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Attosecond science enables the study of ultrafast dynamics on atomic scales, providing fundamental insights into light–matter interaction. This thesis work aims to advance the development and application of an attosecond light source capable of delivering extreme ultraviolet (XUV) pulses with exceptionally high intensity.High-order harmonic generation (HHG) is a nonlinear process where a strong la
Notch wear often determines tool life when machining stainless steel. Chemical Vapour Deposited (CVD) Al2O3/Ti(C,N) coated cemented carbide tools are the first recommendation for turning of stainless steel. The CVD coating plays a vital role in reducing and delaying tool wear progress. Hence, it is essential to understand the interaction between the initiation of notch wear and the coating degrada
In stainless steel turning, cutting tool life is often limited by excessive localised damage at the depth of cut line, known as notch wear. Previous research revealed that notch wear in CVD (chemical vapour deposition) Al2O3/Ti(C,N) coated WC-Co tools begins as a coating brittle fracture already after 0.3 m of cutting. This paper investigates the impact of cutting tools and workpiece materials on
Drawing on the quest to improve inclusion and social sustainability in urban planning process, a holistic approach on citizen participation in urban development is becoming increasingly important. One sector of society whose democratic rights remain overlooked in participatory action is children. It is therefore imperative to develop methods for processing the children’s rights to express their op
This study examines the security measures implemented by the Pahlavi government in Iran to counter criminal and terrorist activities prior to the 1979 revolution. The research explores the challenges posed by various radical and insurgent groups, including Marxist and Islamist factions, which employed tactics such as assassinations, kidnappings, and sabotage. It also analyzes the role of the Natio
Birnaviruses infect a broad range of vertebrate hosts, including fish and birds, and cause substantial economic losses in the fishery and livestock industries. The infectious pancreatic necrosis virus (IPNV), an aquabirnavirus, specifically infects salmonids. While structures on T=1 subviral particles of the birnaviruses, including IPNV, have been studied, structural insights into the infectious T
We report the use of streaming data interfaces to perform fully online data processing for serial crystallography experiments, without storing intermediate data on disk. The system produces Bragg reflection intensity measurements suitable for scaling and merging, with a latency of less than 1 s per frame. Our system uses the CrystFEL software in combination with the ASAP::O data framework. In a se
The Lysinibacillus sphaericus proteins Tpp49Aa1 and Cry48Aa1 can together act as a toxin toward the mosquito Culex quinquefasciatus and have potential use in biocontrol. Given that proteins with sequence homology to the individual proteins can have activity alone against other insect species, the structure of Tpp49Aa1 was solved in order to understand this protein more fully and inform the desig
Single Particle Imaging (SPI) with intense coherent X-ray pulses from X-ray free-electron lasers (XFELs) has the potential to produce molecular structures without the need for crystallization or freezing. Here we present a dataset of 285,944 diffraction patterns from aerosolized Coliphage PR772 virus particles injected into the femtosecond X-ray pulses of the Linac Coherent Light Source (LCLS). Ad
The possibility of imaging single proteins constitutes an exciting challenge for x-ray lasers. Despite encouraging results on large particles, imaging small particles has proven to be difficult for two reasons: not quite high enough pulse intensity from currently available x-ray lasers and, as we demonstrate here, contamination of the aerosolized molecules by nonvolatile contaminants in the soluti
We use extremely bright and ultrashort pulses from an x-ray free-electron laser (XFEL) to measure correlations in x rays scattered from individual bioparticles. This allows us to go beyond the traditional crystallography and single-particle imaging approaches for structure investigations. We employ angular correlations to recover the three-dimensional (3D) structure of nanoscale viruses from x-ray
Single-particle diffraction from X-ray Free Electron Lasers offers the potential for molecular structure determination without the need for crystallization. In an effort to further develop the technique, we present a dataset of coherent soft X-ray diffraction images of Coliphage PR772 virus, collected at the Atomic Molecular Optics (AMO) beamline with pnCCD detectors in the LAMP instrument at the
Single particle diffractive imaging data from Rice Dwarf Virus (RDV) were recorded using the Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS). RDV was chosen as it is a well-characterized model system, useful for proof-of-principle experiments, system optimization and algorithm development. RDV, an icosahedral virus of about 70 nm in diameter, was aerosolized and i
Serial crystallography (SX) at both X-ray free-electron lasers (XFELs) and synchrotrons offers the possibility to collect data at non-cryogenic temperature almost radiation damage free and enables time-resolved crystallography of irreversible reactions. The necessary steady delivery of new micron-sized crystals of biological macromolecules sets it apart from traditional single crystal macromolecul
Drought is a complex natural hazard increasing in frequency, duration, and severity worldwide. Although droughts cause both market and non-market impacts, the latter suffers from a dearth of economic studies quantifying their magnitude. In this paper, we investigated how droughts affect selected ecosystem services expected to result in welfare losses in Spain. This study is aimed at quantifying an
BACKGROUND: Shock is common in intensive care units, and treatment includes fluids, vasopressor and/or inotropic drugs, guided by hemodynamic monitoring. The aim of this study was to identify current practice for treatment of shock in Scandinavian intensive care units.METHODS: Seven-day inception cohort study in 43 intensive care units in Scandinavia. Patients ≥ 15 years old receiving more than 4
Background/Objectives: There is a lack of research examining healthcare professionals' perspectives regarding the potential of non-pharmacological solutions such as immersive virtual reality (VR). The aim of this study was to investigate opportunities and challenges related to the application of immersive virtual reality (VR) technology in patients aged 65 and older undergoing surgery with regiona
INTRODUCTION: The primary objective was to map the impact on confidence and performance on radiographic examinations among undergraduate radiography students utilizing virtual reality (VR). The secondary objective was to identify potential pitfalls to avoid in future VR implementation.METHODS: A systematic review was conducted, which included comprehensive search in nine databases. The software Co
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