Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk and the presence of large numbers of neutral variants, even in phenotypically relevant genes. Isolated populations with recent bottlenecks offer advantages for studying rare variants in complex diseases as they have deleterious varian

Purpose – The purpose of this paper is to analyze the applicability of lean accounting and throughput accounting in a company with considerable investments in advanced manufacturing technology (AMT). Design/methodology/approach – The paper compares lean accounting and throughput accounting with the traditional accounting system the company is using today. The authors investigate the differences b

To predict how organisms cope with habitat fragmentation we must understand their dispersal biology, which can be notoriously difficult. We used a novel, multi-pronged approach to study dispersal strategies in the endangered saproxylic hermit beetle Osmoderma eremita, exploiting its pheromone system to intercept high numbers of dispersing individuals, which is not possible with other methods. Mark

Organic phosphorus (P) is an important component of boreal forest humus soils, and its concentration has been found to be closely related to the concentration of iron (Fe) and aluminium (Al). We used solution and solid state P-31 NMR spectroscopy on humus soils to characterize organic P along two groundwater recharge and discharge gradients in Fennoscandian boreal forest, which are also P sorption

Gold-oxide-containing nanoparticles have been produced in a range of partial to full oxidation conditions, where the nanoparticle electronic structure and stoichiometry have been characterized. Our results indicate that with the increase of the oxidation degree in these nanoparticles the gold oxidation state possibly changes from lower oxides with monoor divalent metal to the higher oxide with the

Since the discovery of the mesoporous silica material templated by ionic surfactants and the subsequent development of materials templated by non-ionic surfactants and polymers, for example SBA-15, there has been a continuous research effort towards understanding their formation. In situ methodologies, such as Small Angle X-ray Scattering (SAXS), Small Angle Neutron Scattering (SANS), spectroscopi

Since the EU Nickel Directive came into force, concern has been raised that palladium may increasingly replace nickel in alloys used in jewellery and dentistry, and that it may cause as many allergy problems as nickel.

Topography and historical range expansion has formed a so-called migratory divide between two subspecies of willow warbler (Phylloscopus trochilus) in central Scandinavia. The autumn migratory directions of individuals assigned molecularly to both subspecies and possible hybrids were recorded using orientation cage experiments in southwest and southeast Sweden. We found pronounced differences in w

The developing high-resolution chronostratigraphy of the Cambrian provides an updated age model for various geologic and biotic events that occurred during this critical period of Earth history. Broad, time-specific patterns of lithofacies, such as organic-rich deposits, and biofacies appear to be consistent across all Cambrian paleocontinents. Records of important evolutionary events including fi

This paper assesses energy security in three long-term energy scenarios (a business as usual development, a projection of Copenhagen commitments, and a 450 scenario) as modeled in six integrated assessment models: GCAM, IMAGE, MESSAGE, ReMIND, TIAM-ECN and WITCH. We systematically evaluate potential long-term vulnerabilities of vital energy systems of four major economies: China, the European Unio

Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral b

A multifunctional diet (MFD) was previously shown to reduce blood lipids, CRP and blood pressure in a 4-week intervention under weight-maintenance conditions. Here, MFD effects were evaluated in an 8-week intervention with no restriction for weight changes.

Based on older people’s perspective, the aim of this article is to reveal how the culture of independence influences the decision-making process preceding relocation to a residential home. Since there is a predominant ideology of ageing in place in Sweden like in many other welfare states, the focus is on how a continued life in ordinary housing is justified versus how relocation to a residential

Diesel flame lift-off and stabilization in the presence of laser-ignition were numerically investigated with the method of Eulerian stochastic fields. The aim was to scrutinise the interaction between the lifted diesel flame and an ignition kernel upstream of the lifted flame. The numerical simulation was carried out in a constant-volume combustion vessel with n-heptane as fuel. The process was st

Thrombolysis is a common treatment for acute leg ischaemia. The purpose of this study was to evaluate different thrombolytic treatment strategies, and risk factors for complications.

New evidence and consensus has led to further revision of the McDonald Criteria for diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of central nervous system lesions in space and time has been simplified, and in some circumstances dissemination in space and time can be established by a single scan. These revisions simplify the Criteria, preserve their diagnos

Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk.

The effect of lattice structure on the transport of energetic (MeV) electrons in solids irradiated by ultraintense laser pulses is investigated using various allotropes of carbon. We observe smooth electron transport in diamond, whereas beam filamentation is observed with less ordered forms of carbon. The highly ordered lattice structure of diamond is shown to result in a transient state of warm d

An increased risk for diabetes mellitus (DM) adds significantly to the burden of late complications in childhood cancer survivors. Complications of DM may be prevented by using appropriate screening. It is, therefore, important to better characterise the reported increased risk for DM in a large population-based setting.