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Several computational methods have been developed for predicting the effects of rapidly expanding variation data. Comparison of the performance of tools has been very difficult as the methods have been trained and tested with different datasets. Until now, unbiased and representative benchmark datasets have been missing. We have developed a benchmark database suite, VariBench, to overcome this pro
At the waste handling company NSR, Helsingborg, Sweden, the food waste fraction of source separated municipal solid waste is pretreated to obtain a liquid fraction, which is used for biogas production, and a dry fraction, which is at present incinerated. This pretreatment and separation is performed to remove impurities, however also some of the organic material is removed. The possibility of real
Functional analysis of quantitative expression data is becoming common practice within the proteomics and transcriptomics fields; however, a gold standard for this type of analysis has yet not emerged. To grasp the systemic changes in biological systems, efficient and robust methods are needed for data analysis following expression regulation experiments. We discuss several conceptual and practica
OBJECTIVE: Research concerning spinal mobility in axial spondyloarthritis (axSpA) has focused on ankylosing spondylitis (AS), and data on the clinical diagnosis of undifferentiated spondyloarthritis (USpA) are limited. The objective was to study differences in spinal mobility between axSpA subgroups AS and USpA, including gender differences. METHODS: A total of 183 patients with axSpA from a rhe
BACKGROUND: Familial breast cancers are known to be of early onset. This article provides differences in the age of onset of breast cancer and death by breast cancer between women with and without a family history. METHODS: The Swedish Family-Cancer Database was used to estimate the cumulative risk of breast cancer and death by breast cancer according to family history with a stratified Cox model.
As our understanding of genetics has increased, so has the number of genetic tests that have entered clinical practice. Given the need of many European health care systems to contain costs, the question of how to prioritise genetic tests fairly has become an emerging concern. This study uses a discrete-choice experiment to assess the value judgements of clinical geneticists, patient representative
In order to gain further insight into (i) the use of conditioned quantities for characterizing turbulence within a premixed flame brush and (ii) the influence of front propagation on turbulent scalar transport, a 3D Direct Numerical Simulation (DNS) study of an infinitely thin front that self-propagates in statistically stationary, homogeneous, isotropic, forced turbulence was performed by numeric
In this paper, we generalize Szegőʼs theorem for orthogonal polynomials on the real line to infinite gap sets of Parreau–Widom type. This notion includes Cantor sets of positive measure. The Szegő condition involves the equilibrium measure which in turn is absolutely continuous. Our approach builds on a canonical factorization of the M-function and the covering space formalism of Sodin–Yuditskii.
We describe the career of John Birks as a pioneering scientist who has, over a career spanning five decades, transformed palaeoecology from a largely descriptive to a rigorous quantitative science relevant to contemporary questions in ecology and environmental change. We review his influence on students and colleagues not only at Cambridge and Bergen Universities, his places of primary employment,
The very bright red star HV2112 in the Small Magellanic Cloud could be a massive Thorne-A >> ytkow object (TA >> O), a supergiant-like star with a degenerate neutron core. With a luminosity of over 10(5) L-aS (TM), it could also be a super asymptotic giant branch (SAGB) star, a star with an oxygen/neon core supported by electron degeneracy and undergoing thermal pulses with third dredge up. Both T
Nanocomposite membranes based on poly-(ethylene-co-vinyl acetate) copolymer (18% vinyl acetate content)and two different organomodified clays have been prepared by mechanical mixing using two roll mill method. The morphology of the nanocomposites was investigated using small angle X-ray scattering, scanning electron microscopy, and transmission electron microscopy. The mechanical and thermal studi
A double conformationally restricted kinetically labile supramolecular catalytic system, the third generation, was designed and synthesized. We investigated the substrate selectivity of this system by performing competitive pairwise epoxidations of pyridyl-and phenyl-appended olefins. We compared the obtained substrate selectivities to previous less preorganized generations of this system. Five di
Oxygen binding and cleavage are important for both molecular recognition and catalysis. Mn-based porphyrins in particular are used as catalysts for the epoxidation of alkenes, and in this study the homolytic cleavage of O-2 by a surface-supported monolayer of Mn porphyrins on Ag(111) is demonstrated by scanning tunneling microscopy, X-ray absorption, and X-ray photoemission. As deposited, {5,10,15
Numerous reports over the years have described neuroinflammatory events and vascular changes in neurodegenerative diseases such as Alzheimers disease (AD) and dementia with Lewy bodies (DLB). Interestingly, recent reports from other research areas suggest that the inflammatory and vascular processes are influenced by gender. These findings are intriguing from the perspective that women show a high
The onset of Earth's present icehouse climate in the Late Eocene coincides with astronomical events of enigmatic causation. At similar to 36 Ma ago the 90-100 km large Popigai and Chesapeake Bay impact structures formed within similar to 10-20 ka. Enrichments of He-3 in coeval sediments also indicate high fluxes of interplanetary dust to Earth for 2 Ma. Additionally, several medium-sized impact st
Primary headaches such as migraine are postulated to involve the activation of sensory trigeminal pain neurons that innervate intracranial blood vessels and the dura mater. It is suggested that local activation of these sensory nerves may involve dural mast cells as one factor in local inflammation, causing sensitization of meningeal nociceptors. Immunofluorescence was used to study the detailed d
There is a need for an alternative method to conventional pumping tests that is logistically easier and faster to use and which can be handled by only one person. The well known slug test fulfils those requirements if the equipment is properly designed. The applicability of small-diameter slug-test equipment using pneumatic initiation in large-diameter wells, up to 12aEuro(3) (0.3 m), is discussed
Serotonin 5-HT1A receptor agonists reduce l-DOPA-induced dyskinesia (LID) in animal models of Parkinson's disease (PD). Here, we compared the effects of novel 5-HT1A receptor 'biased agonists' on LID in hemiparkinsonian rats. F13714 preferentially activates pre-synaptic 5-HT1A autoreceptors. F15599 preferentially activates cortical postsynaptic 5-HT1A heteroreceptors. The partial agonist, tandospi
Among the Gram-positive anaerobic bacteria associated with clinical infections, the Gram-positive anaerobic cocci (GPAC) are the most prominent and account for approximately 25-30% of all isolated anaerobic bacteria from clinical specimens. Still, routine culture and identification of these slowly growing anaerobes to the species level has been limited in the diagnostic laboratory, mainly due to t
Objective. To explore experienced general practitioner (GP) tutor perceptions of a skilled GP tutor of medical students. Design. Interview study based on focus groups. Setting. Twenty GPs experienced in tutoring medical students at primary health care centres in two Swedish regions were interviewed. Method. Four focus-group interviews were analysed using qualitative content analysis. Subjects. Twe
