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Vasoactive peptides associate with treatment outcome ofbevacizumab-containing therapy in metastatic colorectal cancer
Textual Fluidity in Early Monasticism : Sayings, Sermons and Stories
Det tidiga klosterväsendet och den antika bildningen. : Slutrapport från ett forskningsprogram
Denna rapport sammanfattar resultaten av forskningsprogrammet ”Det tidiga klosterväsendet och den antika bildningen”, som pågick åren 2009-2015. Rapporten är författad av programmets forskningsledare Samuel Rubenson, men bygger på det omfattande arbete som gjorts av programmets olika forskare: Elin Andersson, Anahit Avagyan, Jesper Blid Kullberg, Karin Kulneff-Eriksson, Britt Dahlman, Bo Holmberg,
Varying scopes for doctoral students’ creativity in four disciplines
Benchmarking of learning architectures for digital predistortion
Indirect and direct learning architectures are the two main parameter identification approaches for digital predistortion systems. While the indirect scheme is less complex, its inherent shortcomings are avoided by the direct learning approach. Trying to answer the question whether this advantage of the direct approach can be exploited in terms of measurable linearization-performance improvement i
High-level system synthesis and optimization of dataflow programs for MPSoCs
The growing complexity of digital signal processing applications make a compelling case the use of high-level design and synthesis methodologies for the implementation on reconfigurable and embedded devices. Past research has shown that raising the level of abstraction of design stages does not necessarily gives penalties in terms of performance or resources. Dataflow programs provide behavioral d
Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function
Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr
RIFM fragrance ingredient safety assessment, isoamyl acetate, CAS Registry Number 123-92-2
RIFM fragrance ingredient safety assessment, isoamyl hexanoate, CAS Registry Number 2198-61-0
Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome
Here we hypothesized that exercise in dihydrotestosterone (DHT) or letrozole (LET)-induced polycystic ovary syndrome mouse models improves impaired insulin and glucose metabolism, adipose tissue morphology, and expression of genes related to adipogenesis, lipid metabolism, Notch pathway and browning in inguinal and mesenteric fat. DHT-exposed mice had increased body weight, increased number of lar
The origin of ambling horses
Horseback riding is the most fundamental use of domestic horses and has had a huge influence on the development of human societies for millennia. Over time, riding techniques and the style of riding improved. Therefore, horses with the ability to perform comfortable gaits (e.g. ambling or pacing), so-called ‘gaited’ horses, have been highly valued by humans, especially for long distance travel. Re
Synthesis of naproxen-imprinted polymer using Pickering emulsion polymerization
For the last decades, molecular imprinting is developing intensively, especially in the case of the application of new imprinting techniques. In this work, for the first time, a Pickering emulsion polymerization was used to synthesize the S-naproxen-imprinted polymer spheres following a noncovalent protocol. To enhance the knowledge about imprinting process using mentioned technique, thorough anal
Optimized long-range corrected density functionals for electronic and optical properties of bare and ligated CdSe quantum dots
The reliable prediction of optical and fundamental gaps of finite size systems using density functional theory requires to account for the potential self-interaction error, which is notorious for degrading the description of charge transfer transitions. One solution is provided by parametrized long-range corrected functionals such as LC-BLYP, which can be tuned such as to describe certain properti
Cambrian trilobite biostratigraphy and its role in developing an integrated history of the Earth system
One of the principal biostratigraphical tools used in the lower Palaeozoic, and especially the Cambrian System, is trilobites. Historically, both polymerids and agnostoids have commonly been included as 'trilobite' groups, although currently the question of whether they comprise a monophyletic group or are polyphyletic is unsettled. Beginning in the late 1800s, the base of the Cambrian System was
The endangered São Tomé Grosbeak Neospiza concolor is the world's largest canary
The São Tomé Grosbeak Neospiza concolor, endemic to the island of São Tomé (Gulf of Guinea), is one of the least known birds in the world. Formerly considered to be an aberrant weaver (Ploceidae), it is currently placed in a monotypic genus within the true finches (Fringillidae). Phylogenetic inference based on mitochondrial and nuclear sequences confidently identifies N. concolor as an Old World
The importance of benthic-pelagic coupling for marine ecosystem functioning in a changing world
Benthic-pelagic coupling is manifested as the exchange of energy, mass, or nutrients between benthic and pelagic habitats. It plays a prominent role in aquatic ecosystems, and it is crucial to functions from nutrient cycling to energy transfer in food webs. Coastal and estuarine ecosystem structure and function are strongly affected by anthropogenic pressures; however, there are large gaps in our
The association between health utility and joint status among people with severe haemophilia A : findings from the KAPPA register
INTRODUCTION: People with severe haemophilia A have reportedly impaired health related quality of life (utility) mainly due to recurrent bleeding, arthropathy and treatment burden.AIM: To estimate utilities and evaluate their potential correlates - most importantly the joint status - among people with severe haemophilia A.METHODS: In this cross-sectional study, eligible participants had severe hae
Don't forget to look down - collaborative approaches to predator conservation
ABSTRACT: Finding effective ways of conserving large carnivores is widely recognised as a priority in conservation. However, there is disagreement about the most effective way to do this, with some favouring top-down 'command and control' approaches and others favouring collaboration. Arguments for coercive top-down approaches have been presented elsewhere; here we present arguments for collaborat
Comparative burden of arthropathy in mild haemophilia : a register-based study in Sweden
INTRODUCTION: Mild haemophilia is a congenital bleeding disorder affecting males. The burden of arthropathy in mild haemophilia has not been comprehensively described.AIM: The aim of this study was to compare the incidence, age at diagnosis and surgery for arthropathy and related hospitalizations between people with mild haemophilia and the general population in Sweden.METHODS: This was a register