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Abstract Purpose: To investigate genotype-phenotype correlation and to analyze functional and structural changes in the retina of patients with von Hippel-Lindau (VHL) disease. Methods: Thirteen patients from four families (A, B, C and D) with known VHL disease and known mutations in the VHL gene were examined. All patients underwent clinical examination and optical coherence tomography (OCT). Ful
Large-scale bioethanol production from lignocellulosic biomass will require high solids loading in the enzymatic hydrolysis step. However, slurries of pretreated lignocelluloses are complex fluids due to the fibrous nature, especially at high concentrations of water insoluble solids (WIS). A prerequisite for dealing with transport issues and for developing efficient full-scale processes is a funda
Animals relying on a celestial compass for spatial orientation may use the position of the sun, the chromatic or intensity gradient of the sky, the polarization pattern of the sky, or a combination of these cues as compass signals. Behavioral experiments in bees and ants, indeed, showed that direct sunlight and sky polarization play a role in sky compass orientation, but the relative importance of
In this paper we present an improved algorithm for finding low-weight multiples of polynomials over the binary field using coding theoretic methods. The associated code defined by the given polynomial has a cyclic structure, allowing an algorithm to search for shifts of the sought minimum-weight codeword. Therefore, a code with higher dimension is constructed, having a larger number of low-weight
Repeated intra-articular bleedings in patients with haemophilia results in a crippling arthropathy for which no specific treatment is currently available. Recent studies have shown that neoangiogenesis is involved in the pathologic process. The aim of this study was to determine if angiogenesis is dysregulated in haemophilic joint disease (HJD).
The aim was to develop a new instrument for measuring length of sleep as well as television and computer habits in school-age children. A questionnaire was constructed for use when children visit the school health care unit. Three aspects of the validity of the questionnaire were examined: its face validity, content validity, and construct validity. Test-retest reliability was assessed by giving t
Photoinduced electron transfer processes in perylene-titanium dioxide dye-semiconductor systems are studied. In particular, the influence of saturated and unsaturated aliphatic spacer groups inserted between the chromophore and the semiconductor substrate is investigated. The study is based on a recently developed method that combines first-principles electronic structure calculations to character
Background: We wanted to define lung cancer incidence rates by histological subtype among immigrants in Sweden to explore the effect of new environments on the incidence of lung cancer by histological subtype in different ethnic populations. Methods: The nationwide Swedish Family-Cancer Database w used to calculate age-standardized incidence rates (ASR) (per 100,000) and standardized incidence rat
Most of the observed extrasolar planets are found on tight and often eccentric orbits. The high eccentricities are not easily explained by planet-formation models, which predict that planets should be on rather circular orbits. Here we explore whether fly-bys involving planetary systems with properties similar to those of the gas giants in the Solar system can produce planets with properties simil
A review is presented for two-phase modeling approaches to study various transport processes and reactions in polymer electrolyte membrane (PEM) fuel cells along with some experimental work. It has been noted that water management is still one of the least accurate modeled phenomena. The lackness in complete descriptive models for water management inside PEM fuel cells can be attributed to the com
To evaluate current surgical cervical cancer treatment in Sweden 2008-2012.
Density functional theory (DFT) and time-dependent DFT calculations have been performed on a set of 34 titanium dioxide clusters ((TiO2)(n) with n125) to investigate structural and electronic properties of nanostructured TiO2 (nano-TiO2) materials. The investigated clusters include models of the three low-energy polymorphic forms of TiO2 anatase, rutile, and brookite. A systematic comparison of cl
Objective-Obesity increases the risk of cardiovascular disease and premature death. However, not all obese subjects develop the metabolic abnormalities associated with obesity. The aim of this study was to clarify the mechanisms that induce dyslipidemia in obese subjects. Methods and Results-Stable isotope tracers were used to elucidate the pathophysiology of the dyslipidemia in hypertriglyceridem
Oxygen (delta O-18) and carbon (delta C-13) isotope records of calcitic carbonate components (Chara sp. algal encrustations and Bithynia tentaculata gastropod opercula) from a lake-sediment succession on the Baltic Sea island of Gotland, south-eastern Sweden, have been obtained to investigate regional climate dynamics during the Holocene. The hydrological sensitivity of the small lake, particularl
We report on an x-ray cone-beam differential phase-contrast computed laminography (DPC-CL) method for tomographic reconstruction of thin and lamellar objects. We describe the specific scan geometry of DPC-CL, which consists of a Talbot-Lau grating interferometer and a lab-based x-ray tube source, and derive a filtered back-projection (FBP) reconstruction algorithm. The experimental results of a fl
INTRODUCTION: Snakebite accidents are an important health problem in rural areas of tropical countries worldwide, including Costa Rica, where most bites are caused by the pit-viper Bothrops asper. The treatment of these potentially fatal accidents is based on the timely administration of specific antivenom. In many regions of the world, insufficient health care systems and lack of antivenom in rem
In this paper the interaction between two rigid parts of a multibody, connected by an ideal spherical joint equipped with a visco-elastic torsion bushing element, is derived. The model allows for arbitrary relative rotations of the parts and involves a non-linear torsion stiffness of the bushing. An expression for the interaction between the parts is derived and a specialization to the isotropic b
