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Callous-Unemotional Traits, Harm-Effect Moral Reasoning, and Bullying Among Swedish Children

Background: Although callous-unemotional (CU) traits have been associated with bullying among children and adolescents, relatively little is known about whether each of the three sub-constructs of CU traits—callous, uncaring, and unemotional—are associated with bullying when they are considered concurrently in the analysis. Objective: This study was the first to examine in a single model whether c

Routine coagulation tests on ICU admission are associated with mortality in sepsis : an observational study

Background: Low platelet count on admission to an intensive care unit (ICU) is associated with increased mortality and is thus included in some severity scoring systems such as the simplified acute physiologic score 3 (SAPS 3); however it is unclear whether other routine coagulation tests also predict mortality. The purpose of this retrospective single-centre study was to investigate whether activ

Comparison of citrated and fresh whole blood for viscoelastic coagulation testing during elective neurosurgery

Background Previous viscoelastic haemostatic tests studies have often indicated a hypercoagulative test signal with citrated blood, which could influence clinical decision makings. Purpose The aim of this study was to compare fresh and citrated whole blood using two non-automated viscoelastic ROTEM and Sonoclot tests. Our hypothesis was that citrated blood would demonstrate a hypercoagulative resp

Changing management of gallstone-related disease in pregnancy–a retrospective cohort analysis

Objectives: Gallstone-related disease is the second most common non-obstetric cause, following appendicitis, for acute abdomen in pregnancy. This study aimed to investigate treatment strategies, changes over time and outcome. Materials and methods: All consecutive patients with symptomatic gallstone-related disease during pregnancy admitted to Skane University hospital in Lund and Malmö 2001–2015

Coagulative safety of epidural catheters after major upper gastrointestinal surgery : advanced and routine coagulation analysis in 38 patients

BACKGROUND: The risk of spinal haematoma in patients receiving epidural catheters is estimated using routine coagulation tests, but guidelines are inconsistent in their recommendations on what to do when results indicate slight hypocoagulation. Postoperative patients are prone to thrombosis, and thromboelastometry has previously shown hypercoagulation in this setting. We aimed to better understand

Intraductal papillary mucinous neoplasm of the pancreas–epidemiology, risk factors, diagnosis, and management

Intraductal papillary mucinous neoplasm (IPMN) is one of the most common cystic neoplasms of the pancreas. It is a heterogeneous disease and can be divided into ductal types and morphological subtypes. The incidence of IPMN is increasing, likely due to the widespread use of cross-sectional imaging and a growing elderly population. IPMN poses an increasing demand on the health care system. Current

Capsule retention related to small bowel capsule endoscopy : a large European single-center 10-year clinical experience

Background: The most concerning complication of video capsule endoscopy (VCE) is capsule retention (CR) in the gastrointestinal (GI) tract although clinical outcome and management of patients with CR are still uncertain in a large single center material. Objectives: The aim of this retrospective study was to investigate incidence, causes, risk factors, management and clinical outcomes of CR in a l

Apolipoprotein M increases the expression of Vitamin D receptor mRNA in colorectal cancer cells detected with duplex fluorescence reverse transcription-quantitative polymerase chain reaction

Apolipoprotein M (ApoM) and the Vitamin D receptor (VDR) are apolipoproteins predominantly presenting in high-density lipoprotein (HDL) and a karyophilic protein belonging to the steroid-thyroid receptor superfamily, respectively. Previous studies have demonstrated that ApoM and VDR are associated with cholesterol metabolism, immune and colorectal cancer regulation. In order to investigate whether

Vulnerability reduction needed to maintain current burdens of heat-related mortality in a changing climate—magnitude and determinants

The health burden from heatwaves is expected to increase with rising global mean temperatures and more extreme heat events over the coming decades. Health-related effects from extreme heat are more common in elderly populations. The population of Europe is rapidly aging, which will increase the health effects of future temperatures. In this study, we estimate the magnitude of adaptation needed to

A core undergraduate curriculum in plastic surgery – a Delphi consensus study in Scandinavia

Background and aims: In recent years, undergraduate medical education has undergone a transition from a speciality-based to a more competence-based training system. Consequently, whilst medical knowledge is rapidly expanding, time for teaching of the surgical specialties is decreasing. Thus, there appears to be a need to define the core competences that are to be taught. The aim of this study was

Nineteen Victims of Homicide and Attempted Homicide in Sweden—Their Injuries, Cause of Death, and Offender Relationship

ABSTRACT: Victims of homicide and attempted homicide are not uncommon in Sweden. We therefore aimed to study these victims to understand their injuries, their cause of death, and their relationship to the offender. All cases during five years in a district court in Sweden, where an offender had been convicted for homicide or attempted homicide, were identified and the court documents reviewed. Nin

Effect of dextran-70 on outcome in severe sepsis; A propensity-score matching study

Background: Albumin may be beneficial in patients with septic shock but availability is limited and cost is high. The objective of the present study was to investigate if the use of dextran-70 in addition to albumin and crystalloids influences organ failure or mortality in patients with severe sepsis or septic shock. Methods: Patients with severe sepsis or septic shock (n = 778) admitted to a univ

Three-year data from 5 HARMONY phase 3 clinical trials of albiglutide in type 2 diabetes mellitus : Long-term efficacy with or without rescue therapy

Aims Diabetes therapies that provide durable glycaemic control for people with type 2 diabetes mellitus (T2DM) are needed. We present efficacy results of albiglutide, a glucagon-like peptide-1 receptor agonist, in people with T2DM over a 3-year period. Methods Five of the 8 HARMONY phase 3 trials, comparing albiglutide with other therapies or placebo across a spectrum of clinical care, lasted for

Experimental and Numerical Aspects of a Thermal Fluid-Structure Phenomenon

A fundamental research experiment for thermal fluid-structure-interaction for the verification of a partitioned approach with non-linear material properties is examined. In the following, a specimen is heated as well as cooled within a wind tunnel. The thermal fluid-structure-interaction is first experimentally investigated and subsequently numerically validated. For the numerical simulation, two

Adopting (s)EPIRK schemes in a domain-based IMEX setting

The simulation of viscous, compressible flows around complex geometries or similar applications often inherit the task of solving large, stiff systems of ODEs. Domain-based implicit-explicit (IMEX) type schemes offer the possibility to apply two different schemes to different parts of the computational domain. The goal hereby is to decrease the computational cost by increasing the admissible step

Making Research Matter More—Working with Action Research and Film in Sustainability Science

Advocacy for both critical analysis of social and environmental change and a more solutions-oriented agenda has been a central mission of sustainability science since its inception [1]. To this end, integration of knowledge across disciplinary divides and inclusion of non-academic actors into the research process have been widely promoted (e.g. [2–4]). Aspirations to link knowledge to action do no