IDO1 can be induced by interferon gamma (IFN-γ) in multiple cell types. We have earlier described that the DNA methyltransferase inhibitor zebularine also induces IDO1 in several rat cell clones. We now describe a synergistic induction of IDO1 expression by IFN-γ and zebularine. To elucidate the mechanism of the IDO1 induction we have studied the methylation status in the promoter region of the ID

This review aims to sum up current knowledge on the sensitivity and specificity of ultrasound features suggestive of acute pelvic inflammatory disease (PID).

During the last 20 years a tremendous improvement in the care of patients with pituitary tumors and of hypopituitarism has been achieved. If we resolve most of the possible causes of the increased cardiovascular disease and stroke mortality a normal survival is expected in these patients. Recently, a large population based study showed a decline in the risk of non-fatal stroke and of non-fatal car

Autonomic computing systems are capable of adapting their behavior and resources thousands of times a second to automatically decide the best way to accomplish a given goal despite changing environmental conditions and demands. Different decision mechanisms are considered in the literature, but in the vast majority of the cases a single technique is applied to a given instance of the problem. This

Structure-activity experiments were performed for the HCl oxidation reaction (Deacon-like process) over RuO2 model catalysts - RuO2(1 1 0) and RuO2(1 0 0) - applying in situ surface X-ray diffraction (SXRD) combined with on-line mass spectrometry. The studied model catalysts turned out to be long-term stable under reaction conditions with gas feed ratios p(HCl):p(O-2) ranging from 1:4 to 4:1 in th

Introduction: Until now, studies examining the relationship between socioeconomic status and pancreatic cancer incidence have been inconclusive. Aim: To prospectively investigate to what extent pancreatic cancer incidence varies according to educational level within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: In the EPIC study, socioeconomic status at ba

Up-regulation of G-protein-coupled receptors (GPCR) plays key roles in renal hypertension and cardiovascular disease pathogenesis. The present study was designed to examine if lipid-soluble cigarette smoking particles (DSP), nicotine and endotoxin (LPS), induce GPCR up-regulation for thromboxane A(2) (TP), endothelin type A (ETA) and type B (ETB) receptors in renal artery, and if intracellular sig

This study compared the short-term efficacy of two treatments (local anesthetics (A) and local anesthetics and lavage (AL)) in patients with permanently displaced discs and temporomandibular disorder (TMD) pain. 45 patients participated in the single-blind randomized controlled trial. All patients had received: a Research Diagnostic Criteria/TMD diagnosis of disc displacement without reduction; an

This paper describes the problem of load disturbance rejection using feedforward for the case when perfect compensation is not realizable due to processes delays inversion. First, a new generalized open-loop design tuning rule for feedforward compensators is proposed. Simple and intuitive guidelines are given for aggressive, moderate, and conservative performance results. Moreover, a switching fee

Background and purpose - Fractures of the lateral malleolus often require open reduction and internal fixation (ORIF). Despite uneventful fracture healing, many patients will suffer from long-term detriments after ORIF, such as local tenderness that requires hardware removal. In Sweden, there are 2 major fixation methods, either the AO method (plate and screws) or the Cedell method (cerclage wire

Parsnip (Pastinaca sativa) suspensions, at concentrations corresponding to a dilute and concentrated regime, were subjected to pasteurization, and heat treatments that favored beta-elimination reactions and pectin methyl esterase activity. The different heat treatments were combined with homogenization. Physicochemical properties such as content of insoluble/soluble material and insoluble/soluble

Standard structure tensors provide a robust way of directionality estimation of waves (or edges) but only for the case when they do not intersect. In this work, a structure tensor extension using a one-way wave equation is proposed as a tool for estimating directionality in seismic data and images in the presence of conflicting dips. Detection of two intersecting waves is possible in a two-dimensi

BACKGROUND: Increased infection risk in inflammatory rheumatic diseases may be due to inflammation or immunosuppressive treatment. The influence of tumor necrosis factor (TNF) inhibitors on the risk of developing surgical site infections (SSIs) is not fully known. We compared the incidence of SSI after elective orthopedic surgery or hand surgery in patients with a rheumatic disease when TNF inhibi

The development of neutralizing antibodies to factor VIII (FVIII) is the most serious complication of therapy for haemophilia A. There is now excellent documentation that a large number of both genetic and environmental factors contribute to the risk of FVIII inhibitor incidence. One of the environmental factors that has been proposed as an influence on this complication is the occurrence of FVIII

Diffractive excitation is usually described by the Good-Walker formalism for low masses, and by the triple-Regge formalism for high masses. In the Good-Walker formalism the cross section is determined by the fluctuations in the interaction. In this paper we show that by taking the fluctuations in the BFKL ladder into account, it is possible to describe both low and high mass excitation by the Good

Arctic sea ice decline has led to an amplification of surface warming and is projected to continue to decline from anthropogenic forcing, although the exact timing of ice-free summers is uncertain owing to large natural variability. Sea ice reductions affect surface heating patterns and the atmospheric pressure distribution, which may alter midlatitude extreme weather patterns. Increased light pen

Current research on Parkinson's disease (PD) pathogenesis requires relevant animal models that mimic the gradual and progressive development of neuronal dysfunction and degeneration that characterizes the disease. Polymorphisms in engrailed 1 (En1), a homeobox transcription factor that is crucial for both the development and survival of mesencephalic dopaminergic neurons, are associated with spora

This paper analyses the credibility of author anonymity that is provided by a double-blind review process. It is argued that authors have strong incentives to disseminate information about their papers before publication. A sample from two economics journals, both using double-blind review processes, provides evidence that author-revealing information of most accepted papers is available on the In