Sökresultat

tRNA-derived stress-induced RNAs (tiRNAs) are a new class of small non-coding RNA that have emerged as important regulators of cellular stress responses. tiRNAs are derived from specific tRNA cleavage by the stress-induced ribonuclease angiogenin (ANG). Loss-of-function mutations in the ANG gene are linked to amyotrophic lateral sclerosis (ALS), and elevated levels of specific tiRNAs were recently

Few studies have explored religious professionals’ interactions with scientific authority in work settings. Fewer still examine professionals outside Western contexts. We analyze the science-religion interface as it exists in Shaolin Temple—an ancient Chan Buddhist temple with a worldwide reputation for Shaolin Kungfu. Drawing on a near-exhaustive survey within Shaolin monastery and 23 interviews

Marriage is among the most fundamental social relationships undergirding the transmission of cultural norms and family property. How marital partnerships are formed is of considerable interest to a broad range of social scientists, particularly when and whether partners are sought from within the family or from the outside. We study the relatively high levels of cousin marriage characteristic of E

We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort to build an open access, interoperable and computable repository of COVID-19 molecular mechanisms. The COVID-19 Disease Map (C19DMa

OBJECTIVE: Sepsis and septic shock are major challenges and economic burdens to healthcare, impacting millions of people globally and representing significant causes of mortality. Recently, a large number of quality improvement programs focused on sepsis resuscitation bundles have been instituted worldwide. These educational initiatives have been shown to be associated with improvements in clinica

Combustion remains the primary process for energy supply in nowadays society. With the emerging of low-carbon fuels alongside traditional fossil fuels, the increased complexity of thermal-chemical conversion processes call for more accurate diagnostic tools. Compared to traditional offline measurement techniques which are often insufficient in providing precise information, advanced laser diagnost

Patients with non-obstructive hypertrophic cardiomyopathy (HCM) exhibit myocardial changes which may cause flow inefficiencies not detectable on echocardiogram. We investigated whether left ventricular (LV) kinetic energy (KE) and hemodynamic forces (HDF) on 4D-flow cardiovascular magnetic resonance (CMR) can provide more sensitive measures of flow in non-obstructive HCM.Methods and resultsNinety

Ti (C, N) based cermet materials are predominantly used in continuous finishing applications of metal cutting due to their high hardness, excellent resistance to oxidation and high chemical stability. However, their application in interrupted cutting like milling are limited due to their brittle-like failure due to low fracture toughness. In this work, alternative binder systems such as Co-Ni and

Samhällsutmaningarna har stått högt på dagordningen för forskning och innovation i Norden sedan Lunddeklarationen 20091. De sociotekniska systemen som ger oss energi, mat, hälsa och mobilitet, är inte hållbara. Motiveringen till att använda offentliga medel för forskning och innovation förändras i enlighet med detta. Forskning- och innovationspolitik motiveras inte längre enbart av forskningens eg

Stödgrupper för barn som växer upp i familjer med psykisk ohälsa, skadligt bruk/beroende eller våld är en insats som erbjuds av socialtjänsten i många kommuner. Trots att stödgrupper ges på frivilliga grunder utan biståndsprövning, dvs ”lätt tillgängligt” (Prop.2024/25:89), är rekryteringen av barn en utmaning. Denna licentiatuppsats fördjupar kunskapen om de förhållanden och överväganden som påveIn Sweden, preventive support groups for children exposed to domestic violence, substance abuse or mental illness in the home are provided by child welfare services (CWS). Support groups for children are often accessible without assessment, available for families to access at their own request, without formal referral or opening a case file which is assumed to lower the threshold. A current approa

HIV drug resistance (HIVDR) presents a significant challenge to antiretroviral therapy (ART) success, particularly in resource-limited settings like Ethiopia. This cross-sectional study investigated viral suppression rates and resistance patterns among patients on second-line ART across 28 Ethiopian health facilities. Blood samples collected from 586 participants were analyzed to measure CD4 count

Character displacement theory predicts that closely-related co-occurring species should diverge in relevant traits to reduce costly interspecific interactions such as competition or hybridization. While many studies document character shifts in sympatry, few provide corresponding evidence that these shifts are driven by the costs of co-occurrence. Black-capped (Poecile atricapillus) and mountain c

A new focal plane detector system for the Berkeley Gas-filled Separator (BGS) was designed, constructed, and tested offline with various -decay and conversion-electron sources. The SuperHeavy RECoils (SHREC) detector comprises sets of double-sided silicon strip detectors arranged in an open-faced cuboid geometry. Alongside the detector upgrade new digital data acquisition electronics have been com

Buy Now, Pay Later loans (BNPL) are an increasingly popular way to finance small-ticket purchases. We provide new evidence on how BNPL influences regular bank credit markets, benefiting both lenders and borrowers through information production and learning. Using data from over one million unsecured bank loan applications from a bank that also provides BNPL services, we exploit the fact that BNPL enh

We study the coherent photoproduction of light vector mesons in Pb-Pb collisions in the framework of color dipole approach. We employ the Glauber–Gribov formalism supplemented by an effective suppression factor RG accounting for the gluon shadowing correction. We adjust the latter to reproduce the deep inelastic structure function F2 (E665) and ρ meson photoproduction (ALICE) data. We achieve a go

Background: There is a lack of studies on sarcoidosis among immigrants, which is of interest as there may be genetic and environmental characteristics affecting immigrants from certain countries. We aimed to study hazard ratios (HRs) of sarcoidosis in first- and second-generation immigrants, comparing them with native Swedes in the total adult Swedish population. Methods: We conducted a nationwide