Abstract Treatment of chronic inflammatory arthritis has undergone major changes over the past years following introduction of targeted biological therapies. Tumour necrosis factor (TNF) blocking therapy has been the most important biological treatment of chronic arthritis to date. The overall objective of this thesis was to develop a new assessment method of efficacy of biological therapy in clin

Foreword to the publication.

The 24th of April 2015 will mark the centennial commemoration of the Armenian genocide and is expected to be a worldwide ceremony. Hundred years will have passed since the start of the state orchestrated massacres and deportations in 1915 which emptied the majority of historical Armenia from its native population. A century has passed, but ironically, the Armenian genocide seems to become more top

Because of its existential character, organ transplantation is strongly connected to a person's view of life. This article describes how participants in a focus group use religious elements in decision-making on transplantation medicine in four European countries. Further these findings are related to two influential theologians: James Gustafson and Paul Ramsey, and their thinking on the role of r

In this paper a modified two-dimensional Luikov model for evaluating the non-isothermal moisture migration in porous building materials was proposed. The coupled heat and moisture transfer problem was modeled. Vapor content and temperature were chosen as the principal driving potentials. The coupled equations were solved by a numerical method, which consists of a finite difference technique with a

Enumeration of circulating tumor cells (CTCs) obtained from minimally invasive blood samples has been well established as a valuable monitoring tool in metastatic and early breast cancer, as well as in several other cancer types. The gold standard technology for detecting CTCs in blood against a backdrop of millions of leukocytes is the FDA-approved CellSearch system (Janssen Diagnostics), which r

The Mobile Service Support system (MSS), which Ericsson AB develops, handles the setup of new subscribers and services into a mobile network. Experience from deployed systems show that traffic monitoring and control of the system will be crucial for handling overload situations that may occur at sudden traffic surges. In this paper we identify and explore some important control challenges for this

Disperse dyes are the most common allergens among textile dyes. It is not known whether the purified dyes, impurities in the commercial dyes, or metabolites are the actual sensitisers. Moreover, it is not known whether those disperse dyes that are now present in test series are actually used in textile dyeing today. The aim of this thesis was A) to evaluate the significance of the impurities foun

Popular Abstract in Swedish Allt fler människor drabbas av cancer, som idag är den ledande dödsorsaken globalt. De vanligaste cancerformerna i världen är lungcancer, bröstcancer och tjocktarmscancer och det är störst risk att dö i lungcancer, levercancer och magcancer. Även i Sverige ökar antalet cancerfall, till stor del på grund av att vi lever allt längre och cancer är idag en av våra stora folCancer incidence is increasing and it is the number one cause of death worldwide. Cancer is a highly heterogeneous disease and there is a great need for new early diagnostic, prognostic and treatment predictive biomarkers in order to improve patient outcomes. The RNA-binding motif protein 3, RBM3, is an emerging candidate biomarker of favourable prognosis and treatment response in several types of

The objective of this study has been to develop technologies that can reduce the content of active pharmaceutical ingredients (APIs) and bacteria from hospital wastewater. The results from the laboratory-and pilot-scale testings showed that efficient removal of the vast majority of APIs could be achieved by a membrane bioreactor (MBR) followed by ozone, ozone + hydrogen peroxide or powdered activa

Brevican is known to be an abundant extracellular matrix component in the adult brain and a structural constituent of perineuronal nets. We herein show that brevican, tenascin-R (TN-R) and phosphacan are present at the nodes of Ranvier on myelinated axons with a particularly large diameter in the central nervous system. A brevican deficiency resulted in a reorganization of the nodal matrices, whic

Background: Prior studies have identified some risk factors for stress fracture in athletes and military recruits. Objective: To determine whether historical factors, physical measures, biochemical variables of skeletal metabolism, genetic factors, bone density (BMD) and bone size could predict risk of stress fracture over 4 years in physically fit cadets at the US Military Academy (USMA). Methods

Despite various criticisms, Ian Barbour's fourfold classification of the possible relationships between religion and science remains influential. I compare Barbour's taxonomy with the theories of four authors who, in the last four decades, have addressed the relationship between science and religion from a Muslim perspective. The aim of my analysis is twofold. First, I offer a comparative perspect

Isla de los Estados (54A degrees 45'S, 63A degrees 10'aEuro"64A degrees 46'W) lies east of the main island of Tierra del Fuego and is the southeastern-most point in Argentina. Because of its geographic position near the latitudes of the Southern Hemisphere Westerlies and the strong influence of the Antarctic Circumpolar Current (ACC), the area is suitable for paleoecological and paleoclimate resea

Although no common genetic defect has been described in chronic lymphocytic leukemia (CLL), recurrent genomic aberrations (i.e. deletions of chromosome 11q, 13q, 17p and trisomy 12) are important for prognostication. Deletion of 13q as single aberration is associated with the best prognosis, whereas del(11q) and del(17p) predict a poor outcome. Recent development of high-resolution genomic techniq

Many developing countries would like to increase employment in the formal sectors. One way to accomplish this goal may be to encourage the entrance of foreign firms. We examine employment growth in Indonesian plants taken over by foreign owners from domestic ones. We also examine the effect of FDI during different trade regimes and the timing of employment effects following an acquisition. For pla

Background. Male breast cancer (MBC) is an uncommon disease and there is limited information on the prognostic impact of routinely used clinicopathological parameters. Material and methods. In a retrospective setting, we reviewed 197 MBC patients with accessible paraffin-embedded tumor tissue and clinicopathological data. Immunohistochemical (IHC) stainings were performed on tissue microarrays and

The research network "Basic Concepts for Convection Parameterization in Weather Forecast and Climate Models" was organized with European funding (COST Action E50905) for the period of 2010-2014. Its extensive brainstorming suggests how the subgrid-scale parameterization problem in atmospheric modeling, especially for convection, can be examined and developed from the point of view of a robust theo

Nanowires grown with the vapor-liquid-solid method commonly exhibit polytypism, showing both zincblende and wurtzite crystal structure. We have grown p-type InP nanowires using DEZn as a dopant precursor and studied the wetting of the seed particle and the nanowire crystal structure. The nanowires grown with high DEZn molar fractions exhibit deformed seed particles after growth. We observe 20% sma