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Automated artificial intelligence-based analysis of skeletal muscle volume predicts overall survival after cystectomy for urinary bladder cancer

Background: Radical cystectomy for urinary bladder cancer is a procedure associated with a high risk of complications, and poor overall survival (OS) due to both patient and tumour factors. Sarcopenia is one such patient factor. We have developed a fully automated artificial intelligence (AI)-based image analysis tool for segmenting skeletal muscle of the torso and calculating the muscle volume. M

Subjective experience of speech depending on the acoustic treatment in an ordinary room

In environments such as classrooms and offices, complex tasks are performed. A satisfac-tory acoustic environment is critical for the performance of such tasks. To ensure a good acoustic environment, the right acoustic treatment must be used. The relation between different room acoustic treatments and how they affect speech perception in these types of rooms is not yet fully under-stood. In this s

An integrated continuous downstream process with real-time control : A case study with periodic countercurrent chromatography and continuous virus inactivation

Integrated continuous downstream processes with process analytical technology offer a promising opportunity to reduce production costs and increase process flexibility and adaptability. In this case study, an integrated continuous process was used to purify a recombinant protein on laboratory scale in a two-system setup that can be used as a general downstream setup offering multiproduct and multi

Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer

Analysis of the genomic landscape of prostate cancer has identified different molecular subgroups with relevance for novel or existing targeted therapies. The recent approvals of the poly(ADP-ribose) polymerase (PARP) inhibitors olaparib and rucaparib in the metastatic castration-resistant prostate cancer (mCRPC) setting signal the need to embed molecular diagnostics in the clinical pathway of pat

Effect of aluminum on microstructure and properties of martensitic wear-resistant and heat-resistant steel

The effect of aluminum on microstructure and properties of martensitic wear-resistant and heat-resistant steels was investigated. The results indicate that as-cast microstructure of the specimens is composed of ferrite, pearlite and carbides. After quenching at 1,000 C and tempering at 600 C, the microstructure of the specimens consists of tempered sorbite and Fe-Cr-Al intermetallic compounds whic

Secondary structure in de novo designed peptides induced by electrostatic interaction with a lipid bilayer membrane

We show that it is possible to induce a defined secondary structure in de novo designed peptides upon electrostatic attachment to negatively charged lipid bilayer vesicles without partitioning of the peptides into the membrane, and that the secondary structure can be varied via small changes in the primary amino acid sequence of the peptides. The peptides have a random-coil conformation in solutio

High levels of expression of cartilage oligomeric matrix protein in lymph node metastases in breast cancer are associated with reduced survival

Cartilage oligomeric matrix protein (COMP) is a regulator of the extracellular matrix and is expressed primarily in the cartilage. Recently, COMP expression was also documented in breast cancer patients both in sera and tumor biopsies, in both of which it could serve as an independent prognostic marker. This study aimed to assess COMP as a potential biomarker in the group of metastatic breast canc

Long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery for epithelial ovarian cancer

Objective: The aim of this study was to investigate long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery (FSS) to verify the feasibility of the limited surgery for epithelial ovarian cancer (OvCa). Study design: We performed a regional multicenter retrospective study from January 1986 and March 2020, using clinical data corrected under the central patholog

Relationship Between Magnetic Resonance Imaging Features and Knee Pain Over Six Years in Knees Without Radiographic Osteoarthritis at Baseline

Objective: To explore whether magnetic resonance imaging (MRI) features suggestive of knee osteoarthritis (OA) are associated with presence of knee pain in possible early-stage OA development. Methods: We included 294 participants from the Osteoarthritis Initiative (mean ± SD age 50 ± 3 years; 50% women) with baseline Kellgren/Lawrence grade of 0 in both knees, all of whom had received knee MRIs a

New Distinguisher on Reduced-Round Keccak Sponge Function

The security analysis of Keccak, the winner of SHA-3, has attracted considerable interest. Recently, some attention has been paid to distinguishing Keccak sponge function from random permutation. In EUROCRYPT'17, Huang et al. proposed conditional cube tester to recover the key of Keccak-MAC and Keyak and to construct practical distinguishing attacks on Keccak sponge function up to 7 rounds. In thi

Platelets in ITP : Victims in charge of their own fate?

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. The pathophysiological mechanisms leading to low platelet levels in ITP have not been resolved, but at least involve autoantibody-dependent and/or cytotoxic T cell mediated platelet clearance and impaired megakary-opoiesis. In addition, T cell imbalances involving T regulatory cells (Tregs) also appear to play an important role. Int

The effect of sociodemographic factors, parity and cervical cancer on antibiotic treatment for uncomplicated cystitis in women : A nationwide cohort study

Background: Uncomplicated cystitis is one of the most common reasons for antibiotic treatment in otherwise healthy women. Nationwide studies on antibiotic treatment for this infection and in relation to factors beyond the infection itself have hitherto not been available. Methods: This was a nationwide open cohort study consisting of 352,507 women aged 15–50 years with uncomplicated cystitis (2006

Pain management with methoxyflurane (Penthrox®) in Swedish ambulance care – An observational pilot study

Background: In ambulance care, patients are often classified as high-risk, particularly when they are in immediate need of pain relief. It has been shown that, after ambulance nurses administer intravenous analgesic drugs, patients delivered to the emergency department tend to complain of moderate to severe pain. Aims and objectives: The present study aimed to evaluate the overall patient-perceive

The relative importance of determinants of the solar photovoltaic industry in china : Analyses by the diamond model and the analytic hierarchy process

Within China’s renewable energy industry, the importance of the solar photovoltaic industry has been increasingly recognized. Many Chinese provinces have adopted various measures to develop the solar photovoltaic industry. This study used the diamond model and the analytic hierarchy process to clarify the relative importance of the determinants of the development of the solar photovoltaic industry