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Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase, E.C. 3.6.1.23) catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate and is involved in nucleotide metabolism and DNA synthesis. A crystal of the recombinant E. coli enzyme, precipitated from polyethylene glycol mixtures in the presence of succinate at pH 4.2, was used to collect synchrotron diffraction data to 1.9 Å resolution, in sp
A transition to environmentally sustainable societies should involve a significant and comprehensive — strategic—change. Much of the promise of SEA is associated precisely with its perceived capacity to facilitate such a strategic transformation by influencing selected ‘strategic decisions’. This paper examines the potential effectiveness and limitations of such an approach in light of contemporar
Sub-picosecond laser pulse driven localization of electronic excitation energy is suggested for a biological chromophore complex. Based on an exciton model of the photosynthetic core antenna PSI of Synechococcus elongatus the shape of the respective laser pulse is calculated using optimal control theory combined with a density matrix theory accounting for energy relaxation and dephasing caused by
Inclusive jet production is studied in neutral current deep-inelastic positron-proton scattering at large four momentum transfer squared Q(2) > 150 GeV2 with the H1 detector at HERA. Single and double differential inclusive jet cross sections are measured as a function of Q(2) and of the transverse energy E-T of the jets in the Breit frame. The measurements are found to be well described by calcul
Architects design work sometimes originates from a simplified view of human demands and needs, which may result in environments that do not fulfill the users requirements. This thesis refers to five different case studies where the affected users were involved in the creation of their dwellings or working environment. The issue of the thesis is that participatory design creates environments which
En byggnads täthet kan kontrolleras genom att man utför en provtryckning, under vilken läckflödet genom en provtryckningsfläkt mäts. Rapporten innehåller matematiska modeller för en vidareutveckling av provtryckningsmetoden som utnyttjar den tryckgradient som tryckskillnaden inne/ute skapar.
Popular Abstract in Swedish Föreliggande avhandling är en fallstudie vars empiriska material utgörs av kvalitativa forskningsintervjuer, deltagande observationer och textdokument. Avhandlingen uppmärksammar ett händelseförlopp på en nystartad svensk gymnasieskola. Förloppet inleds med kommunens och rektorns stora visioner för verksamheten och avslutas med att en samstämmig lärargrupp avsätter rektThis dissertation is based on a case study of a series of events at a newly started Swedish high school. The study employs a qualitative methodology comprising of interviews, participant observation and analysis of text documents. The series of events opens with the grand visions of the municipality and the school's principal for the school and concludes with the teachers at the school unanimously
An ability to interact with plasminogen or plasmin could provide micro-organisms with a mechanism for invasion. Thus, group A, C and G streptococci secrete streptokinase which binds and activates plasminogen. Some streptococci also express surface structures which bind plasminogen without causing its activation. Plasminogen-binding surface proteins were extracted from one group C and one group G s
The characterization of the incident photon beam is usually divided into its dependence on collimator setting (head-scatter factor) and off-axis position (primary off-axis ratio). These parameters are normally measured "in air" with a build-up cap thick enough to generate full dose build-up at the depth of dose maximum. In order to prevent any influence from contaminating electrons, it has been re
Popular Abstract in Swedish Avhandlingen består av en introduktion samt fyra artiklar. Avhandlingen behandlar externa kostnader till följd av väg- och järnvägstransporter. Den första artikeln skattar sambandet mellan antalet vägtrafikolyckor och antalet fordon på vägen. Fordonsflödet behandlas dels som bestående av homogena fordon och dels som bestående av bilar och lastbilar. Resultatet tyder på This thesis consists of an introductory chapter and four research papers, summarized as follows. The overall purpose is to study various external effects of the transport system; effects that are not considered (or not fully considered) today. The first paper estimates the relationship between accident frequency and homogeneous and inhomogeneous traffic flows, which is useful for calculating the
Popular Abstract in Swedish Undersökningarna som presenteras i avhandlingen behandlar mätning av produkter från och händelser i förbränningsprocessen genom att använda laserbaserade mätmetoder. Ett antal olika körfall, som HCCI och partially premixed combustion (PPC), har undersökts. I de första mätningarna som presenteras jämförs uppmätta flödesfält i cylindern med resultat från CFD och blåsriggThe work presented in this thesis deals with measuring in-cylinder combustion species and events using different laser-based diagnostic methods. A variety of engine operating modes, like HCCI and partially premixed diesel combustion, have been investigated. In the very first measurements, in-cylinder flow-fields were compared to CFD and steady-state blow rig results. After that, the ignition and
Popular Abstract in Swedish I föreliggande arbete har användandet av recirkulation av förbränningsgaser vid mager förblandad förbränning undersökts och testats i gaseldade Stirlingmotorbrännkammare. Ett förbränningssystem med en flamhållare av flamstoppstyp där man använder en ejektor för att recirkulera förbränningsgaser och för att förblanda bränsle och luft har konstruerats och provats i motortThe main objective in the research described in this thesis was to design and test the use of lean premixed combustion using combustion gas recirculation for gas fuelled Stirling engine combustors. A system using a flame-arrester type of flame-holder to stabilize the flame and an ejector system for the recirculation of combustion gas was designed and tested in the laboratory. The impact of changes
Objectives. To evaluate long-term changes in acetylcholinesterase (AChE) activity in CSF and blood following donepezil treatment in relation to the concentration of donepezil and cognition in AD patients. Methods. CSF or blood (or both) samples of a total of 104 patients with mild AD were used [MMSE score 23 +/- 0.4; age 75 +/- 1 years (mean +/- SEM); n = 53 for CSF and n = 51 for plasma/red blood
To mimic the electron donor side of Photosystem II (PSII), a number of supramolecular model complexes have been designed and synthesized. Ruthenium(II) tris-bipyridyl complexes have been used in most cases as photosensitizers, mimicking the function of P-680 in PSII. As electron donors, monomeric and dimeric manganese complexes and tyrosine have been introduced into the supramolecular systems, mod
Sulfur-containing compounds are used as rescue agents to protect normal tissue from the toxic side effects of cis-[PtCl2(NH3)(2)] (cisplatin) without affecting its anti-tumour activity. Reactions of the model complexes [Pt(dien)Cl](+) (1) and [Pt(dien)(GSMe)](2+) (2) (GSMe = S-methylglutathione) with the rescue agents glutathione (GSH), thiourea, thiosulfate, and diethyldithiocarbamate (DDTC) have
Lifetimes of high spin states in the three A = 89 isobars Nb-89, (89)MO and (TC)-T-89 have been measured via the Recoil Distance Doppler Shift technique and the fusion evaporation reactions Ni-58(Cl-35, xnypz alpha) at 120 MeV beam energy. Reduced transition probabilities for about 50 gamma transitions were extracted. The experimental branching ratios in Mo-89 and reduced transition probabilities
Ninety-eight patients, 56 suffering according to DSM-IV of unipolar depression and 42 of somatoform disorders, were compared on the Beck Depression Inventory (BDI) total scale, the subscale of Somatic complaints and the Cognitive-affective subscale. A factor analysis performed on the total group revealed five factors used to determine new subscales: Depressed mood, Somatic manifestations, Loss of
With the characterization of the total genomes of Arabidopsis thaliana and Oryza sativa, several putative plasma membrane components have been identified. However, a lack of knowledge at the protein level, especially for hydrophobic proteins, have hampered analyses of physiological changes. To address whether protein complexes may be present in the native membrane, we subjected plasma membranes is
