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Background Alpha-1-antitrypsin (A1AT) deficiency is the only recognised genetic risk factor for chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality worldwide. Since A1AT is the major inhibitor of neutrophil elastase (NE), this enzyme has become widely implicated in the pathogenesis of COPD in general; however, there is currently no specific biomarker for its pr

To compare 2D transperineal ultrasound assessment of cervical dilatation with vaginal examination and to investigate intra-observer variability of the ultrasound method.

Inclusive charm and beauty cross sections are measured in e (-) p and e (+) p neutral current collisions at HERA in the kinematic region of photon virtuality 5a parts per thousand currency signQ (2)a parts per thousand currency sign2000 GeV2 and Bjorken scaling variable 0.0002a parts per thousand currency signxa parts per thousand currency sign0.05. The data were collected with the H1 detector in

INTRODUCTION: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity=H) and met (low activity=L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD

Allvarliga fuktproblem i ytterväggar med regelstomme av trä och fasadskikt av puts på isolering har under senare delen av 2000-talet konstaterats i Sverige. Ett alternativ byggsätt för den putsade fasaden är att putsa mot ett skivunderlag som sitter monterat mot läkt så att en luftspalt bildas. Om spalten i över- och underkant kan kommunicera med utomhusluften så kommer vind och temperaturskillnad

We study multiple electron transfer from a CdSe quantum dot (QD) to ZnO, which is a prerequisite for successful utilization of multiple exciton generation for photovoltaics. By using ultrafast time-resolved spectroscopy we observe competition between electron injection into ZnO and quenching of multiexcitons via Auger recombination. We show that fast electron injection dominates over biexcitonic A

A recent report of the EuroHeart project has shown that women are still underrepresented in many cardiovascular clinical trials, while important gender differences are present within most areas of heart disease. As the burden of cardiovascular disease is increasing in middle-aged women relative to men, a more profound understanding is needed of the fundamental biological differences that exist bet

This study examined mortality and predictors of death in 1,396 primary amphetamine users (85% males) who were interviewed with the Addiction Severity Index in the Swedish criminal justice system during 2000-2006 and followed through 2008. Forty-nine clients deceased (standardized mortality ratio 4.1 [3.0-5.4]), at least 84% of deaths were violent or drug-related (12% suicides), and Cox regression

Coulomb-excitation experiments are performed with postaccelerated beams of neutron-deficient Po-196,Po-198,Po-200,Po-202 isotopes at the REX-ISOLDE facility. A set of matrix elements, coupling the low-lying states in these isotopes, is extracted. In the two heaviest isotopes, Po-196,Po-198, the transitional and diagonal matrix elements of the 2(1)(+) state are determined. In Po-196,Po-198 multiste

The article discusses the impact of comparative/historical philology upon the question of nuclear semiotics, i.e. the field of how humanity is to communicate information about nuclear waste storage into the distant future and its (presumably human) inhabitants. It also turns this perspective on its head and discusses possible insights in the other direction – what Nuclear Semiotics can teach histo

Objective. To analyse the management of muscle-invasive bladder cancer in a population-based national register, and specifically to investigate the role of curative therapy (i.e. cystectomy or radiotherapy) in relation to patient, tumour and hospital characteristics. Material and methods. The Swedish Bladder Cancer Register covers more than 90% of all patients in the country who have been diagnose

Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves disease (GD), systemic lupus erythematosus (SLE), type 1 diabetes (T1D). celiac disease (CD), myasthenia gravis (

Several studies have proposed aerobic methane (CH4) emissions by plants. If confirmed, these findings would further increase the imbalance in the global CH4 budget which today underestimates CH4 sinks. Oxidation by OH-radicals in the troposphere is the major identified sink followed by smaller contribution from stratospheric loss and oxidation by methano- and methylotrophic bacteria in soils. This

This dissertation deals with antique warfare in general and late Roman warfare in particular. The overall aim is to discuss the concept of strategy in the archaeological and historical reconstruction, based on Edward N. Luttwak’s groundbreaking work The Grand Strategy of the Roman Empire (1976). Luttwak’s influence on various provincial Roman research fields cannot be underestimated, but the book