PURPOSE: Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define pre-clinical autoimmune thyroid disease (AITD) which can progress to either clinical hypo- or hyperthyroidism. We determined the age at seroconversion in children genetically at risk for type 1 diabetes.METHODS: TPOAb and TgAb seropositivity were determined in 5066 healthy children with HLA DR3 or DR4 containing

On the tensions faced by a social venture due to its rapid growth

In conventional cell lysate protocols, cell debris is typically discarded to obtain a cleaner lysate. However, this approach has limitations, as it may overlook vital cellular components. By discarding cell debris, researchers may inadvertently exclude crucial elements. Retaining all cellular components offers several advantages for studying molecular biology within various cellular compartments. In conventional cell lysate protocols, cell debris is typically discarded to obtain a cleaner lysate. However, this approach has limitations, as it may overlook vital cellular components. By discarding cell debris, researchers may inadvertently exclude crucial elements. Retaining all cellular components offers several advantages for studying molecular biology within various cellular compartments.

Objectives To compile a battery of test including various aspects of physical fitness that could be used on the field and to assess whether any of these tests are associated with future traumatic knee injuries in youth female team sports athletes. Design Prospective cohort. Setting Sport setting. Participants Female athletes (n = 117, age 15–19 years), from Swedish sport high schools, active in so

With the emergence of autonomous vehicles comes requirements on adequate and rigorous testing techniques, particularly as systems continuously adapt to changing environments. Scenario-based, simulated testing is one approach that has received attention, where deriving relevant scenarios from various sources is still a challenge. We therefore explore creating executable test scenarios from textual

BACKGROUND: Gout is an inflammatory arthritis manifesting as acute episodes of severe joint pain and swelling, which can progress to chronic tophaceous or chronic erosive gout, or both. Here, we present the most up-to-date global, regional, and national estimates for prevalence and years lived with disability (YLDs) due to gout by sex, age, and location from the Global Burden of Diseases, Injuries

Spark-ignition (SI) aviation piston engines are widely used on light helicopters and unmanned aerial vehicles (UAVs) because of the high-power density and ultra-high cost performance. Kerosene with high flash point is expected to improve safety of aforementioned aircrafts by replacing gasoline. However, in spark-ignition mode, kerosene is difficult to mix and is easy to knock. Short-chain alcohols

This paper presents an experimental study on the combustion stability characteristics and flame/flow dynamics in a multi-nozzle, lean premixed prevaporized (LPP), swirl-stabilized gas turbine model combustor with different swirler configurations in the presence of self-excited combustion instability. The flame structure was characterized using high-speed OH⁎ chemiluminescence imaging and the flow

Effects of axial spark location on the transient flame and flow field dynamics during successful ignition events in a kerosene-fueled gas turbine model combustor were investigated using high-speed flame OH* chemiluminescence (CL) imaging, direct photography, and planar particle image velocimetry (PIV) techniques. The combustor was operated with single nozzle and lean premixed pre-vaporized kerosen

The human ability to maintain upright stance in the presence of external disturbances such as gravity or body-support surface motion has intrigued researchers over the last century.

The effects of transdermally administered scopolamine (TTS-scopolamine, release rate 5 g/h) and dimenhydrinate (100 pmg) were examined on caloriC., angular acceleration induced and optokinetic nystagmus in 16 volunteers in a randomized doubleblind study. All drugs induced a statistically significant decrease in maximum velocity of caloric nystagmus. In the rotatory test, two TTS-scopolamine and di

Lesions to the vermis cerebelli in man have been reported to produce dysmetric saccades, defective smooth pursuit, and spontaneous upbeat nystagmus. From animal experiments it has been suggested that only the posterior part of the cerebellar vermis is involved in the processing of eye movements. We report the case of a patient whose anterior vermis was resected due to metastasis of a colon adenoca

The term “whiplash” already suggests difficulties in assessing this problem. Patients suffering from “whiplash” or “whiplash-associated disorders” (WAD) are defined as having been exposed to similar types of trauma or sometimes even similar mode of impact, rather than as having a certain type of lesion or set of symptoms [1, 2]. The origin of the term “whiplash” is attributed to H. Crowe [3, 4], w

A model for the interpretation of nystagmus is worked out. A lesion in the vestibular system may appear as alteration in velocity of slow viz. fast phase of nystagmus, disconjugation of the nystagmus or as dysrhythmic nystagmus. The visual system, viz. the cortical and subcortical optokinetic nystagmus seems to provide the eye-head coordinates and retical error velocity to calibrate or cancel the

The response pattern of 109 floccular cells of alert, intact cat was examined during different proprioceptive, vestibular and visual tasks. In 62 neurons covergence of at least two sensory modalities could be confirmed. 14 of these cells responded to vestibular, visual and proprioceptive stimuli. Saccadic neurons responded to ipsi- and contralateral saccades, but with somewhat different latency an

Dizziness and subjective balance disturbances are frequent complaints in cervical pain syndromes of different origins. We objectively assessed balance function with posturography using vibration-induced and galvanically induced body sway in consecutive patients with cervicobrachial pain syndrome of more than 3 months duration. Both a group of patients with MRI-verified cervical root compression (C

There are several modes of adaptation to postural perturbations used to withstand balance disturbances and reduce the effects of muscle fatigue. We summarize experimental results, which demonstrate that there are several modes of adaptation to postural perturbations, and we discuss the properties of these adaptive processes. The presented findings suggest that patients with balance disorders would

The executive committee of the European Society for the clinical evaluation of balance disorders meets annually to address equilibrium problems that are not well understood. This is a review paper on discussions in the latest meeting we held. Materials and methods: Seeing patients with vestibular disorders who end up depending on visual information as part of their compensation process is a common