PURPOSE. To examine in rodent models of retinitis pigmentosa (RP) the expression of the neuroprotectants metallothionein-I and -II and of megalin, an endocytic receptor that mediates their transport into neurons. METHODS. Gene and protein expression were analyzed in retinas of rd1 and rds mice and in those of RCS (Royal College of Surgeons) rats of various ages. Glial cell markers (cellular retina

Owing to the introduction of new diagnostic procedures, such as computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT), the individual dose caused by medical exposures has grown rapidly in the last years. This is especially a subject to radiation protection for nuclear medical diagnosis, since in this case radiopharmaceuticals are admini

The dinosaur fauna of the palynologically dated lower Berriasian Skyttegard Member of the Rabekke Formation on the Baltic island of Bornholm, Denmark, is represented by isolated tooth crowns. The assemblage is restricted to small maniraptoran theropods, assigned to the Dromaeosauridae incertae sedis and Maniraptora incertae sedis. The dromaeosaurid teeth are characterized by their labiolingually c

The B(E2;0+2+) value in 68Ni has been measured using Coulomb excitation at safe energies. The 68Ni radioactive beam was postaccelerated at the CERN on-line isotope mass separator (ISOLDE) facility to 2.9 MeV/u and directed to a 108Pd target. The emitted rays were detected by the MINIBALL detector array. Not only directly registered but also indirectly deduced information on the nucleus emitting th

A key component in successfully managing software products is to properly, and in a timely manner, identify and secure competitive advantage by innovation via feature differentiation. Although open source software (OSS) is not a new idea, several product development companies that operate in a market-driven context have started to use open source solutions as core software components in their prod

In this article it is argued that common sense morality in many cases leads to suboptimal consequences and that human beings in general put too much faith in their moral intuitions. In the first section an explanation of common sense moral is offered. In the second section a working definition of “better world” is presented. In section three, contemporary psychological research concerning human mo

Background: The digestion of food is known to alter the hemodynamics of the body significantly. The purpose of this study was to study the postprandial changes in stroke volume (SV), cardiac output (CO) and left ventricular (LV) longitudinal systolic and diastolic functions measured with tissue Doppler imaging, in relation to gastric emptying rate (GER), satiety, and glucose and insulin concentrat

Introduction: Despite the high incidence of appendicitis, the diagnosis is often delayed in children. A delayed diagnosis may lead to perforation and formation of an abscess. The treatment of an appendiceal abscess is still a debatable subject and studies have not agreed on what strategy to use. Some prefer immediate operation, whereas others advocate conservative management with or without interv

This text deals with the phenomenon of today’s rune carvers in the Nordic area. By using symbols of antiquity in their craftsmanship, the rune carvers revive an act that is historically significant and bears aspects of identity in the past as well as today. Why do people carve and erect runes stones today? When and where is it done? What are the explicit or implicit purposes? The text tries to ans

Ciliate assemblages play a significant role in the microbial food web. The effects of environmental temperature on assemblage composition may be influenced by abiotic factors such as seasonality and disturbance, but the effects of temperature on ciliate assemblages found on different substrata have not been explored. Sandy bottoms and submerged rocks harbour dissimilar ciliate assemblages, and it

Recension av Sam Nilsson, T-kontoret. Underrättelsetjänst och västsamarbete.

This paper proposes a typology for provider roles in defining business services. The starting point of the study is the underlying rationale of much of the service purchasing literature that buyers have or can easily access the necessary know-how to procure business services. If this does not hold, the implication is that buying firms would shy away from buying complex services. An alternative per

BACKGROUND: Gonadotropin-releasing hormone (GnRH) antagonists have been reported to have beneficial effects on lower urinary tract symptoms in patients with benign prostatic hyperplasia. OBJECTIVE: Our aim was to investigate the effects of ganirelix, a GnRH receptor antagonist, on bladder function and detrusor overactivity (DO) in female rats. DESIGN, SETTING, AND PARTICIPANTS: Female Sprague-Dawl

Abstract in UndeterminedBackgroundCaldicellulosiruptor saccharolyticus has the ability to produce hydrogen (H2) at high yields from a wide spectrum of carbon sources, and has therefore gained industrial interest. For a cost-effective biohydrogen process, the ability of an organism to tolerate high partial pressures of H2 (PH2) is a critical aspect to eliminate the need for continuous stripping of

Purpose: To evaluate typing and pointing performance and improvement over time of four able-bodied participants using an intra-oral tongue-computer interface for computer control. Background: A physically disabled individual may lack the ability to efficiently control standard computer input devices. There have been several efforts to produce and evaluate interfaces that provide individuals with p

Acanthamoeba species are widely distributed free-living amoebae showing an increased role as human pathogens causing encephalitis, keratitis, pneumonitis and dermatitis. A haematopoietic stem cell transplanted (HSCT) patient developed purulent meningitis while awaiting regrafting. The meningitis was thought to be an endogenous infection arising from the mucous membranes primarily involving the cer

Background: The Toll-like receptor proteins are important in host defense and initiation of the innate and adaptive immune responses. A number of studies have identified associations between genetic variation in the Toll-like receptor genes and allergic disorders such as asthma and allergic rhinitis. The present study aim to search for genetic variation associated with allergic rhinitis in the Tol

The aims were to analyze the first incidence, age-at-onset, prevalence and personality related predictors of psychotic disorders in the Lundby population (n=3563) – a community population followed through four waves of field study 1947-1997. Case ascertainment included interviews, registers, case notes and key informants. Consensus diagnoses of mental illness were assessed according to a classifi

The influence of soil physicochemical properties on microbial communities can be large, especially in developing soils of glacier forefield chronosequences. However, small-scale expositional differences in bare soils and their impacts on soil microbial communities have so far been largely neglected. Here we studied the changes of microbial communities in three deglaciated unvegetated sites along a