter

Two-tone frequency-modulation spectroscopy for quantitative measurements of gaseous species: Theoretical, numerical, and experimental investigation of line shapes

The capability of retrieving spectral information from line shapes recorded by two-tone frequency-modulation spectroscopy (TTFMS) is investigated. A TTFMS theory accounting for dispersion and nonlinear distortion of diode laser frequency modulation response is presented. The adequacy of the theory for a detailed modeling of line shapes recorded with high resolution is examined. An extensive error

Histopathological findings and follow-up after prophylactic mastectomy and immediate breast reconstruction in 100 women from families with hereditary breast cancer.

AIM: To survey the histopathological abnormalities in breasts of women who have undergone risk reducing mastectomy and to evaluate the effect of this measure on future breast cancer development. PATIENTS/METHODS: Between August 1995 and October 2006 100 consecutive women with a hereditary increased risk of breast cancer underwent prophylactic mastectomy (PM) at Malmö University Hospital. Fifty of

An ecological model for the processing of symbolic information

This article attempts to prove that an adequate cognition oriented approach to the processing of symbolic information abstracted from verbal expressions must consider a running text instead of scattered sentences. It is argued that the dominant cognition models do not give due consideration to the fact that a valid abstraction of in-formation structures has to be based on an explicit encoding of i

Binding and Release of Consensus Peptides by Poly(acrylic acid) Microgels.

The interaction between positively charged consensus peptides and poly(acrylic acid) microgels was investigated with micromanipulator-assisted light microscopy and confocal laser scanning microscopy. Peptide binding and release was monitored by microgel deswelling and swelling for monodisperse multiples of heparin-binding Cardin and Weintraub motifs, (AKKARA)(n) (1

The Accuracy of Short Clinical Rating Scales in Neuropathologically Diagnosed Dementia.

OBJECTIVE:: The overall aim was to evaluate to what extent the diagnosis of dementia subtypes, obtained by three clinical rating scales, concurred with postmortem neuropathologic (NP) diagnosis of Alzheimer disease (AD), frontotemporal dementia (FTD), vascular dementia (VaD) and mixed AD/VaD. DESIGN:: A prospective longitudinal clinical work-up with postmortem NP examination. PARTICIPANTS:: Two hu

Genitals and ethnicity: the politics of genital modifications.

The discrepancy in societal attitudes toward female genital cosmetic surgery for European women and female genital cutting in primarily African girl children and women raises the following fundamental question. How can it be that extensive genital modifications, including reduction of labial and clitoral tissue, are considered acceptable and perfectly legal in many European countries, while those