Brazil's Atlantic Forest biome is one of the world's biodiversity hotspots, whose heterogeneous ecosystems are threatened by habitat loss and climate change. Palaeoecological research can provide essential context for the impacts of anthropogenic climate change in the 21st Century and beyond, but existing studies have notable limitations in the insights they can provide: vegetation proxy data are

Objective: To study childbirth and the risk of miscarriage and infertility among women who have received a diagnosis of type 2 diabetes before the start of their reproductive journey. Design: Register-based cohort study using the Skåne Healthcare Register Setting: All healthcare visits for the whole population of the southernmost region in Sweden over the past 20 years Patient(s): All women who we

Carbon monoxide (CO) is an odorless and colorless gas with multiple sources that include engine exhaust, faulty furnaces, and other sources of incomplete combustion of carbon compounds such as house fires. The most serious complications for survivors of consequential CO exposure are persistent neurological sequelae occurring in up to 50% of patients. CO inhibits mitochondrial respiration by specif

This paper presents a reasoned account of the critiques addressed to the circular economy and circular business models. These critiques claim that the circular economy has diffused limits, unclear theoretical grounds, and that its implementation faces structural obstacles. Circular economy is based on an ideological agenda dominated by technical and economic accounts, which brings uncertain contri

Predictive information and maintenance optimization for deteriorating structures is concerned with scheduling (a) the collection of information by inspection and monitoring and (b) maintenance actions such as repair, replacement, and retrofitting based on updated predictions of the future condition of the structural system. In this article, we consider the problem of jointly identifying—at the beg

The small intestine is a specialised organ, essential for nutrient digestion and absorption. It is lined with a complex epithelial cell layer. Intestinal epithelial cells can be cultured in three-dimensional (3D) scaffolds as self-organising entities with distinct domains containing stem cells and differentiated cells. Recent developments in bioengineering provide new possibilities for directing t

Previous studies on sustainability support the idea that the introduction of specific projects and certifications on sustainability increase the quality of wine production while specific requirements enhance environmental biodiversity and efficiency considering several aspects, such as water consumption and fertilizer use. These studies are mainly based on case studies and focus in particular on t

Clinical monitoring of blood oxygen saturation (sO2) is traditionally performed using optical techniques, such as pulse oximetry and diffuse reflectance spectroscopy (DRS), which lack spatial resolution. Photoacoustic imaging (PAI) is a rapidly developing biomedical imaging technique that is superior to previous techniques in that it combines optical excitation and acoustic detection, providing a

Neural transplantation is a potential therapeutic method for Parkinson’s disease (PD). Fetal dopaminergic (DA) neurons have been important transplantation cell sources in the history of replacement therapy for PD. Several decades of preclinical animal experiments and clinical trials using fetal DA neuron transplantation in PD therapy have shown not only promising results but also problems. In orde

Among the interesting questions related to tongue-twisters is the question how fast syllables of different types can be repeated. A simple pilot experiment with strings of open syllables such as [tatata...], [stastasta...], [strastrastra ...] was carried out. Differences in the results are interpreted as being due to individual differences in motor skills and to differences in the phonetic materia

The electrochemical oxidation (EO) of phenolic wastewaters mimicking olive oil mill effluents was carried out in a batch stirring reactor using Ti/IrO2 anodes, varying the nature (NaCl and Na2SO4) and electrolyte concentration (1.8-20 g L-1), current density (57-119 mA cm(-2)) and initial pH (3.4-9). Phenolic content (TPh) and chemical oxygen demand (COD) removals were monitored as a function of a

Background: Neuronal calcium and ATP homeostasis is regulated through alterations in mitochondria fusion/fission events and anterograde and retrograde transport in neurons. Mitochondrial dynamics form an interactome that ultimately controls mitochondrial quality, quantity and metabolism. Our objective is to show that alterations in this interactome lead to point-of-no-return situations characteriz

Stochastic sampling of light transport paths is key to Monte Carlo forward rendering, and previous studies have led to mature techniques capable of drawing high-contribution light paths in complex scenes. These sampling techniques have also been applied to differentiable rendering.In this paper, we demonstrate that path sampling techniques developed for forward rendering can become inefficient for

Cooper-Knock et al. identify amyotrophic lateral sclerosis (ALS) risk variants within non-coding regulatory DNA linked to a known ALS gene, TBK1, but also CAV1 and CAV2. Disease-associated variants reduce CAV1/CAV2 expression and disrupt membrane lipid rafts with consequences for neurotrophic signaling. CAV1 coding sequence also contains ALS-associated mutations. © 2020 The Author(s) Amyotrophic l