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Spekulativa avslöjanden om syfilis. Recension av Agneta Rahikainen : Smittans rike. Om syfilis i konst, kultur och vetenskap
Demokratin sägs vara i svår kris. Recension av Anders Burman: Dissensus. Drömmar och mardrömmar i demokratins idéhistoria och Sofia Näsström: Demokrati. En liten bok om en stor sak
On the importance of audio material in spoken linguistics : A case study of the London–Lund Corpus 2
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Distinct Conformations, Aggregation and Cellular Internalization of Different Tau Strains
The inter-cellular propagation of tau aggregates in several neurodegenerative diseases involves, in part, recurring cycles of extracellular tau uptake, initiation of endogenous tau aggregation, and extracellular release of at least part of this protein complex. However, human brain tau extracts from diverse tauopathies exhibit variant or “strain” specificity in inducing inter-cellular propagation
Human stem cell‐derived gabaergic interneurons establish efferent synapses onto host neurons in rat epileptic hippocampus and inhibit spontaneous recurrent seizures
Epilepsy is a complex disorder affecting the central nervous system and is characterised by spontaneously recurring seizures (SRSs). Epileptic patients undergo symptomatic pharmacolog-ical treatments, however, in 30% of cases, they are ineffective, mostly in patients with temporal lobe epilepsy. Therefore, there is a need for developing novel treatment strategies. Transplantation of cells releasin
Parents’ experiences of weighted blankets’ impact on children with attention-deficit/hyperactivity disorder (ADHD) and sleep problems—A qualitative study
Sleep disturbances are common among children with attention-deficit/hyperactivity disorder (ADHD). While pharmacological treatment has increased dramatically, parents often prefer non-pharmacological interventions. Research on experiences of weighted blankets and their effect in sleep improvement is scarce. The aim of this study was to explore parents’ experiences of weighted blankets for children
Genetic Variant Score and Arrhythmogenic Right Ventricular Cardiomyopathy Phenotype in Plakophilin-2 Mutation Carriers
Introduction: Whether detailed genetic information contributes to risk stratification of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) remains uncertain. Pathogenic genetic variants in some genes seem to carry a higher risk for arrhythmia and earlier disease onset than others, but comparisons between variants in the same gene have not been done. Combined Annotation Dependent
Reprogramming human adult fibroblasts into GABAergic interneurons
Direct reprogramming is an appealing strategy to generate neurons from a somatic cell by forced expression of transcription factors. The generated neurons can be used for both cell replacement strategies and disease modelling. Using this technique, previous studies have shown that γ-aminobutyric acid (GABA) expressing interneurons can be generated from different cell sources, such as glia cells or
The role of water in the reversibility of thermal denaturation of lysozyme in solid and liquid states
Although unfolding of protein in the liquid state is relatively well studied, its mechanisms in the solid state, are much less understood. We evaluated the reversibility of thermal unfolding of lysozyme with respect to the water content using a combination of thermodynamic and structural techniques such as differential scanning calorimetry, synchrotron small and wide-angle X-ray scattering (SWAXS)
StringSpinner - adding spin to the PYTHIA string fragmentation
StringSpinner is a plugin allowing for the introduction of spin effects in the hadronization part of the PYTHIA 8 event generator. In this first version the implementation is limited to handling pesudoscalar mesons in events without parton showers. The spin effects are generated by propagating the quark polarization along the fragmentation chain according to the rules of the quantum mechanical str
Insights on Genetic and Environmental Factors in Parkinson's Disease from a Regional Swedish Case-Control Cohort
BACKGROUND: Risk factors for Parkinson's disease (PD) can be more or less relevant to a population due to population-specific genetic architecture, local lifestyle habits, and environmental exposures. Therefore, it is essential to study PD at a local, regional, and continental scale in order to increase the knowledge on disease etiology.OBJECTIVE: We aimed to investigate the contribution of geneti
Nanoscale structural and mechanical characterization of thin bicontinuous cubic phase lipid films
The mechanical response of lipid membranes to nanoscale deformations is of fundamental importance for understanding how these interfaces behave in multiple biological processes; in particular, the nanoscale mechanics of non-lamellar membranes represents a largely unexplored research field. Among these mesophases, inverse bicontinuous cubic phase QII membranes have been found to spontaneously occur
Don’t blame it on the sunshine! An exploration of the spatial distribution of heat injustice across districts in Antwerp, Belgium
Cities experience temperature differences during heat events, in part modulated by green spaces. In the face of climate change, vegetation and green infrastructure are increasingly important for residents’ thermal comfort. Generally, socio-economically marginalised communities are more likely to live in neighbourhoods with less access to green spaces, which can lead to the experience of hotter tem
Daphnia magna trade-off safety from UV radiation for food
Research on diel vertical migration (DVM) is generally conducted at the population level, whereas few studies have focused on how individual animals behaviorally respond to threats when also having access to foraging opportunities. We utilized a 3D tracking platform to record the swimming behavior of Daphnia magna exposed to ultraviolet radiation (UVR) in the presence or absence of a food patch. W
Danmarks nederlag 1864
Pathways of precipitation formation in different thermodynamic and aerosol environments over the Indian Peninsula
This study examines precipitation pathways in different thermodynamic and aerosol environments over the Indian peninsula. A three-dimensional idealized Large-Eddy Simulation (LES) model with spectral bin microphysics is used to simulate convective clouds growing under different monsoon environments. Numerical simulations were evaluated using in-situ measurements from the Cloud-Aerosol Interactions
Evaluation of polytyramine film and 6-mercaptohexanol self-assembled monolayers as the immobilization layers for a capacitive dna sensor chip : A comparison
The performance of a biosensor is associated with the properties of an immobilization layer on a sensor chip. In this study, gold sensor chips were modified with two different immobilization layers, polytyramine film and 6-mercaptohexanol self-assembled monolayer. The physical, electrochemical and analytical properties of polytyramine film and mercaptohexanol self-assembled monolayer modified gold
Sense of coherence and coping behaviours in persons with late effects of polio
Background: Sense of coherence (SOC), comprising “comprehensibility”, “manageability” and “meaningfulness”, is important for successful adaptation in persons with late effects of polio (LEoP) and can be used as an estimate of the ability to cope with stressors. Coping behaviours are the actions a person performs to reduce stress and can be divided into problem-focused coping, emotion-focused copin