Background: Residential care homes (RCHs) play an important role in end-of-life care, being the most common place of death for elderly people in several European countries. Care pathways such as the Liverpool Care Pathway for the Dying Patient (LCP) are used to improve and ensure quality care at the end of life. There is a lack of scientific evidence supporting the use of care pathways. Design: A

Hypoxia-inducible factors enhance glioma stemness, and glioma stem cells have an amplified hypoxic response despite residing within a perivascular niche. Still, little is known about differential HIF regulation in stem versus bulk glioma cells. We show that the intracellular domain of stem cell marker CD44 (CD44ICD) is released at hypoxia, binds HIF-2α (but not HIF-1α), enhances HIF target gene ac

Underground infrastructure such as buried district heating pipes are difficult to inspect. The methods available to assess the status of the district heating pipes are often both expensive and do not provide enough evidence to determine the condition of the pipelines. This paper discusses how utilities systematically can work with risk assessments and risk classification to plan the maintenance an

Pricing carbon is often considered to be the cornerstone of any climate policy and, at least in economic theory, it is the only policy intervention required to reach an optimal level of mitigation. In practice, various market and behavioural failures, as well as political barriers, necessitate a policy mix that also encompasses policies to induce energy efficiency and stimulate the up-take of rene

With the purpose of explaining professional audit costs in Swedish municipalities, we hypothesised that audit costs are partly driven by various signalling and monitoring incentives in order to manage stakeholder relationships. Our model of the determinants of audit costs was tested on data from Swedish municipalities, thus extending the study of audit costs to political organisations in a Scandin

Alzheimer's disease (AD) is increasingly viewed as a disease of synapses. Loss of synapses correlates better with cognitive decline than amyloid plaques and neurofibrillary tangles, the hallmark neuropathological lesions of AD. Soluble forms of amyloid-β (Aβ) have emerged as mediators of synapse dysfunction. Aβ binds to, accumulates, and aggregates in synapses. However, the anatomical and neurotra

The growth of electrodeposited lithium microstructures on metallic lithium electrodes has prevented their use in rechargeable lithium batteries due to early performance degradation and safety implications. Understanding the evolution of lithium microstructures during battery operation is crucial for the development of an effective and safe rechargeable lithium-metal battery. This study employs bot

Occupancy of cold habitats by evergreen species requires structural modification of photosynthetic organs for stress resistance and longevity. Such modifications have been described at interspecific level, while intraspecific variation has been underexplored. To identify structural and anatomical traits that may be adaptive in cold environments, we studied intraspecific variability of needles of S

Context: Variation in genes that cause maturity-onset diabetes of the young (MODY) has been associated with diabetes incidence and glycemic traits. Objectives: This study aimed to determine whether genetic variation in MODY genes leads to differential responses to insulin-sensitizing interventions. Design and Setting: This was a secondary analysis of a multicenter, randomized clinical trial, the D

Context. Due to their volatile nature, when sulphur and zinc are observed in external galaxies, their determined abundances represent the gas-phase abundances in the interstellar medium. This implies that they can be used as tracers of the chemical enrichment of matter in the Universe at high redshift. Comparable observations in stars are more difficult and, until recently, plagued by small number

Världens befolkning ökar och i takt med det utbredningen av städer och urbana miljöer. Urbaniseringen är en extrem utmaning för många djurarter och antalet arter har minskat i takt med urbaniseringen. Trots detta finns det en hel del arter som tillsynes verkar blomstra i staden, mycket tack vara den rika tillgången till mat. Men så finns det en också baksida, nämligen de olika miljöföreningar som Urbanisation of natural habitats is rapidly intensifying and poses a potential global threat for wildlife. Thus, it is important to explore its impact on wildlife in order to understand the present and future threats and how resilient organisms are to them. Although many species decline in abundance or even disappear once an area is urbanised, some species, populations and/or individuals are able

Presenterar Crusenstolpes erfarenheter av Lund och Lunds universitet med fokus på hans samtidsroman Tvenne äktenskap (1847).

The synthesis and characterization of three ligands and their respective heterobinuclear FeIIIZnII complexes were carried out, with the goal of mimicking the active site of purple acid phosphatases (PAPs). The ligand 2-hydroxy-3-(((2-hydroxy-5-methyl-3-(((2-(pyridin-2-yl)ethyl)(pyridin-2-ylmethyl)amino)methyl)benzyl)(pyridin-2ylmethyl)amino)methyl)-5-methylbenzaldehyde (H2L2) was synthesized and i

In this article five scenarios for fully electric road transport in Sweden are compared, looking at the total system cost for different combinations of battery systems, vehicle equipment and charging solutions, including the use of Electric Road Systems (ERS). The main objective of this work is not to provide accurate price estimations, but to help understanding the main cost drivers of transport

Problems with bottlenecks in district heating networks occur when the pipes have too small dimensions to sufficiently meet customer needs. This may result in insufficient differential pressure in DH areas attached to these pipes. Bottlenecks are especially common in expanding DH networks, as previously sufficient pipe diameters may become too small when more DH consumers are connected to the DH ne

Objective: Phase-change heat transfer enhancement is of critical importance to meet high cooling demands. Method: Recently, surface engineering (surface structuring) has emerged as a promising heat transfer enhancement method, especially with the development of nanotechnology. Surface parameters such as wettability, surface roughness and porosity are modified by surface engineering. Aims: This wor

Objective: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involvement of microRNAs is well established, the contribution of long non-coding RNAs (lncRNAs) in the regulation of β-cell functions and in diabetes development remains poorly understood. The aim of this study was to identify novel islet lncRNAs differently expressed in type 2 diabetes models and to inv