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Neural grafting in Parkinson's disease: problems and possibilities
Neural transplantation has emerged as a possible therapy for Parkinson's disease (PD). Clinical studies performed during the 1990s, where dopaminergic neurons derived from the human embryonic brain were transplanted into striatum of patients with PD, provided proof-of-principle that long-lasting therapeutic benefits can be achieved. Subsequent studies, in particular two that followed a double-blin
In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully prevented: data from the methotrexate responders population in the SWEFOT trial
Objective To investigate the 2-year clinical and radiological outcomes of patients with early rheumatoid arthritis (RA; symptom duration
A Miniaturized Marchand Balun in CMOS With Improved Balance for Millimeter-Wave Applications
The analysis and design of a millimeter-wave passive balun on silicon substrate with small size and good balance is presented. The reason for the imbalance of the balun is analyzed and a novel method using two grounded T bars beneath the coupled lines to tune the balance is proposed. The balun was fabricated in a 65 nm CMOS process, by using broadside coupled lines with small separation, the lengt
The PPARGC1A Gly482Ser polymorphism is associated with left ventricular diastolic dysfunction in men
Background: The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are important risk factors for left ventricular diastolic dysfunction. Methods: The PPARGC1A Gly482Ser polymorphism was genotyped in a community-based cohort of 499 men and 533 women, w
Inhibitors in haemophilia A - Prevention, current management and personalised therapy perspectives
Heat Transfer and Flow Characteristics in Rib-/Deflector-Roughened Cooling Channels with Various Configuration Parameters
The present paper deals with a detailed numerical investigation of the turbulent flow inside a stationary rib-/deflector-roughened cooling channel. Various downstream-shaped deflectors including sloping-board deflectors [Cases A1, A2], guide-shaped deflectors [Cases B1, B2], and drop-shaped deflectors [Cases C1, C2] and configuration parameters such as channel aspect ratio (AR=0.5, 1 and 2), and r
Acute pancreatitis - severity classification, complications and outcome
Popular Abstract in Swedish Akut bukspottkörtelinflammation är en sjukdom som drabbar ungefär 35 per 100 000 invånare i Sverige årligen. Förloppet innebär i flertalet fall ett komplikationsfritt tillfrisknande. Cirka 20% drabbas dock av en allvarlig form som kräver stora sjukvårdsresurser och innebär avsevärd sjuklighet, inkluderande risk för vävnadsdöd i bukspottkörteln, lokala och spridda infektAcute pancreatitis, with an annual incidence of approximately 35 per 100 000 inhabitants in Sweden, is in most cases mild and self-limiting. Severe acute pancreatitis, affecting 10-15% of the cases is, however, associated with severe complications and even death. The optimal management of acute pancreatitis includes accurate early prediction of the disease severity. The aims of this thesis were to
Conceptual change and development on multiple time scales: From incremental evolution to origins
In the context of the relationship between signs and concepts, this paper tackles head on some of the ongoing controversies over conceptual development and change – including the claim by some that concepts are not open to revision at all – taking the position that concepts pull apart from language and that concepts can be discussed on at least four levels: that of individual agent, community, soc
DNA methylation and differential gene regulation in photoreceptor cell death.
Retinitis pigmentosa (RP) defines a group of inherited degenerative retinal diseases causing progressive loss of photoreceptors. To this day, RP is still untreatable and rational treatment development will require a thorough understanding of the underlying cell death mechanisms. Methylation of the DNA base cytosine by DNA methyltransferases (DNMTs) is an important epigenetic factor regulating gene
Predictive factors of sustained return to work for persons with musculoskeletal disorders who participated in rehabilitation
Musculoskeletal disorders (MSD) account for the majority of total morbidity cases in the working-age Swedish population. These disorders are thought to be the reason given for one-third of total certified sick leave requests. In addition to the high cost to society, MSD involve both physical and emotional suffering, pain and financial and social problems for the injured persons. The aim of this st
Bohuslänsk identitetsutveckling efter Roskildefreden
In this article I discuss the Nordic province of Bohuslan in the decade after it became 'Swedish' in 1658, at the stage I describe as the province's 'transitional period'. The aim of the study is to show how the traditional understanding of what happens when national borders are redrawn needs to be understood in the light of the nature of the early modern state. Records from the district court of
Online Myoelectric Control of a Dexterous Hand Prosthesis by Transradial Amputees
A real-time pattern recognition algorithm based on k-nearest neighbors and lazy learning was used to classify, voluntary electromyography (EMG) signals and to simultaneously control movements of a dexterous artificial hand. EMG signals were superficially recorded by eight pairs of electrodes from the stumps of five transradial amputees and forearms of five able-bodied participants and used online
Redistribution of moisture and ions in cement based materials
Popular Abstract in Swedish Nygjuten betong innehåller överskottsfukt som avges till omgivningen under uttorkningen. Om uttorkningen får fortsätta i en konstant luftfuktighet antar betongen så småningom samma fuktighet. Eftersom betong är ett tätt material tar det lång tid, ofta flera år, innan så har skett. Tills detta har inträffat sker en fukttransport från de inre delarna ut till ytan. En delThere were two principal objectives for this thesis. The first was to develop a methodology and evaluation model of moisture redistribution in order to make the future relative humidity in a screeded concrete slab predictable. The second objective was to develop a method to determine the critical humidity for ion transport in concrete. Residual moisture in screeded concrete slabs may be redistrib
Tillbaka till framtiden? Robocop och Detroit som dystopi
Jämförelse av filmerna Robocop från 1987 och 2014 och på vilka sätt som respektive samtid speglas i dem.
Inflytande och kundval
Migration Patterns in Duhok Governorate, Iraq, 2000-2010
Migration is commonly associated with large scale movements of people, from one country to another, both in terms of refugee displacement and voluntary migration. The internal movement within countries is however less studied despite the fact that this is an important indicator for imbalance and also crucial for planning the future for the country. In Iraq, a major reason for migration has been se
Unexpected complexity of the Aquaporin gene family in the moss Physcomitrella patens
Background: Aquaporins, also called major intrinsic proteins (MIPs), constitute an ancient superfamily of channel proteins that facilitate the transport of water and small solutes across cell membranes. MIPs are found in almost all living organisms and are particularly abundant in plants where they form a divergent group of proteins able to transport a wide selection of substrates. Results: Analys
The new songs of praise: Text, music and performance from a Swedish perspective
In our contemporary age, the name praise song has got a special meaning, roughly defined as: a song consisting of a rather short text that is sung over and over again, set to music in some contemporary popular style, directed by a worship leader, and accompanied by a team with instruments that may be unusual in church, as el-guitars and drums. The phenomenon is described and critically evaluated.
Ship-Generated Waves and Induced Turbidity in the Gota alv River in Sweden
Ship-generated waves were investigated in the Gota alv river, which is a major waterway on the Swedish west coast between the sea and Lake Vanern. Ships with a typical size of 85x15x5 m (lengthxwidthxdraft) travel at speeds between 5 and 10 knots, generating waves that cause sediment transport and erosion along the river bed and banks. Field measurements of the wave properties and turbidity were c