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A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1
ETV6-RUNX1 is associated with childhood acute B-lymphoblastic leukemia (cALL) functioning as a first-hit mutation that initiates a clinically silent pre-leukemia in utero. Because lineage commitment hierarchies differ between embryo and adult, and the impact of oncogenes is cell-context dependent, we hypothesized that the childhood affiliation of ETV6-RUNX1 cALL reflects its origins in a progenito
A mechanistic model (BCC-PSSICO) to predict changes in the hydraulic properties for bio-amended variably saturated soils
The accumulation of biofilms in porous media is likely to influence the overall hydraulic properties and, consequently, a sound understanding of the process is required for the proper design and management of many technological applications. In order to bring some light into this phenomenon we present a mechanistic model to study the variably saturated hydraulic properties of bio-amended soils. Sp
Smoking is the most significant modifiable lung cancer risk factor in systemic lupus erythematosus
Objective. To assess lung cancer risk in systemic lupus erythematosus (SLE), relative to demographics, drug exposures, smoking, and disease activity. Methods.We analyzed data from 14 SLE cohorts. We calculated adjusted HR estimates for lung cancer in SLE, relative to demographics, smoking, time-dependent medication exposures, and cumulative disease activity [mean adjusted SLE Disease Activity Inde
RIFM fragrance ingredient safety assessment, 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-4-en-2-ol, CAS Registry Number 67801-20-1
Mobilshopping : Nya shoppingpraktiker växer fram
A review of paleo El Niño-Southern Oscillation
The Earth has seen El Niño-Southern Oscillation (ENSO)-the leading mode of interannual climate variability-for at least millennia and likely over millions of years. This paper reviews previous studies from perspectives of both paleoclimate proxy data (from traditional sediment records to the latest high-resolution oxygen isotope records) and model simulations (including earlier intermediate models
Impact of androgen action on reproduction and cardiovascular disease in male cancer survivors
Ecological and soil hydraulic implications of microbial responses to stress - A modeling analysis
Spatial Encoding of Translational Optic Flow in Planar Scenes by Elementary Motion Detector Arrays
Elementary Motion Detectors (EMD) are well-established models of visual motion estimation in insects. The response of EMDs are tuned to specific temporal and spatial frequencies of the input stimuli, which matches the behavioural response of insects to wide-field image rotation, called the optomotor response. However, other behaviours, such as speed and position control, cannot be fully accounted
Antenatal corticosteroids : a retrospective cohort study on timing, indications and neonatal outcome
Introduction: An antenatal corticosteroid (ACS) delivery interval of 24 h to seven days is commonly referred to as optimal timing. We aimed to investigate whether the ACS delivery interval was associated with the obstetric indication for treatment and with neonatal complications. Material and methods: The study was a retrospective chart review of clinical data from preterm neonates delivered at th
Extreme prematurity, treated retinopathy, bronchopulmonary dysplasia and cerebral palsy are significant risk factors for ophthalmological abnormalities at 6.5 years of age
Aim: This study evaluated the contributions of various prenatal and postnatal predictive factors to a documented high prevalence of ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm. Methods: We carried out a prospective population-based study of all children born in Sweden at a gestational age of 22 + 0 to 26 + 6 weeks based on the Extremely Preterm Infants
Sufficiency, change, and flexibility : Critically examining the energy consumption profiles of solar PV prosumers in Sweden
The number of consumers producing electricity at home, i.e., “prosumers”, is rapidly increasing in many European countries. This article analyses the electricity consumption and energy-saving behaviours of households that own photovoltaic (PV) systems in Sweden. Earlier studies of how home production of electricity affects consumption patterns are few and their results are mixed. We interviewed pr
Large uncertainty in carbon uptake potential of land-based climate-change mitigation efforts
Most climate mitigation scenarios involve negative emissions, especially those that aim to limit global temperature increase to 2°C or less. However, the carbon uptake potential in land-based climate change mitigation efforts is highly uncertain. Here, we address this uncertainty by using two land-based mitigation scenarios from two land-use models (IMAGE and MAgPIE) as input to four dynamic globa
Light-dependent magnetoreception in zebra finches : - from behaviour to receptor
Fåglarnas förmåga att flyga över extremt långa sträckor utan att hamna vilse harförvånat människor i århundraden. Det är känt att djur kan använda solens ellerstjärnornas läge, landmärken och jordens magnetfält som informationskälla förorientering, det vill säga de kan använda källan för att få kompassinformation.Eftersom magnetfältet är närvarande överallt på planeten kan magnetiskkompassinformatIt is well known that animals can use a wide variety of information sources to help them orient and navigate asthey move over short or long distances. Birds can rely on information from the sun, the skylight polarizationpattern, the stars, landmarks and the Earth’s magnetic field for orientation and navigation. However, despite thebehavioural evidence supporting the use of the magnetic field as an
Visual Analysis of Sentiment and Stance in Social Media Texts
Despite the growing interest for visualization of sentiments and emotions in textual data, the task of detecting and visualizing various stances is not addressed well by the existing approaches. The challenges associated with this task include development of the underlying computational methods and visualization of the corresponding multi-label stance classification results. In this poster abstrac
Swedish Naturalists in South Africa 1771–1951
Gapmending strategies: Impact on social workers occupational practice
Gapmending strategies: Impact on social workers occupational practiceGap-mending is a concept, which is used to create reflection and analysis of gaps that exist between different actors in social work. The gaps can be explicit or implicit distinctions between individuals, groups or organisations in Social Work. The gap-mending concept is not a specific model or method, but should be seen as an an
Evaluation of changes in Bone Scan Index at different acquisition time-points in bone scintigraphy
Bone Scan Index (BSI) is a validated imaging biomarker to objectively assess tumour burden in bone in patients with prostate cancer, and can be used to monitor treatment response. It is not known if BSI is significantly altered when images are acquired at a time difference of 1 h. The aim of this study was to investigate if automatic calculation of BSI is affected when images are acquired 1 hour a
Tension fields between discourses: Sweden's Art and Music Schools as constituted within and through their leaders' discursive practices
Art and Music Schools (kulturskolor) are present in about 97% of Sweden’s municipalities, reaching over 400.000 children and adolescents both in activities outside of and in collaboration with compulsory schools. A national policy has never been established for Art and Music Schools, possibly owing to the fact that they are not considered part of the Swedish education system, but instead stem from