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Children who face development risks due to maternal addiction during pregnancy require extra medical and psychosocial resources

Aim: This study examined medical and psychosocial risk factors in children born to women with addiction problems during pregnancy and the children's needs for extra medical and psychosocial resources. Methods: Swedish midwives routinely screen pregnant women for drugs and alcohol and refer women with addictions to the Maternity and Child Healthcare Resource Team. We investigated the medical record

Mellan deltagande och inflytande. En kartläggning av brukarråd i Skånes kommuner

Denna rapport analyserar kommunala brukarråd rörande missbruks- ochberoendevård, äldreomsorg samt frågor kring psykiska och fysiskafunktionshinder. Rapporten utgår från en enkätundersökning av brukarråd i allaSkånes kommuner. Tjänstemän med ansvar för de kommunala brukarråden ficksvara på frågor om förekomst av brukarråd, vilka organisationer som medverkar ide olika kommunala brukarråden, vilka er

Common marmosets are sensitive to simple dependencies at variable distances in an artificial grammar

Recognizing that two elements within a sequence of variable length depend on each other is a key ability in understanding the structure of language and music. Perception of such interdependencies has previously been documented in chimpanzees in the visual domain and in human infants and common squirrel monkeys with auditory playback experiments, but it remains unclear whether it typifies primates

Risk of Synchronous and Metachronous Colorectal Cancer : Population-Based Estimates in Denmark with Focus on Non-Hereditary Cases Diagnosed After Age 50

Background and Aims: The risk of synchronous and metachronous colorectal cancer is influenced by heritable and environmental factors. As a basis for comparative studies, we provide population-based estimates of synchronous and metachronous colorectal cancer with a focus on non-heritable cases. Material and Methods: Based on data from national Danish cancer registers, we estimated the proportion of

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes : results from an exome-wide association study of albuminuria

Aims/hypothesis: Identifying rare coding variants associated with albuminuria may open new avenues for preventing chronic kidney disease and end-stage renal disease, which are highly prevalent in individuals with diabetes. Efforts to identify genetic susceptibility variants for albuminuria have so far been limited, with the majority of studies focusing on common variants. Methods: We performed an

Microscopic collectivity : The ridge and strangeness enhancement from string–string interactions

We present the microscopic model for collective effects, built on string–string interactions (string shoving and rope hadronization), recently implemented in the PYTHIA8 and DIPSY event generators. Rope hadronization is shown to give a good description of strangeness enhancement across pp, pA and AA collision systems, while string shoving qualitatively describes the ridge observed in pp collisions

Quantitative analysis of auxin sensing in leaf primordia argues against proposed role in regulating leaf dorsoventrality

Dorsoventrality in leaves has been shown to depend on the pre-patterned expression of KANADI and HD-ZIPIII genes within the plant shoot apical meristem (SAM). However, it has also been proposed that asymmetric auxin levels within initiating leaves help establish leaf polarity, based in part on observations of the DII auxin sensor. By analyzing and quantifying the expression of the R2D2 auxin senso

Defining the Sharing Economy for Sustainability

(1) Background: The sharing economy has emerged as a phenomenon widely described by academic literature to promote more sustainable consumption practices such as access over ownership. However, there exists great semantic confusion within academic literature surrounding the term “sharing economy,” which threatens the realisation of its purported sustainability potential. (2) Objective: The aim of (1) Background: The sharing economy has emerged as a phenomenon widely described by academic literature to promote more sustainable consumption practices such as access over ownership. However, there exists great semantic confusion within academic literature surrounding the term “sharing economy,” which threatens the realisation of its purported sustainability potential. (2) Objective: The aim of

Proteogenomic characterization of patient-derived xenografts highlights the role of REST in neuroendocrine differentiation of castration-resistant prostate cancer

Purpose: An increasing number of castration-resistant prostate cancer (CRPC) tumors exhibit neuroendocrine (NE) features. NE prostate cancer (NEPC) has poor prognosis, and its development is poorly understood. Experimental Design: We applied mass spectrometry–based proteomics to a unique set of 17 prostate cancer patient–derived xenografts (PDX) to characterize the effects of castration in vivo, a

Long-term follow-up of HIV-2-related AIDS and mortality in Guinea-Bissau : a prospective open cohort study

Background: HIV type 2 (HIV-2) is considered more benign and has fewer pathogenic consequences than HIV type 1 (HIV-1) for most infected individuals. However, reliable estimates of time to AIDS and mortality among those with HIV-2 infection are absent. We therefore aimed to compare the time to AIDS and mortality, and the CD4 T-cell dynamics between those infected with HIV-1 and HIV-2. Methods: We

The role of social embeddedness for remaining in non-desired workplaces and mental health consequences : Results from Scania Public Health Cohort

Aims: The aim of the study was to investigate the role of social embeddedness on and off the job in relation to remaining in non-desired workplaces (NDWs) and the development of mental health. Method: The study used questionnaire data from the Scania Public Health cohort (N=2410) that were collected in 2000 (T1), 2005 (T2) and 2010 (T3). Logistic regression models were calculated to probe how NDWs

Assessing the Intricate Balance of Intermolecular Interactions upon Self-Association of Intrinsically Disordered Proteins

Attractive interactions between intrinsically disordered proteins can be crucial for the functionality or, on the contrary, lead to the formation of harmful aggregates. For obtaining a molecular understanding of intrinsically disordered proteins and their interactions, computer simulations have proven to be a valuable complement to experiments. In this study, we present a coarse-grained model and

The Neighbourhood in Pieces : The Fragmentation of Local Public Space in a Swedish Housing Area

In this article, we investigate the transformation of local public spaces in the ethnically and socially diverse housing area Norra Fäladen during 1970–2015. After being built, the area soon faced stigmatization and became known as a problem area. This was followed by a series of investments in local public spaces aiming for a stronger appropriation of the neighbourhood by its inhabitants. The pro

“That’s Interesting!” in Entrepreneurship Research

In order for a work on entrepreneurship to be published and attract attention, it must be interesting. The aims of this study are to understand why entrepreneurship scholars perceive entrepreneurship studies as interesting, what they consider interesting, and how they distinguish themselves from management scholars in their perception of interestingness. The study is based on responses from 915 en

Levels of Narrativity in Scandinavian Bronze Age Petroglyphs

In Europe, Scandinavia holds the largest concentration of rock art (i.e. petroglyphs), created c. 5000–first century BC, many of them showing figurative and seemingly narrative representations. In this paper, we will discuss possible narratological approaches applied to these images. We might reasonably distinguish between three levels of pictorial narrativity: representations of (i) single eventsIn Europe, Scandinavia holds the largest concentration of rock art (i.e. petroglyphs), created c. 5000–first century bc, many of them showing figurative and seemingly narrative representations. In this paper, we will discuss possible narratological approaches applied to these images. We might reasonably distinguish between three levels of pictorial narrativity: representations of (i) single events

Influence of the protein and DFT method on the broken-symmetry and spin states in nitroge

The enzyme nitrogenase contains a complicated MoFe7CS9 cofactor with 35 possible broken- symmetry (BS) states. We have studied how the energies of these states depend on the geometry, the surrounding protein, the DFT functional and the basis set, studying the resting state, a one- electron reduced state and a protonated state. We find that the effect of the basis set is small, up to 11 kJ/mol. Lik