Sökresultat

Filtyp

Din sökning på "*" gav 528910 sökträffar

Interim Buprenorphine Treatment in Opiate Dependence: A Pilot Effectiveness Study.

Interim methadone treatment (i.e. temporary medication-only treatment) has been tested in a few US studies as a method for facilitated referral to and initiation of opioid maintenance treatment in heroin dependence. However, despite the favorable safety profile of buprenorphine compared to methadone, interim treatment with buprenorphine rarely has been tested and reported in the scientific literat

Overproduction of PIB-Type ATPases.

Understanding of the functions and mechanisms of fundamental processes in the cell requires structural information. Structural studies of membrane proteins typically necessitate large amounts of purified and preferably homogenous target protein. Here, we describe a rapid overproduction and purification strategy of a bacterial PIB-type ATPase for isolation of milligrams of target protein per liter

Two-tone frequency-modulation spectroscopy for quantitative measurements of gaseous species: Theoretical, numerical, and experimental investigation of line shapes

The capability of retrieving spectral information from line shapes recorded by two-tone frequency-modulation spectroscopy (TTFMS) is investigated. A TTFMS theory accounting for dispersion and nonlinear distortion of diode laser frequency modulation response is presented. The adequacy of the theory for a detailed modeling of line shapes recorded with high resolution is examined. An extensive error

Histopathological findings and follow-up after prophylactic mastectomy and immediate breast reconstruction in 100 women from families with hereditary breast cancer.

AIM: To survey the histopathological abnormalities in breasts of women who have undergone risk reducing mastectomy and to evaluate the effect of this measure on future breast cancer development. PATIENTS/METHODS: Between August 1995 and October 2006 100 consecutive women with a hereditary increased risk of breast cancer underwent prophylactic mastectomy (PM) at Malmö University Hospital. Fifty of

An ecological model for the processing of symbolic information

This article attempts to prove that an adequate cognition oriented approach to the processing of symbolic information abstracted from verbal expressions must consider a running text instead of scattered sentences. It is argued that the dominant cognition models do not give due consideration to the fact that a valid abstraction of in-formation structures has to be based on an explicit encoding of i

Binding and Release of Consensus Peptides by Poly(acrylic acid) Microgels.

The interaction between positively charged consensus peptides and poly(acrylic acid) microgels was investigated with micromanipulator-assisted light microscopy and confocal laser scanning microscopy. Peptide binding and release was monitored by microgel deswelling and swelling for monodisperse multiples of heparin-binding Cardin and Weintraub motifs, (AKKARA)(n) (1

The Accuracy of Short Clinical Rating Scales in Neuropathologically Diagnosed Dementia.

OBJECTIVE:: The overall aim was to evaluate to what extent the diagnosis of dementia subtypes, obtained by three clinical rating scales, concurred with postmortem neuropathologic (NP) diagnosis of Alzheimer disease (AD), frontotemporal dementia (FTD), vascular dementia (VaD) and mixed AD/VaD. DESIGN:: A prospective longitudinal clinical work-up with postmortem NP examination. PARTICIPANTS:: Two hu

Genitals and ethnicity: the politics of genital modifications.

The discrepancy in societal attitudes toward female genital cosmetic surgery for European women and female genital cutting in primarily African girl children and women raises the following fundamental question. How can it be that extensive genital modifications, including reduction of labial and clitoral tissue, are considered acceptable and perfectly legal in many European countries, while those

Plastic effects of L-DOPA treatment in the basal ganglia and their relevance to the development of dyskinesia.

The development of L-DOPA-induced dyskinesia (LID) is attributed to plastic responses triggered by dopamine (DA) receptor stimulation in the parkinsonian brain. This article reviews studies that have uncovered different levels of maladaptive plasticity in animal models of LID. Rats developing dyskinesia on chronic L-DOPA treatment show abnormal patterns of signaling pathway activation and synaptic

Hybrid Microdevice Electrophoretic of Peptides, Proteins, DNA, Viruses and Bacteria in Various Separations Media Using UV-Detection

Recently we described the design of a hybrid microdevice for micro(nano)electrophoresis and electrochromatography, discussed its advantages and disadvantages compared to conventional microdevices and presented a few applications with lowmolecular-weight samples. In this paper, we demonstrate the broad application range of this device using UV-based analyses of (i) peptides by free-zone electrophor

How mental health literacy and experience of mental illness relate to stigmatizing attitudes and social distance towards people with depression or psychosis: A cross-sectional study.

Background Evidence suggests that mental health literacy among the public is low, and stigmatizing attitudes are widespread. So far the effects of anti-stigma campaigns are small, and studies demonstrate that negative attitudes have been quite stable through recent decades. Aims To investigate the relationships between mental health literacy, experience of mental illness and stigmatizing attitudes

Pulmonary intravascular blood volume changes through the cardiac cycle in healthy volunteers studied by cardiovascular magnetic resonance measurements of arterial and venous flow.

BACKGROUND: This study aims to present a novel method for using cardiovascular magnetic resonance (CMR) to non-invasively quantify the variation in pulmonary blood volume throughout the cardiac cycle in humans. METHODS: 10 healthy volunteers (7 males, 3 female, age range 21-32 years) were studied. The blood flow in the pulmonary artery and all pulmonary veins was quantified during free breathing u

Natural Lifetimes of Excited-states of Neutral Nitrogen Determined By Time-resolved Laser Spectroscopy

Radiative lifetimes were determined for three quartet states of neutral nitrogen, and sequences of Rydberg states were studied using depletion spectroscopy. Free nitrogen atoms were generated by photodissociation of N2O using frequency-tripled dye-laser radiation that was two-photon resonant with the 2p(2)3p 4S or 4D states. Further quartet states were reached by a subsequent single-photon absorpt