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Empirical Estimates of the Lead Time Distribution for Prostate Cancer Based on Two Independent Representative Cohorts of Men Not Subject to Prostate-Specific Antigen Screening.

BACKGROUND: Lead time, the estimated time by which screening advances the date of diagnosis, is used to calculate the risk of overdiagnosis. We sought to describe empirically the distribution of lead times between an elevated prostate-specific antigen (PSA) and subsequent prostate cancer diagnosis. METHODS: We linked the Swedish cancer registry to two independent cohorts: 60-year-olds sampled in 1

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Om den amerikanska insatsen i Mogadishu 1993 så som den återges i filmen Black Hawk Down.

Growth dynamics of tree-line and lake-shore Scots pine (Pinus sylvestris L.) in the central Scandinavian Mountains during the Medieval Climate Anomaly and the early Little Ice Age

Trees growing at their altitudinal or latitudinal distribution in Fennoscandia have been widelyused to reconstruct warm season temperatures, and the region hosts some of the world’slongest tree-ring chronologies. These multi-millennial long chronologies have mainly beenbuilt from tree remains found in lakes (subfossil wood from lake-shore trees). We used aunique dataset of Scots pine tree-ring dat

Combined portal vein embolization and preoperative chemotherapy prior to liver resection for colorectal cancer metastases.

Objective: Compare perioperative course and long-term mortality after liver resection for colorectal cancer (CRC) metastases between patients who had preoperative treatment with portal vein embolization (PVE) and chemotherapy or chemotherapy alone. Methods: Among patients undergoing liver resection for CRC metastases following preoperative chemotherapy treatment, 17 patients who had received pre

Duration of colonization with extended-spectrum beta-lactamase-producing Escherichia coli in patients with travellers' diarrhoea.

Background: Resistant Enterobacteriaceae have become a worldwide epidemic during the last decade and are a great threat to health care worldwide. International travel is a major risk factor for becoming colonized with extended-spectrum beta-lactamase (ESBL)-producing bacteria. Data on the persistence of colonization with ESBL-producing bacteria in the faecal flora are limited.Methods: A prospectiv

In situ bending of thoracic stent grafts: Clinical application of a novel technique to improve conformance to the aortic arch.

PURPOSE: A straight thoracic stent graft often complies poorly with the curvature of the aortic arch. We have previously reported an in vitro model of a modified stent graft that can be bent in situ after deployment to improve conformance to the aortic arch. We now report the first clinical experience with this technique in three consecutive patients. METHODS: Between September 2007 and August 200