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Non-linear FE-Analysis of stress redistribution in a deep beam

Design of discontinuity regions in reinforced concrete is today often performed with Strut and Tie Method (STM) or linear finite element analyses (LFEA). However, it is questionable to what extent these design methods are appropriate with regard to resistance, ductility, serviceability and economic reinforcement arrangement. In design with STM a simple equilibrium model based on plasticity theory

High-pT jet energy scale uncertainty from single hadron response with the ATLAS detector

The jet energy scale (JES) uncertainty is estimated using different methods at different pT ranges. In-situ techniques exploiting the pT balance between a jet and a reference object (e.g. Z or gamma) are used at lower pT, but at very high pT (> 2.5 TeV) there is not enough statistics for such in-situ techniques. A low JES uncertainty at high-pT is important in several searches for new phenomena, e

Short- and long-term responses of nourishments : Barra-Vagueira coastal stretch, Portugal

Dredged material resulting from deepening and maintenance activities of the Aveiro Harbor inlet channel, northwestern coast of Portugal, has been used to mitigate the erosion trend recorded on nearby beaches (from Barra to Costa Nova Beach) through direct placement of sand by using standard dredge equipment. The disposal activities of dredged material have been undertaken at two main sites: betwee

Electrochemical flow-ELISA for rapid and sensitive determination of microcystin-LR using automated sequential injection system

An amperometric immunoanalysis system based on monoclonal antibodies immobilized on Sepharose beads and packed into a micro-immunocolumn was developed for the quantification of microcystin-LR. Microcystin-LR (MCLR) was used as a reference microcystin variant. Inside the immunocolumn, free microcystins and microcystin-horseradish peroxidase (tracer) were sequentially captured by the immobilized ant

Biological Structures

Neutron scattering methods are excellent for probing the detailed structure of biological systems, which rely on the intricate interplay of a large number of molecules from proteins and nucleic acids to lipids, hormones, and metabolites. With recent instrument developments and emergence of both new neutron sources and techniques, many biological systems that are not yet amenable to characterizatio

A finite deformation continuum modelling framework for curvature effects in fibre-reinforced nanocomposites

Motivated by experimental findings on one-dimensional nano-materials, this contribution focusses on the elaboration of a fibre curvature based higher-order gradient contribution to the stored energy function in a finite deformation setting. The presented approach is based on the fundamental theoretical developments for fibre-reinforced composites presented by Spencer and Soldatos (2007), which tak

Age but not Philadelphia positivity impairs outcome in older/elderly patients with acute lymphoblastic leukemia in Sweden

Objectives: Older/elderly patients with acute lymphoblastic leukemia (ALL) are poorly represented in clinical trials. Methods: Using Swedish national leukemia registries, we investigated disease/patient characteristics, treatment choices, outcome, and the impact of an age-adapted protocol (introduced in 2009) in this population-based study of patients aged 55-85 years, diagnosed with ALL 2005-2012

STOP smoking and alcohol drinking before OPeration for bladder cancer (the STOP-OP study), perioperative smoking and alcohol cessation intervention in relation to radical cystectomy : Study protocol for a randomised controlled trial

Background: To evaluate the effect of a smoking-, alcohol- or combined-cessation intervention starting shortly before surgery and lasting 6 weeks on overall complications after radical cystectomy. Secondary objectives are to examine the effect on types and grades of complications, smoking cessation and alcohol cessation, length of hospital stay, health-related quality of life and return to work or

Spatial planning and electric vehicles. A qualitative case study of horizontal and vertical organisational interplay in southern Sweden

The use of electric-powered vehicles (EV) is experiencing a boom in some countries. Much research has been conducted on the technology per se; however, there is a research gap regarding institutional spatial planning practice concerning EVs. Here, an empirical analysis was made of planners’ interpretations of opportunities and obstacles to integration of EVs in southern Sweden. The results reveale

Systematics of quark/gluon tagging

By measuring the substructure of a jet, one can assign it a “quark” or “gluon” tag. In the eikonal (double-logarithmic) limit, quark/gluon discrimination is determined solely by the color factor of the initiating parton (CF versus CA). In this paper, we confront the challenges faced when going beyond this leading-order understanding, using both parton-shower generators and first-principles calcula

'All they do is win' : Lessons learned from use of a serious game for Circular Economy education

This paper aims to explore how learning about Circular Economy (CE) may be facilitated through the use of the serious game In the Loop. Despite the growing literature base related to CE, academic reflection on education for a CE is currently limited. In the Loop was developed to provide an experiential learning situation for educating about material criticality and CE. This study reflects on the u

Palmitoylation of Ca2+ channel subunit CaVβ2a induces pancreatic beta-cell toxicity via Ca2+ overload

High blood glucose triggers the release of insulin from pancreatic beta cells, but if chronic, causes cellular stress, partly due to impaired Ca2+ homeostasis. Ca2+ influx is controlled by voltage-gated calcium channels (CaV) and high density of CaV in the plasma membrane could lead to Ca2+ overload. Trafficking of the pore-forming CaVα1 subunit to the plasma membrane is regulated by auxiliary sub

Status and developments of event generators

Event generators play a crucial role in the exploration of LHC physics. This presentation summarizes news and plans for the three general-purpose pp generators HERWIG, PYTHIA and SHERPA, as well as briefer notes on a few other generators. Common themes, such as the matching and merging between matrix elements and parton showers, are highlighted. Other topics include a historical introduction, from

PIWI-interacting RNAs as novel regulators of pancreatic beta cell function

Aims/hypothesis: P-element induced Wimpy testis (PIWI)-interacting RNAs (piRNAs) are small non-coding RNAs that interact with PIWI proteins and guide them to silence transposable elements. They are abundantly expressed in germline cells and play key roles in spermatogenesis. There is mounting evidence that piRNAs are also present in somatic cells, where they may accomplish additional regulatory ta

Solute transfer in on-line analytical flow-through dialyzers

Mass transfer in infinite parallel-plate dialyzers with co-flow between sample and detector streams is discussed for three different theoretical models. Analytical solutions with coupled diffusion and membrane transfer equations were obtained for plug flow in both channels. The finite-difference approximation method was used to obtain numerical solutions for a laminar-flow regime. Results obtained

Teachers’ Assessment and grading Practices in upper secondary Science Classrooms in Sweden : The Teachers’ and Students’ Perspectives

This dissertation acknowledges that accountability of educators for the grades they assign is a part of the foundation for a meritocratic society, based on fairness in judging merit and, therefore, in assigning grades. In this view, any grade obtained by any student must be both reliable and valid. This, in turn, implies that the process of assessment of students’ work on which the grade is based

Characterization and micromechanical modelling of microstructural heterogeneity effects on ductile fracture of 6xxx aluminium alloys

Ductile failure of three 6xxx serie aluminium alloys has been characterized and modelled for about thirty hardening conditions each. These alloys involve relatively similar composition and volume fraction of second phase particles. The tensile mechanical properties show the expected decrease of fracture strain with increasing strength but also major differences among the different alloys with a fa