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Maladaptive striatal plasticity in L-DOPA-induced dyskinesia.

Dopamine (DA) replacement therapy with l-DOPA remains the most effective treatment for Parkinson's disease, but causes dyskinesia (abnormal involuntary movements) in the vast majority of the patients. The basic mechanisms of l-DOPA-induced dyskinesia (LID) have become the object of intense research focusing on neurochemical and molecular adaptations in the striatum. Here we review this vast litera

Asymptotic distance properties of binary woven convolutional codes

Two constructions of binary concatenated convolutional codes are considered. In our previous work [Proc. 4th Int. Symp. Commun. Theory Appl., Lake District, UK (1997)] such codes were called woven convolutional codes. In the present paper, asymptotic lower bounds on active distances of woven convolutional codes are investigated. It is shown that these distances can be bounded from below by linearl

Template Based Recognition of On-Line Handwriting

Software for recognition of handwriting has been available for several decades now and research on the subject have produced several different strategies for producing competitive recognition accuracies, especially in the case of isolated single characters. The problem of recognizing samples of handwriting with arbitrary connections between constituent characters (emph{unconstrained handwriting})

Identification and evaluation of slip and fall risk on ice and snow

Roads and pavements covered with ice and snow during winter in the Nordic and other cold regions are slippery, which result in the prevalence of slip and fall accidents among not only the public, but also outdoor workers. Literature and injury statistics revealed that the most frequently specified contributory factor for occupational slip, trip and fall accidents in Sweden is snow and ice. Road ac

Alzheimer's disease (AD) and executive dysfunction. A case-control study on the significance of frontal white matter changes detected by diffusion tensor imaging (DTI).

White matter (WM) changes are frequently seen on structural imaging in AD but the clinical relevance of these changes is uncertain. Frontal WM pathology is often observed upon neuropathological examination in AD. Since frontal cortical/sub-cortical pathology is known to relate to executive dysfunction, the aim was to elucidate if frontal WM changes in AD correlated with executive dysfunction. In a

THE EFFECT OF REDUCED BREAST COMPRESSION IN BREAST TOMOSYNTHESIS: HUMAN OBSERVER STUDY USING CLINICAL CASES.

The aim of this study was to investigate whether the compression force used with conventional mammography can be reduced with breast tomosynthesis (BT), without adversely affecting the visualisation of normal and pathological structures. Forty-five women were examined with BT using full (same as for 2D mammography) and half compression force. Both examinations were performed with the same acquisit