Popular Abstract in Swedish Vår arvsmassa (DNA) finns packad i cellkärnan i de flesta kroppsceller i form av 46 kromosomer (23 par). Könscellerna innehåller ett halverat antal kromosomer. Det korrekta kromosomtalet hos människa beskrevs i Lund 1956, av Tjio och Levan. Kromosomerna innehåller tillsammans 50000-100000 gener, vilka är de delar av DNA-strängen som kan avläsas till proteiner. Cancer ärIn the present thesis benign breast lesions of various histologies, i.e., fibrocystic lesions from women with and without a known hereditary predisposition to breast cancer, fibroadenomas, phyllodes tumors, and papillomas were cytogenetically investigated with the aim to characterize the chromosomal patterns, and to relate the findings with those in breast carcinomas. No lesion-specific aberration

One of Scanias earliest castles, Grevlunda, has been reinvestigated. The first excavation in 1913 gave an interesting result but the time was not ripe for understanding what really was found. In 2002 archaeologists in corporation with historians, and culture geographers found out that the Grevlunda was a motte of a rare construction. The pottery material gave a dating to the late 12:th century. Th

Ferromagnetic Single Electron Transistors (F-SETs) comprise ferromagnetic electrodes connected to a ferromagnetic- or non-magnetic central island via tunnel barriers. These devices are important for studies of spin-transport physics in confined structures. Here we describe the development of a novel type of AFM-assembled nano-scale F-SETs suitable for spin-transport investigations at temperatures

Soils beneath former dry cleaning sites are often contaminated with the chlorinated hydrocarbons PCE and its degradation products, which are highly toxic and cancerogenic. In this study, resistivity and time domain induced polarization (DCIP) were measured at a former dry cleaning site in order to investigate if the source contamination of PCE could be detected. 80 meter long 2D-profiles were meas

Pulsed low energy positron beams provide a unique and non-destructive tool to depth probe the free volume of polymers at surfaces and interfaces. Since the employment of low energy positron beams in polymer research is an emerging technique, some focus in this thesis has been on extracting methods and equations needed to interpret the experimental data. The polymers chosen for this study were sele

The ages of the oldest stars in the Galaxy indicate when star formationbegan, and provide a minimum age of the Universe. Radioactive dating ofmeteoritic material and stars relies on comparing the present abundanceratios of radioactive and stable nuclear species to the theoreticallypredicted ratios of their production. The radioisotope 232 Th (half life14 Gyr) has been used to date Galactic stars,

Evacuation model capabilities are rapidly improving, allowing the simulation of ever more complex scenarios in different types of environments. The definition of the best evacuation modelling approach for safety assessment is a key point for optimizing engineering work and ensuring the desired safety conditions. In the present thesis, a wide comparison between modelling approaches has been provide

In this paper the historically persistent mismatch between the information systems development and security paradigms is revisited. By considering the human activity systems as a point of reference rather than a variable in information systems security, we investigate the necessity for a change in the information systems security agenda, accepting that a viable system would be more user-centric by

This case describes an ongoing initiative in Sweden with the aim of measuring the development of the Swedish infrastructure sector. The reason this case was chose is that it is one, of only a very few, national initiatives with a clear aim of taking an holistic approach to assess the development of one large share of the Swedish construction sector. The purpose of this case is to investigate: – Wh

This thesis is about the social services’ investigations into childrens need of protection and support. The principal purpose is, from a critical perspective, to analyse and discuss how the legally-accorded procedural directives for the execution of an investigation, and therein the integrated support and counselling work, are adapted in the social services’ actual investigation work in relation t

Popular Abstract in Swedish Sepsis (blodförgiftning) och septisk chock är ett resultat av en inflammatorisk reaktion i kroppen som helhet förorsakad av mikroorganismer. Sepsis patienterna uppvisar inte bara de vanliga tecken till infektion som feber, höjd sänka och ökat antal vita blodkroppar i blodet utan de kan även ha andra komplikationer såsom lung-, njur- och leversvikt. När sepsis orsakar ruThe present thesis focuses on the vascular effects of antimicrobial peptides especially mechanisms involving the vasodilator nitric oxide (NO), which is released from the blood vessel wall during inflammatory conditions such as sepsis. Bacterial lipopolysaccharide stimulates the expression of nitric oxide synthase (iNOS), which increases the NO production in vascular tissues or cultured vascular s

Popular Abstract in Swedish Svensk Sammanfattning Gen-förändringar i endometrie- och ovarial cancer: Endometriecancer (EC, cancer i livmoderslemhinnan) är den vanligaste gynekologiska cancerformen i västvärlden. Tumörutvecklingen kan associeras till en östrogen-inducerad stimulans av endometriets tillväxt i avsaknad av den differentierande effekten av progesteron. Den maligna cancern föregås i visEndometrial cancer is the most common gynecological cancer diagnosed in western countries. Complex atypical hyperplasia (CAH) reflects a state of hyperestrinism and its role as a precursor lesion of this cancer is established. Endometrial cancers arising in association with CAH are reported in women of younger age, with early stage disease, favorable histological types, higher progesterone recepto

The starting point of this study is the striking similarities between late modern notions of anthropogenic climate change and premodern ideas about divine punishment. In both these cases the occurrence of future disasters have been directly linked to the moral behavior of the endangered. What threatens to befall man is considered to be his own fault. Hence urgent calls have been made for each and

Att skapa sin värld är skriven för alla som bryr sig om psykologi. Framför allt för de som inte vill lämna den gömd i någon akademisk garderob utan kräver att den ska ha relevans för levande människor.

Scoliosis is an S-shaped sideways curvature of the spine leading to the shape change of the torso Idiopathic scoliosis is one form of this disease with unknown aetiology. 300 children out of 100 000 need treatment. Treatment duration is till the end of the patient’s growth age (till the ossification of the skeleton) and the brace should be worn 23 hours a day. Problems with brace are: heat, moist,