Over the last decade, a great variety of visionary ideas and beliefs have been brought forward, regarding the potentials of using computer games as a tool for learning and mediation in educational settings. This thesis aims at contributing to research in this field, by empirically exploring what happens when students play and reflect on their computer game play in science education. Three empirica

On the basis of a T = 1 icosahedral capsid model, the capsomer-polyion co-assembly process has been investigated by molecular dynamics simulations using capsomers with different net charge and charge distribution as well as linear, branched, and hyper-branched polyions. The assembly process was characterized in terms of the time-dependent cluster size probabilities, averaged cluster size, encapsul

Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incide

Conceptually, the Satisfaction with Life Scale (SWLS; Diener et al. in J Pers Assess 49(1):71–75, 1985) emphasizes evaluations comparing actual and expected life circumstances. Contrastingly we developed the Harmony in Life Scale (HILS) emphasiz-ing psychological balance and flexibility in life. Study 1 (476 participants) developed the HILS. In Study 2 participants (N = 787, T1; N = 545, T2) answe

Core-shell-structured nanoalloy particles with an Al-dominated interior covered by few Yb monolayers have been fabricated using a vapor-aggregation method involving magnetron sputtering. The radially segregated structure of the Yb-Al nanoparticles has been disclosed by "on-the-fly" photoelectron spectroscopy monitoring of the nanoparticle beam in Yb 4f and Al 2p electron binding energy regions. Bo

Saving time to intervention is crucial in patients with symptomatic carotid artery stenosis (SCAS). We introduced a fast-track protocol (FTP). Time frames from the onset of symptoms to intervention before and after the introduction of an FTP were analyzed. SCAS patients (403 patients/405 procedures) were evaluated according to whether surgery was performed before (group 1) or after (group 2) the i

Abstract in UndeterminedUsing longitudinal data this work analyses historical fertility between 1834 and 1914 in an Alpine village situated in north-east Italy, characterised by scarce resources and by an economy which passed from being traditional and based on closed subsistence to becoming open and integrated. During the initial period studied, this territory can be described as a natural fertil

Wnt5a is a non-canonical Wnt protein that is expressed at elevated levels in inflammatory conditions. Its role in inflammation remains unclear, although it is known that Wnt5a is expressed at a higher level in monocyte-derived myeloid dendritic cells (Mo-mDCs) than in monocytes and macrophages. The function of Wnt5a in dendritic cells (DCs) remains relatively unexplored. Here, we found that under

Molecular simulations of strongly coupled dipolar systems of varying size have been carried out, using particles confined inside a dielectric cavity and an image charge approach to treat the dielectric response from the surroundings. A simple method using penalty functions was employed to create an isotropic and homogeneous distribution of particles inside the cavity. The dielectric response of th

Using quantum dot fluorescence imaging, we investigated the interference of surface plasmon beams in branched silver nanowire structures. Depending on the phases and polarizations of the incident light, interferences of plasmon beams modulate the plasmon propagation in the branched structures and the output light intensity in the distal ends. The interference visibility is strongly dependent on th

Cross-sectional studies suggest that premature birth and low birth weight may both be associated with low peak bone mass. We followed bone traits in preterm individuals and controls for 27 years and examined the effects of birth weight relative to gestational age [stratified as small for gestational age (SGA) or appropriate for gestational (AGA)] on adult bone mineral density (BMD). We measured di

When sexually selected traits diverge because of different local selective environments, premating isolation might arise as a correlated response. However, sexually selected traits might also diverge by stochastic forces. Here, we show that odour-based mate preferences and scent composition have diverged between islet- and mainland populations of Skyros wall lizard, Podarcis gaigeae. We quantified

Background. Infections are the most commonly reported health problems in children. Younger age and day care outside the home are two factors of importance for infectious morbidity. The influence of siblings on infectious symptoms is not clear. Objectives. To compare families with one child and families with more than one child in terms of reported infectious symptoms, physician consultations and a

The perfusion-/diffusion-weighted imaging (PWI/DWI) mismatch and the diffusion/fluid attenuated inversion recovery (DWI/FLAIR) mismatch are magnetic resonance imaging (MRI) markers of evolving brain ischemia. We examined whether the DWI/FLAIR mismatch was independently associated with the PWI/DWI mismatch. Furthermore, we determined whether the presence of the DWI/FLAIR mismatch in patients with t

In animals, exposure to certain phthalates negatively affects the male reproductive function. Human results are conflicting and mostly based on subfertile males, in whom the association between exposure and reproductive function may differ from the general population.