A hallmark of polycystic kidney diseases (PKDs) is aberrant proliferation, which leads to the formation and growth of renal cysts. Proliferation is mediated by cyclin-dependent kinases (Cdks), and the administration of roscovitine (a pan-Cdk inhibitor) attenuates renal cystic disease in juvenile cystic kidney (jck) mice. Cdk2 is a key regulator of cell proliferation, but its specific role in PKD r

The incidence of FIX inhibitors in severe hemophilia B (SHB) is not well defined. Frequencies of 3-5% have been reported but most studies to date were small, including patients with different severities, and without prospective follow-up for inhibitor incidence. Study objective was to investigate inhibitor incidence in patients with SHB followed up to 500 exposure days (ED), the frequency of aller

High-efficiency photocatalysts are crucial for the removal of organic pollutants and environmental sustainability. In the present work, we report on a new low-temperature hydrothermal chemical method, assisted by ultrasonication, to synthesize disruptive plasmonic ZnO/graphene/Ag/AgI nanocomposites for solar-driven photocatalysis. The plasmonic nanocomposites were investigated by a wide range of c

BACKGROUND: Perfluoroalkyl substances (PFAS) are widespread synthetic substances with various adverse health effects. Not much is known about the modes of action of PFAS toxicity, but one likely mechanism is alteration of microRNA expression.OBJECTIVES: To investigate whether PFAS exposure is associated with altered microRNA expression in serum.METHODS: We selected women from the Ronneby cohort, w

The three electromagnetic form factors for the transition from a 3/2+Σ∗ hyperon to the ground-state Λ hyperon are studied. At low energies, combinations of the transition form factors can be deduced from Dalitz decays of the Σ∗ hyperon to Λ plus an electron-positron pair. It is pointed out how more information can be obtained with the help of the self-analyzing weak decay of the Λ. In particular,

First responders to cardiac arrest depend on cardiopulmonary resuscitation to keep patients alive. A new ventilation method, phase-controlled intermittent insufflation of oxygen, was previously shown to improve heart perfusion during cardiopulmonary resuscitation in a large-animal study, outperforming the best currently known ventilation method. This paper investigates whether the advantage of the

Inhaled antibiotic treatment of cystic fibrosis-related bacterial biofilm infections is challenging because of the pathological environment of the lungs. Here, we present an "environment-adaptive" nanoparticle composed of a solid poly lactic-co-glycolic acid (PLGA) core and a mucus-inert, enzymatically cleavable shell of d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) for the site-specifi

Massive multiple-input multiple-output (MIMO) arrays are becoming critical elements in cellular base station infrastructure. We utilize the theory of characteristic modes (TCM) to design a novel tri-modal broadside antenna element which is suitable for the construction of compact massive MIMOarrays. The proposed antenna element consists of three ports which is formed by reviewing an existing compa

Filamentous fungi play a key role as decomposers in Earth’s nutrient cycles. In soils, substrates are heterogeneously distributed in microenvironments. Hence, individual hyphae of a mycelium may experience very different environmental conditions simultaneously. In the current work, we investigated how fungi cope with local environmental variations at single-cell level. We developed a method based

Pareto optimality is a concept that formalises the trade-off between a given set of mutually contradicting objectives. A solution is said to be Pareto optimal when it is not possible to improve one objective without deteriorating at least one of the other. A set of Pareto optimal solutions constitute the Pareto front. The Pareto concept applies well to the inverse planning process, which involves

In vivo dosimetry of IMRT from Copenhagen University Hospital

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Adding hydrogen atoms and protonation states to structures of membrane proteins requires successful implementation of neutron macromolecular crystallography (NMX). This information would significantly increase our fundamental understanding of the transport processes membrane proteins undertake. To grow the large crystals needed for NMX studies requires significant amounts of stable protein, but on

Route search requires a useful and accurate algorithm to calculate the distance between two objects, especially on a round surface such as the earth. This algorithm provides a considerable circle distance between two locations on a non-flat surface. The distance of the two objects is determined based on longitude and latitude. Haversine is an algorithm that can determine the distance between two o

An investigation into the implementation state of open standards in software is currently ongoing through the ISPRS/EuroSDR 'GeoBIM benchmark 2019' initiative, which kicked off earlier this year. The benchmark activity provides a way of assessing and comparing the functionality of different software packages in GIS and BIM in terms of their ability to handle standardised data (IFC and CityGML) and