Resistance mechanisms against antiangiogenic drugs are unclear. Here, we correlated the antitumor and antivascular properties of five different antiangiogenic receptor tyrosine kinase inhibitors (RTKIs) (motesanib, pazopanib, sorafenib, sunitinib, vatalanib) with their intratumoral distribution data obtained by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI). In t

With the example of On Suffocation, this article problematizes how violence on film is represented and received. Ethical questions linked to the role and function of the viewer, medium and originator are at the centre of the analysis, and the writings of Susan Sontag function as conceptual backdrop.

We compare terminology used in the literature on multigrid methods for compressible computational fluid dynamics to that used in linear multigrid theory. Several popular iterative and direct smoothers are presented side-by-side using the same terminology. We argue for greater analysis of these methods in order to place them into a more rigorous framework and to identify the most promising candidat

Increased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409, which lacks both of these features. We hypothesised that obesity/insulin resistance rather than liver fat increases circulating coagulation factor activities. We measured plasma prothrombin time (PT, Owren method), activated partial thromboplastin time (APTT

Haemophilia A is a congenital bleeding disorder characterised by recurrent haemorrhages into the major joints. Haemophilic arthropathy is a well-established outcome of recurrent joint bleeding; however, it is clear that multiple factors determine the extent and severity of its occurrence. We sought to identify genetic factors related to abnormalities in range of motion (ROM) in the knees, ankles a

Aims: To investigate how training intensity influences HRQoL in people classified as obese, if HRQoL changes are related to changes in weight or aerobic capacity, and to define minimal clinically important difference (MCID).Methodology: Participants (BMI ≥35 kg/m2) randomized into high-intensity training (n = 49), moderate intensity training (n = 39), or no training (n = 22), completed the SF-36 q

Neighbourhood peer effects (social influence) in the diffusion of residential solar photovoltaics (PV) have previously been identified and quantified in a number of studies. Yet, little has been known about the inner workings of peer effects in PV diffusion. In the present work, a survey and interviews were used to study peer effects among Swedish PV adopters. Participants acknowledged peer effect

Charge transfer interactions between C60 and the metal surfaces of Ag(111), Cu(111), Au(111) and Pt(111) have been studied using synchrotron-based photoemission, resonant photoemission and X-ray absorption spectroscopies. By placing the X-ray absorption and valence band spectra on a common binding energy scale, the energetic overlap of the unoccupied molecular orbitals with the density of states o

Hypothesis Chitosan and sulfated oat β-glucan are materials suitable to create a prebiotic coating for targeted delivery to gastrointestinal system, using the layer by layer technology. Experiment Quartz crystal microbalance with dissipation (QCM-D), spectroscopic ellipsometry (SE) and atomic force microscopy (AFM) were used to assess the multilayer formation capacity and characterize the resultin

The electronic spectra of three rhombic type 1 blue copper proteins, nitrite reductase, pseudoazurin, and cucumber basic protein, have been studied by ab initio multiconfigurational second-order perturbation theory (the CASPT2 method). The six lowest excitations have been calculated and assigned with an error of less than 1800 cm-1. The singly occupied orbital in the ground-state forms a strongly

Laminar burning velocities of hydrocarbon blends of relevance to natural gas combustion, with addition of 0, 10, 35 and 50% hydrogen, were measured using the heat flux method. Hydrocarbon blends were methane (80%)/ethane (20%), methane (80%)/propane (20%) and methane (80%)/ethane (10%)/propane (10%), and in addition experiments were performed using pure methane as a fuel. For the first time it was