Filtyp
What does it mean to live with fossil fuels? Studying farmers in the sugar beet districts on the plains of Southern Scandinavia, this thesis investigates the history and ethnography of a troubled relationship between subterranean energy and everyday life. How did it come about that farmers first came to depend on fossil fuels? What changes followed in their use of the land and their gendered divis
BACKGROUND: The ORBITA and ORBITA-2 trials have provided valuable insights into the effects of coronary revascularization in chronic coronary syndrome (CCS). However, uncertainties remain regarding the efficacy of revascularization on symptoms in large real-world populations. To evaluate the efficacy of revascularization, we used dispensed long-acting nitrates as a proxy for the presence of angina
Objective: To determine bone shape changes over two years after acute anterior cruciate ligament (ACL) injury and to compare knees treated with ACL reconstruction (ACLR) vs no ACLR. Design: We used prospective data involving 129 young adults (46 % female, mean age 25 years) with recent ACL injury from a subcohort within the prospective multicenter NACOX study. Patients were treated according to S
BACKGROUND: Psychiatric patients may refer to concepts neither medically accepted nor easily understood to describe their experiences when seeking medical care. These concepts may lie outside the clinician's cultural references and consequently hinder the diagnostic consultation. In the fifth version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the clinical instrument Cult
This study investigates the practical integration of Building Information Modelling (BIM) and Building Energy Modelling (BEM) for energy-efficient building design. This research explores the challenges and opportunities of openBIM-to-BEM workflows by drawing on a literature review and a real-world case study in Östergötland County, typical of the Million Programme, a large public housing initiativ
BACKGROUND: Neuroblastoma (NB) is a childhood cancer with a high relapse rate despite intensive treatment. TRPA1 is a pain-sensing ion channel with downstream impacts on proliferative and pro-apoptotic pathways. Here, we evaluated TRPA1 expression in NB and performed pharmacological inhibition in preclinical models to assess its potential as a therapeutic target in NB.METHODS: TRPA1 protein levels
OBJECTIVES: The Sepsis-3 definition states the clinical criteria for sepsis but lacks clear definitions of the underlying infection. To address the lack of applicable definitions of infection for sepsis research, we propose new criteria, termed the Linder-Mellhammar criteria of infection (LMCI). The aim of this study was to validate these new infection criteria.DESIGN: A multicenter cohort study o
We present and analyze a hybridizable discontinuous Galerkin method for coupling Stokes and Darcy equations, whose domains are discretized by two independent triangulations. This causes nonconformity at the intersection of the subdomains or leaves a gap (unmeshed region) between them. In order to properly couple the two different discretizations and obtain a high-order scheme, we propose suitable
Article 12 of the UN Convention on the Rights of Persons with Disabilities requires states parties to take appropriate measures to ensure that persons with disabilities have access to the support they may need in exercising their legal capacity. However, this obligation remains ambiguous. What exactly is decision-making support meant to accomplish? Until this fundamental issue has been clarified,
While the 8.2 ka abrupt cooling event is increasingly recognised as a major Holocene climatic anomaly, archaeological discussions of its cultural consequences have often been framed in terms of societal distress, including the collapse and abandonment of settlements. However, prehistoric communities must have responded in more diverse ways. This paper investigates the site-based socio-ecological a
Ornamental horticultural plants in domestic gardens can constitute a substantial dispersal pool of potentially invasive species. Understanding garden owners' preferences when selecting plants, their awareness of dispersal pathways and how they manage their gardens is critical for effective invasive species control. This study used a survey to investigate Swedish garden owners' (n = 743) plant seleOrnamental horticultural plants in domestic gardens can constitute a substantial dispersal pool of potentially invasive species. Understanding garden owners' preferences when selecting plants, their awareness of dispersal pathways and how they manage their gardens is critical for effective invasive species control. This study used a survey to investigate Swedish garden owners' (n = 743) plant sele
Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previ
Electricity grids are essential to industrialized societies, yet they are increasingly unable to meet the dual demands of increased electrification and electricity system decarbonization. Smart grids offer a solution to these challenges by integrating information and communication technologies into the physical grid. However, despite their potential, smart grid implementations often fail to delive
The desire for a deeper connection with nature has become increasingly apparent. The shift towards eco-conscious living, as demonstrated by the popularity of gorpcore and the nomad lifestyle, shows that people want to make more sustainable and nature-inspired choices. In response to this cultural shift, I am motivated to channel these environmental sentiments into a design project — the creation
Over-indebtedness is at an all-time high in Sweden. The purpose of this study was to examine the relationships between financial literacy, coping strategies, and consumer financial behaviour. A further aim was to examine gender differences in this context. The study employed a cross-sectional survey design, in which participants (n = 2057) responded to questions related to the study variables. The
PARP15 is a mono-ADP-ribosyltransferase that targets an unknown set of proteins as well as RNA. Its evolutionary relationship with PARP14 suggests roles in antiviral defence; its localization to stress granules points to functions in the regulation of translation. Here we show that the transferase domain of PARP15 dimerizes in solution; the formation of dimers is a prerequisite for catalytic activ
