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Statistical Analysis Plan (SAP) for the KANON-Study

STUDY SYNOPSIS Anterior cruciate ligament (ACL) injuries are common, severe and disabling knee injuries occurring in young active athletes. Treatment could be either surgical or non-surgical,both involving extensive rehabilitation for at least 4-6 months. Two RCTs comparing surgical and non-surgical treatment of ACL injured knees was performed in the 80’s and both failed to present any difference

Pharmacological Modulation of Skeletal Homeostasis

Popular Abstract in Swedish Benskörhet (osteoporos) är en sjukdom, som leder till att benstommen förlorar en del av sitt kalkinnehåll och sin styrka. Benbrott kan därigenom uppstå spontant eller vid lättare påfrestningar. Gastrektomi (kirurgiskt avlägsnade av magsäcken, GX) och ovariektomi (kirurgisk avlägsnade av äggstockarna, OVX) leder till benskörhet hos människa såväl som hos försöksdjur. MedBoth ovariectomy (OVX) and gastrectomy (GX) cause osteopenia in several animal species including humans. While the effect of OVX has been ascribed to estrogen deficiency, the underlying mechanism behind GX-induced osteopenia is poorly understood. Nutritional deficiencies, including lack of calcium and vitamin D, have been claimed to cause the osteopenia induced by GX. This thesis attempts to clari

Genetic Analysis of Cytosolic PGI in Festuca ovina

Popular Abstract in Swedish Mitt försöksmaterial utgjordes av Festuca ovina, fårsvingel, som är ett mycket vanligt gräs och tillhör familjen Poaceae. Fårsvingel är en perenn korsbefruktare och spridd över den tempererade zonen i Euroasien och Nordamerika. Släktet Festuca är uppdelat i smalbladiga svinglar, dit fårsvingel hör, och bredbladiga svinglar. Släktet Lolium, dit rajgräsen hör, är en nära Festuca ovina, sheep's fescue is a widely distributed perennial outbreeder that belongs to the grass family Poaceae and is very common in the northern temperate zone. The genus Festuca s.l. is partitioned into fine-leaved fescues to which F. ovina belongs, and broad-leaved fescues to which the genus Lolium is a close relative. Wide crosses within the Festuca-Lolium complex often yield fertile hybr

The Prometheus Complex : Striving for competence

Popular Abstract in Swedish Syftet med föreliggande undersökningar var att söka nå en mer fullständig kunskap om barn och ungas eldsanläggelse; att undersöka hur frekvent förekommande det är, samt om det, i experimentella studier, kan relateras till frustration eller leda och till personlighetsdrag som optimism, pessimism och kreativitet. Avhandlingen består av fyra studier, två intervjuundersökniThe purpose of the present investigations was to obtain a more comprehensive view of fire setting by children and adolescents; to explore the prevalence of the phenomenon; whether or not it experimentally may be related to frustration or boredom and to examine the role of personality traits such as optimism, pessimism and creativity. This dissertation consists of two experimental and two interview

Concurrent Development of Product and Packaging - Towards an Integrated Development Procedure

The global company operates from a number of locations worldwide, which entails geographical distances and logistical implications for product and parts transported, as well as the choice of product variety because of numerable worldwide consumer preferences. In these companies, packaging becomes a frequently used object to complement product features and achieve an effective and efficient means o

Environmental Barriers and Housing Accessibility Problems Over a One-Year Period in Later Life in Three European Countries

The objective of this study was to describe environmental barriers and investigate the nature of accessibility problems in housing among single-living, very old people (N = 1,150) in urban regions in three European countries (Sweden, Germany, Latvia), in a one-year perspective. A specific feature of this study is the explicit conceptual differentiation between environmental barriers and accessibil

Inference for Non-linear Diffusions and Jump-Diffusions: A Monte Carlo EM approach

We propose a simple, general and computationally efficient algorithm for maximum likelihood estima- tion (MLE) of parameters in diffusion and jump-diffusion processes. This is conducted within a Monte Carlo EM-algorithm, where the smoothing distribution is computed using resampling. The results are encouraging as we can approximate the MLE well for the models studied when using simulated data. We