Objectives Our aim was to use the opportunity provided by the European Scleroderma Observational Study to (1) identify and describe those patients with early diffuse cutaneous systemic sclerosis (dcSSc) with progressive skin thickness, and (2) derive prediction models for progression over 12 months, to inform future randomised controlled trials (RCTs). Methods The modified Rodnan skin score (mRSS)

Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship b

The literature on regional innovation systems emphasizes the role of the region as locus for interactive learning and knowledge exchange, stressing the importance of (geographical) proximity for innovation. Even though the importance of extra-regional knowledge is widely acknowledged, there has been only little emphasis on the particular role and the nature of global knowledge flows. The aim of th

Seven native residues on the regulatory protein calmodulin, including three key methionine residues, were replaced (one by one) by the vibrational probe amino acid cyanylated cysteine, which has a unique CN stretching vibration that reports on its local environment. Almost no perturbation was caused by this probe at any of the seven sites, as reported by CD spectra of calcium-bound and apo calmodu

We analyse the effect of business model innovation (BMI) on the product innovation performance of firms, based on a dynamic capabilities theoretical framework. Our empirical study is based on a large-scale representative sample of cross-industry Swedish firms participating in three waves of the Community Innovation Survey (CIS) from 2008 to 2012. We hypothesise that BMI in the form of product inno

En handskrift som en gång tillhörde Alvastra kloster, nu Uppsala Universitetsbibliotek C 37, innehåller en delvis kalendariskt ordnad predikosamling nedskriven i början av 1200-talet, utan kända paralleller. Artikeln beskriver samlingen och konstaterar att innehållet har både monastisk och folklig prägel. En möjlig slutsats är att en munk i Alvastra har sammanställt/författat predikningarna för at

The design of antennas for compact multiple-input multiple-output (MIMO) terminals is a challenging feat, due to the space constraint and the physical structure of the terminal. The space constraint forces the antennas to be closely spaced, which degrades MIMO performance due to high signal correlation and low antenna efficiency. Moreover, the terminals are equipped with ground planes which furthe

Popular Abstract in Swedish Alla levande organismer har DNA, och eftersom DNA är livsnödvändigt måste det repareras om det blir skadat. Ultraviolett (UV) strålning från solen är en av de vanligaste orsakerna till att DNA skadas. De flesta skador på DNA som orsakas av UV-strålning utgörs av cyklobutan-pyrimidindimerer (CPD) eller (6-4)-fotoprodukter. Dessa skador består av två intilliggande baser sAll living organisms have DNA and since DNA is essential to life it must be repaired when damaged. UV radiation is one of the major DNA damaging agents, which photosynthetic organisms cannot avoid. The major UV-induced DNA lesions are cyclobutane pyrimidine dimers (CPDs) and (6-4) photoproducts (6-4PPs) and the main repair pathways of theses lesions involve photolyases and various excision repair

Boken Öronakupunktur är lättläst och tänkt att användas som lärobok. För yrkesutövare kommer boken förhoppningsvis att användas som referenslitteratur i det dagliga akupunkturarbetet. Den kan också läsas av en bredare läsekrets med ett allmänt intresse för öronakupunktur.

There are water vapour condensation and two-phase flow in plate heat exchangers when they are used as condensers. Water phase change and flow dynamics modelling is an important but complicated task due to large change in water physical/transport properties across the water liquid-vapour interface boundary. In particular, singular-link behaviour in governing equations is present due to the large st