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The conversion of the β-amyloid (Aβ) peptide into pathogenic aggregates is linked to the onset and progression of Alzheimer's disease. Although this observation has prompted an extensive search for therapeutic agents to modulate the concentration of Aβ or inhibit its aggregation, all clinical trials with these objectives have so far failed, at least in part because of a lack of understanding of th

Abstract is not available

This paper gives a short review of the most requirements for the concrete to be used for the 3.510 m long immersed tunnel from Amager (outside Copenhagen Airport) to an artificial double island south of Saltholm (in the middle of Oresund). The basis for the requirements is shortly commented.

We present a new duplex scheme, called Zipper, for discrete multitone (DMT)-based very high bit-rate digital subscriber line (VDSL) systems on copper wires. This scheme divides the available bandwidth by assigning different subcarriers for the upstream and downstream directions. It has high flexibility to divide the capacity between the up and downstream, as well as good coexistence possibilities

Popular Abstract in Swedish Läkekonst är uttryck för våra försök att bemöta och betvinga det svåra som livet ställer oss inför i form av fysiskt och mentalt lidande. Läkekonst formas dock inte bara av våra kunskaper och tekniska framsteg, utan även av grundläggande kulturella värderingar och traditioner. Genom att studera medeltidens och renässansens läkekonst kan vi därför komma en liten bit närmThis doctoral thesis examines the arts of healing in the area of present-day Sweden dur¬ing the Middle Ages and the Renaissance (ca. 1100–1600 AD). It focuses on secular arts of healing for the body, rather than magical and religious healing or the cure of the soul. It is done by studying material culture in the form of archaeological finds from Southern Sweden and contemporary written sources fro

For decades non-Nordic countries have consistently reported high rates of somatic health problems among children placed in care by the authorities. This study examined the unmet health and dental care needs of Swedish children in foster and residential care.

A look at the work and life of British film critic Robin Wood. Includes personal reminiscences of the author's meetings with Wood as well as working on his criticism.

The np P Rydberg sequence of neutral Ytterbium is strongly perturbed. These perturbations were monitored by measuring the g(J) factors and lifetimes of 19 states, including both singlets and triplets as well as states from the perturbing configurations. A pulsed laser setup was used. The g(J) factors were obtained from a Zeeman quantum-beat experiment and the lifetimes by direct observation of the

BACKGROUND: Immunoglobulin A nephritis (IgAN) is the most common primary glomerulonephritis worldwide. It is caused by accumulation of IgA1-containing immune complexes in the kidney resulting in renal failure, which is thought to be due to altered glycosylation of IgA with a decrease of 2-3-sialylated galactosides (NeuAcα2-3Gal). PURPOSE: The purpose of this study was to analyze whether altered gl

ABSTRACT: BACKGROUND: Negative pressure wound therapy (NPWT) is believed to initiate granulation tissue formation via macro-deformation of the wound edge. However, only few studies have been performed to evaluate this hypothesis. The present study was performed to investigate the effects of NPWT on wound contraction and wound edge tissue deformation. METHODS: Six pigs underwent median sternotomy f

With an ever increasing need for assessment of neurophysiological activity in connection with injury and basic research, the demand for an efficient and reliable data acquisition system rises. Brain-machine interfaces is one class of such systems that targets the central nervous system. A necessary step in the development of a brain-machine interface is to design and implement a reliable and effic

Deletion of the tumor suppressor gene p53 has been shown to improve the outcome in experimental models of focal cerebral ischemia and kainate-induced seizures. To evaluate the potential role of p53 in traumatic brain injury, genetically modified mice lacking a functional p53 gene (p53(-/-), n = 9) and their wild-type littermates (p53(+/+), n = 9) were anesthetized and subjected to controlled corti