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Cancer of unknown primary (CUP) is a fatal disease diagnosed through metastases. It shows intriguing familial clustering with certain defined primary cancers. Here we examine whether metastatic location in CUP patients is related to primary non-CUP cancers in relatives based on the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for CUP patients defined by metastatic

A good-performance high-frequency Phase Locked Loop using a ring oscillator is described. A Voltag e Controlled Oscillator with automatic calibration of frequency fluctuated by proce ss and tempe rature variations is propo sed. The VCO adopts new multiple-pass loop to improve frequency with unchangeable stages (phases). The circuit is implemented with TSMC O. I8um standard CMOS technology and powe

Tourism is today the biggest industry in the world, and tour operators are a central link in the tourism supply chain. As a consequence of their key position, tour operators have the potential to influence both the primary producers of tourist services and the tourists. Increased awareness of the media and general public will create pressures on the tour operators - first to work towards incorpora

A critical review of a report by Finn Ole Sonne Nielsens, "Middelalderens Bornholm" (Medieval Bornholm, Rønne 1998) concerning Bornholm during the period c. 1050-1576.

Fms-like tyrosine kinase-3 (FLT3) is a growth factor receptor normally expressed on hematopoietic progenitor cells. Approximately one third of all patients with AML carry an activating mutation in FLT3 that drives proliferation and survival of the leukemic cells. The most common activating mutation is the so-called internal tandem duplication (ITD), which involves an in-frame duplication of a segm

Background. To validate a test for independent assessment of insulin secretion and insulin sensitivity during the same occasion for metabolic studies in clinical practice, i.e. combined glucagon-stimulated C-peptide test and insulin tolerance test (GITT). Subjects and methods. We measured C-peptide response to 0.5 mg of intravenous glucagon followed 30 min later by administration of 0.05 U kg(-1)

Swedish archaeologists have been working in Pompeii since 2000. Our fieldwork has consisted mainly of the study of standing walls and cleared floor levels in a city block unearthed in the 19th century and of the production of a comprehensive documentation, presented in an open access publication: www.pompejiprojektet.se/insula.php. The perspective of the present paper is the insula as a whole. Its

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To cite this article: Stalder J-F, Barbarot S, Wollenberg A, Holm EA, De Raeve L, Seidenari S, Oranje A, Deleuran M, Cambazard F, Svensson A, Simon D, Benfeldt E, Reunala T, Mazereeuv J, Boralevi F, Kunz B, Misery L, Mortz CG, Darsow U, Gelmetti C, Diepgen T, Ring J, Moehrenschlager M, Gieler U, Taïeb A, for the PO-SCORAD Investigators Group. Patient-Oriented SCORAD (PO-SCORAD): a new self-assessm