Human plasma glutathione peroxidase (GSH-Px) is a distinct extracellular selenoenzyme that detoxifies hydroperoxides when used with GSH in high (mM) non-physiological concentrations. We have discovered that NADPH and human thioredoxin reductase (TR) by itself or with thioredoxin (Trx) are efficient electron donors to this human plasma peroxidase. Incubation of 0.05 microM TR with 0.25 microM GSH-P

A class of plane stress problems for incompressible materials is studied. The class concerns problems for unidirectionally reinforced thin sheets under quasi-static loading conditions. An incremental theory of plasticity and an isotropic yield condition is assumed. It is demonstrated how a corresponding antiplane strain problem can be identified, Thus solutions are readily found to a variety of prA class of plane stress problems for incompressible materials is studied. The class concerns problems for unidirectionally reinforced thin sheets under quasi-static loading conditions.

Domain swapping is observed for many proteins with flexible conformations. This phenomenon is often associated with the development of conformational diseases. Importantly, domain swapping has been observed for human cystatin C (HCC), a protein capable of forming amyloid deposits in brain arteries. In this study, the ability of short exposure to high-intensity X-ray radiation to induce domain swap

Ecological compensation is the latest member of a growing family of concepts aimed at reducing degradation of environmental quality. This and other concepts of the family – like ecosystem services, green infrastructure, and nature-based solutions – have been subject to a range of different interpretations and subsequent implementation practices. The result is a complex governance system with uncle

BACKGROUND: Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic castration-resistant prostate cancer. We evaluated the clinical benefit of abiraterone acetate plus prednisone with androgen-deprivation therapy in patients with newly diagnosed, metastatic, castration-sensitive prostate cancer.METHODS: In this double-blind, placebo-contro

THE DISPLACEMENT rate is given for a mode III crack growing in a steady state under dynamic conditions. The material is assumed to be visco-plastic and high strain rates are considered. A regular perturbation expansion is performed. First-order perturbing strains are, with one exception, square root singular near the crack-tip. For overstress exponents less, or equal to 2, a reasonably large regioTHE DISPLACEMENT rate is given for a mode III crack growing in a steady state under dynamic conditions. The material is assumed to be visco-plastic and high strain rates are considered. A regular perturbation expansion is performed. First-order perturbing strains are, with one exception. square root singular near the crack-tip. For overstress exponents less. or equal to 2, a reasonably large regio

Active surveillance (AS) is broadly described as a management option for men with low-risk prostate cancer, but semantic heterogeneity exists in both the literature and in guidelines. To address this issue, a panel of leading prostate cancer specialists in the field of AS participated in a consensus-forming project using a modified Delphi method to reach international consensus on definitions of t

The current status of crack tip characterizations is reviewed. Several unresolved areas for further research are identified. Singular fields for stationary and moving crack tips in different non-linear materials are reviewed and special emphasis is put on the extension of the region where these fields dominate. The use of path-area integrals, asymptotically elastic crack tips, and crack initiation

At self-similarity the strain history is implicit in and deducible from the strain field at each instance of the loading process. This fact is taken advantage of in a FEM-technique which allows the load to be applied in one single step, only, even when the incremental theory of plastic flow has to be used. Two self-similar problems are solved. Firstly an analytically solvable anti-plane strain craAt self-similarity the strain history is implicit in and deducible from the strain field at each instance of the loading process. This fact is taken advantage of in a FEM-technique which allows the load to be applied in one single step, only, even when the incremental theory of plastic flow has to be used.Two self-similar problems are solved. Firstly an analytically solvable anti-plane strain crac

Crude Distillation Unit (CDU) represents significant challenge for retrofitting and energy optimisation as the most energy intensive consumer in a conventional crude oil refinery. Pinch Technology and its based-methodologies are found primary keys for decades to energy savings in refining industries for a range of common economic-based and environmental objectives or applications. Typical benefits

Background: The influence of gender on bipolar disorder is controversial and it is unclear if inpatient care differs between men and women. Here, we investigate for gender differences in the inpatient length of stay for Swedes admitted for bipolar disorder and explore other factors that could explain any observed association. Methods: Admission data were extracted from the Swedish National Patient

Within a period of ten years a large number of schools need to be built in Sweden and these new schools need to be nearly zero energy buildings. School classrooms are required to provide healthy learning environments to help children perceive and process information. This means that classrooms must provide adequate levels of indoor air quality and thermal comfort. This article investigates CO2 con

During World War II, Nils Hylander worked on his monumental theses about the wood lawn neophytes [German: Grassameneinkömmlinge] of Swedish parks. Most probably, the original aim was to date and locate the sources of the imported seed that had obviously been widely used in the 1800’s for establishing lawns in parks of the English style, but due to restrictions to work and travel during the war, Hy

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), are autoimmune conditions associated with small vessel inflammation. Earlier studies indicate that complement activation via the alternative pathway plays a major role in the pathogenesis. In this study we have investigated if ANCA-activati

Background: Careful assessment of the reasons for discontinuation of active surveillance (AS) is required for men with prostate cancer (PCa). Objective: Using Movember's Global Action Plan Prostate Cancer Active Surveillance initiative (GAP3) database, we report on reasons for AS discontinuation. Design, setting, and participants: We compared data from 10 296 men on AS from 21 centres across 12 co

Importance: Drug company payments to health care organizations can create conflicts of interest. However, little is known about such financial relationships, especially outside the United States.Objective: To examine the concentration and patterns of drug company payments to health care organizations in the United Kingdom.Design, Setting, and Participants: This cross-sectional study examined nonre