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Structural optimisation of diffusion driven degradation processes

In this article, we propose an optimisation framework that can contribute to the prevention of premature failure or damage to building structures and can thereby strengthen their longevity. We concentrate on structures that are contaminated by chemical substances and that have strong destructive effects on the material. The aim of this contribution is a mathematical algorithm that allows the optim

Short-term outcomes following beyond total mesorectal excision and reconstruction using myocutaneous flaps : A retrospective cohort study

Introduction: Beyond total mesorectal excision (bTME) offers long-term survival in patients with advanced pelvic malignancy. At Skåne University Hospital (SUS) Malmö in Sweden, the vertical rectus abdominis musculocutaneous (VRAM) and gluteal maximus (GM) flap have been used for perineal reconstruction to promote healing and functional outcomes after significant tissue loss. This study aims to exa

Derivation of Adult Human Cortical Organotypic Slice Cultures for Coculture with Reprogrammed Neuronal Cells

Adult human cortical organotypic slice culture is an attractive model system to explore mechanisms of human brain pathology as well as to test drug candidates for treatment of neurodegeneration. Acute studies in human brain slices are limited by the lifetime of the tissue and focus mainly on hippocampus slice preparation. Here we describe the derivation of human organotypic slice cultures of corti

Experimental Evaluation of Physical Breast Phantoms for 2D and 3D Breast X-Ray Imaging Techniques

Anthropomorphic phantoms are models of real or virtual parts of the body, organ or tissue, represented by tissue-equivalent materials that aim to provide a realistic and accurate representation of their anatomy and properties. The aim of this study is to evaluate experimentally the suitability of 3D printed materials in the production of both, physical breast phantoms and abnormalities, to be used

Clinical validity of increased cortical binding of tau ligands of the THK family and PBB3 on PET as biomarkers for Alzheimer’s disease in the context of a structured 5-phase development framework

Purpose: The research community has focused on defining reliable biomarkers for the early detection of the pathological hallmarks of Alzheimer’s disease (AD). In 2017, the Geneva AD Biomarker Roadmap initiative adapted the framework for the systematic validation of oncological biomarkers to AD, with the aim to accelerate their development and implementation in clinical practice. The aim of this wo

Blood, sugar, breath

An full concert including the following comprovisations: ABC, Frictional, PulLingBils, Criptomelodie, Crazy gambling witch doctor, and others.

Effects of Abstinence Self-Efficacy and Coping on Substance Use Among Homeless Youth

Homeless youth are a vulnerable and understudied group who hasconsistently reported elevated levels of substance use. Understanding the factors associated with substance use within this population may help guide future intervention efforts. Although few studies have examined the role of abstinence self-efficacy and coping in substance use among homeless youth, some research indicates that higher a

Mental Health Problems Among Adolescents in Sweden from 1995 to 2011 : The Role of Immigrant Status and the Proportions of Immigrant Adolescents in Their Surrounding Community

We compared the mental health of native and immigrant adolescents in Sweden from 1995 to 2011 and examined whether the municipality-level proportion of immigrant adolescents moderated the association between individual-level immigrant status and mental health. The sample (14,189 adolescents aged 15-16) was obtained from a repeated cross-sectional study conducted from 1995 to 2011. Adolescent self-

Agonistic interaction in practice : laughing, dissensus and hegemony in the Northern Ireland Assembly

The 1998 Agreement in Northern Ireland has often been portrayed as a textbook example of agonistic peace allowing parties to continue conflict in a political, adversarial manner post accord. Here, I investigate the institutional and dialogical reality of this claim by scrutinising agonistic aspects of interaction occurring in the Northern Ireland Assembly. Specifically, I analyse a video recording

CRISPR/Cas9 Genome Engineering in Human Pluripotent Stem Cells for Modeling of Neurological Disorders

Recent advances in genome editing have brought new hopes for personalized and precision medicine but have also dramatically facilitated disease modeling studies. Combined with reprogramming approaches, stem cells and differentiation toward neural lineages, genome engineering holds great potential for regenerative approaches and to model neurological disorders. The use of patient-specific induced p

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An comprovisation on Criptomelodie infantili by Demetrio Stratos.

A Framework-Based Approach to Assessing Mental Health Impacts of the COVID-19 Pandemic on Children and Adolescents

The COVID-19 pandemic has yielded extensive impacts globally in the year of 2020. Although the mental health of children and adolescents may be particularly susceptible to stressors stemming from the pandemic and anti-contagion policies, most ongoing efforts are geared toward curbing the viral spread. In the current perspective, we have identified four domains of factors corresponding to an ecolog