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Digital background calibration in continuous-time delta-sigma analog to digital converters

This work presents a digital calibration technique in continuous-time (CT) ΔΣ analog to digital (A/D) converters. The converter is clocked at 144MHz with a low oversampling ratio (OSR) of only 8. Dynamic element matching (DEM) is not efficient to linearize the digital to analog converter (DAC) when the OSR is very low. Therefore, non-idealities in the outermost multi-bit feedback DAC are measured

Film International Issue 36 : Sex in the Cinema

A themed journal issue which contains six commissioned essays + an editorial about the phenomenon of sex in the cinema, television and on the internet since the historical breakthrough of sex research by Alfred C. Kinsey in the late 1940s. The essays span a wide array of topics including, to name a few, the developments within obscenity law in the US, sex in the work of European art cinema auteurs

Nursing and multidisciplinary interventions for Parkinson's disease: what is the evidence?

This paper reports the interim results of an ongoing systematic review of the available evidence for the effectiveness of nursing care for people with Parkinson's disease (PD). Five clinical and four health-economic evaluations suggest that the clinical and cost effectiveness of nursing care for PD remain inconclusive. This is in contrast to clinical experience and may be due to issues related to

Sugar-free antibodies--the bacterial solution to autoimmunity?

The enzyme EndoS from Streptococcus pyogenes is an immunomodulatory molecule hydrolyzing the conserved glycans in the effector part of immunoglobulin G (IgG). EndoS is remarkably specific for IgG, and hydrolysis has profound effects on IgG effector functions. EndoS pretreatment of IgG, or direct administration to animals with experimental antibody-mediated autoimmune diseases, inhibits development

G Protein-Coupled Receptor 39 Deficiency Is Associated with Pancreatic Islet Dysfunction

G protein-coupled receptor (GPR)-39 is a seven-transmembrane receptor expressed mainly in endocrine and metabolic tissues that acts as a Zn++ sensor signaling mainly through the G(q) and G(12/13) pathways. The expression of GPR39 is regulated by hepatocyte nuclear factor (HNF)-1 alpha and HNF-4 alpha, and in the present study, we addressed the importance of GPR39 for glucose homeostasis and pancre

MYBPC3 hypertrophic cardiomyopathy can be detected by using advanced ECG in children and young adults

Introduction The conventional ECG is commonly used to screen for hypertrophic cardiomyopathy (HCM), but up to 25% of adults and possibly larger percentages of children with HCM have no distinctive abnormalities on the conventional ECG, whereas 5 to 15% of healthy young athletes do. Recently, a 5-min resting advanced 12-lead ECG test ("A-ECG score") showed superiority to pooled criteria from the st

WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast cancer cells

An important role for WNT-5A is implicated in a variety of tumors, including breast carcinoma. We previously showed that WNT-5A signaling inhibits migration and metastasis of breast cancer cells, and that patients with primary breast cancer in which WNT-5A was expressed have a better prognosis. Despite the fact that RhoGTPase Cdc42 is commonly associated with increased cell migration, we here show

The Democratic Legitimacy of Refugee Law

Having left their home country, 18 million refugees and other protection seekers cannot exert their rights to democratic participation. As a consequence, they are deprived of all influence on a legal instrument of existential importance for them, namely the grant of asylum. Can the exclusion of refugees from the framing of aliens legislation be justified?The analysis carried out in this text proce

Affirmative Exclusion? Sex, Gender, Persecution and the Reformed Swedish Aliens Act

The revised version of the Swedish Aliens Act contains a specific category providing protection for persons who fear persecution on account of their sex. Benefits afforded under this category, however, fall short of those under the 1951 Convention relating to the Status of Refugees or article 3 of the European Convention for the Protection of Human Rights and Fundamental Freedoms. In order to eval

The ethics of palliative sedation in children

At the end of life, when cure or meaningful prolongation of life is no longer available, relief of suffering is the overriding goal. In certain circumstances standard treatments may fall short of this goal, and palliative sedation (PS) to unconsciousness can be applied as a ultimum refugium.We cared for a 4-year old boy with a brain-stem tumor. In spite of all curative treatment efforts the tumor

Strict Ethics Regulation Without Appropriate Institutional Implementation Won’t Protect Decisionally Incapacitated Research Subjects: Lessons fom Sweden

The standard requirement of informed consent cannot be met when potential research subjects are decisionally incapacitated due to e.g. dementia, intellectual disabilities, or other mental health problems. Such research subjects are generally recognized as being in need of special protection, particularly when the relevant research cannot be expected to benefit the participating individuals themsel