Background: To investigate the effects and mechanism of action of apolipoprotein M (ApoM) on the growth of breast cancer (BC) cells. Methods and results: Bioinformatics, cell experiments and animal experiments were used to verify the effect of ApoM on breast cancer cell lines and breast tumor growth in vivo. ApoM expression was significantly reduced in BC tissues, and patients with lower ApoM mRNA

Background and Objective: Fentanyl is an opioid commonly used to prevent and treat severe pain in neonates; however, its use is off label and mostly based on bodyweight. Given the limited pharmacokinetic information across the entire neonatal age range, we characterized the pharmacokinetics of fentanyl across preterm and term neonates to individualize dosing. Methods: We pooled data from two previ

This paper performs a comparative analysis to obtain the optimal cross-section shape and parameters of both pin fins and vortex generators. A novel combined structure with pin fins and vortex generators is proposed to enhance thermal performance of an integrated microchannel heat sink. Effects of nanoparticle diameter and volume fraction are investigated using Al2O3 nanofluid and DI-water as worki

Aim: To report on the results of the online international consensus process to develop the comprehensive and brief International Classification of Functioning, Disability and Health (ICF) Core Sets for adults with cerebral palsy (CP). Method: An online iterative decision-making and consensus process involved 25 experts, including clinicians and researchers working with adults with CP, an adult wit

Background Previous studies have demonstrated substantial associations between substance use disorders (SUD) and suicidal behavior. The current study empirically assesses the extent to which shared genetic and/or environmental factors contribute to associations between alcohol use disorders (AUD) or drug use disorders (DUD) and suicidal behavior, including attempts and death. Methods The authors u

The genetic basis of bird migration has been the focus of several studies. Two willow warbler subspecies (Phylloscopus trochilus trochilus and Phylloscopus trochilus acredula) follow different migratory routes to wintering grounds in Africa. Their breeding populations overlap in contact areas or “migratory divides” located in central Scandinavia and in eastern Poland. Earlier analyses demonstrated

Net zero emission pledges by countries and companies are everywhere at the moment. Most of these pledges rely on massive amounts of carbon removal, yet details on how this will transpire remain largely absent. The COP26 agreement suggests that markets will play a central role, but there are significant problems with this approach.

This paper presents a probabilistic method of record linkage, developed using the U.S. full count censuses of 1900 and 1910 but applicable to many sources of digitized historical records. The method links records using a two-step approach, first establishing high confidence matches among men by exploiting a comprehensive set of individual and contextual characteristics. The method then proceeds to

Sexual and reproductive health and rights (SRHR) and universal health coverage (UHC) are fundamental to health as a human right. One way that countries operationalise UHC is through the development of an essential package of health services (EPHS), which describes a list of clinical and public health services that a government aspires to provide for their population. This study reviews the content

The “realism of law” tried to dissolve the connections between justice as norm and justice as fact. A severe critic of Legal realism was Halvar G.F. Sundberg. He explained that the Church was not created by the State or its legal order, but the State and the legal order recognized the factual, existing Church as being also a legal institution. The State had no right to deal with the spiritual regi

This dissertation examines discourses of mental illness and sadness in women’s media culture during 2008-2018. It shows that there was an increase in conversations around mental illness in popular culture and on social media from 2015 and onwards. To understand what this increase looked like I examined three sites – women’s magazines, female celebrities, and social media – as purveyors of scripts

Iran is mainly located in the arid and semiarid climate zone and seriously affected by desertification. This is a severe environmental problem, which results in a persistent loss of ecosys-tem services that are fundamental to sustaining life. Process understanding of this phenomenon through the evaluation of important drivers is, however, a challenging work. The main purpose of this study was to p

Business models direct a firm’s activity to move in coherence with the objectives of the business. Current literature suggests business models can act as vital forces to facilitate sustain-ability transitions and highlights the urgent research call to understand the role of business model innovations in stimulating sustainability transitions. This paper addresses this research need by investigatin

Animal studies implicate meningeal lymphatic dysfunction in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease (PD). However, there is no direct evidence in humans to support this role1–5. In this study, we used dynamic contrast-enhanced magnetic resonance imaging to assess meningeal lymphatic flow in cognitively normal controls and patients with idi

Despite the availability of methods for analyzing protein complexes, systematic analysis of complexes under multiple conditions remains challenging. Approaches based on biochemical fractionation of intact, native complexes and correlation of protein profiles have shown promise. However, most approaches for interpreting cofractionation datasets to yield complex composition and rearrangements betwee