Initiation of adaptive immunity to particulate antigens in lymph nodes largely depends on their presentation by migratory dendritic cells (DCs). DC subsets differ in their capacity to induce specific types of immunity, allowing subset-specific DC-targeting to influence vaccination and therapy outcomes. Faithful drug design, however, requires exact understanding of subset-specific versus global act

Wet eldercare facilities constitute a type of harm reduction arrangements where goals of abstinence are abandoned in favour of goals of increased wellbeing for older people with long-term substance use disorder. The fact that residents are acknowledged as being active in their substance use results in challenges; harmful activities are witnessed by the staff in a context that has actually been cre

Thirty-seven sera positive for anti-GBM antibodies (antibodies against the ‘Goodpasture antigen’ = NCI-domain of collagen IV) in routine analysis were studied for antigen restriction and IgG subclasses. Four different polypeptides, the four α-chains (α1, α2, α3 and α4) of human collagen IV NCI, were used as coating in ELISA assays. Autoantibodies were detected with monoclonal antibodies towards hu

Sera that had been positive in routine ELISA for ANCA were studied retrospectively for the IgG subclass distribution of these autoantibodies. An ELISA previously developed for measurement of IgG sub classes of anti-GBM antibodies was modified for this purpose. Of a total of 247 sera, 114 were found to be positive in at least one of the assays for IgG subclasses of anti proteinase 3, 72 of these pa

One way to analyze the twists and turns in Swedish history politics regarding the Second World War and its legacy is to turn to a typol-ogy of uses of history. Despite differences in occupations, places, and times, uses of history are often joined together by certainneeds and functions that certain choices of history can provide. In this pa-per, I discuss how the images of the Second World War and

OBJECTIVES: We investigated whether a moderate-to-vigorous physical activity (MVPA) level and walking time were associated with a hilly environment in rural Japanese older adults. DESIGN: Cross-sectional study. SETTING: Unnan city, Ohnan and Okinoshima towns in Shimane, Japan. PARTICIPANTS: Data were collected from 1115 adults from the Shimane CoHRE study, who were aged 60 years and older and livi

Objective: Morbidity and mortality due to heart failure (HF) as a complication of myocardial infarction (MI) is high, and remains among the leading causes of death and hospitalisation. This study investigated the association between family history of MI with or without HF, and the risk of developing HF after first MI. Methods: Through nationwide registries, we identified all individuals aged 18-50

The reactive behavior of three catalysts based on Pd-loaded LaFeO3 was investigated in terms of the reducibility of Pd and its propensity to leaching into the liquid phase in flowing solutions prototypical of C-C coupling catalysis in a continuous flow reactor cell. In situ quick extended X-ray absorption fine structure spectroscopy showed that Pd remains stable and nonreducible in the flowing eth

Diets rich in flavonoids have been related with low obesity rates, which could be related with their potential to inhibit pancreatic lipase, the main enzyme of fat assimilation. Some flavonoids can aggregate in aqueous medium suggesting that the inhibition mechanism could occur on both molecular and colloidal levels. This study investigates the interaction of two flavonoid aggregates, quercetin an

Cluster policies are widely used to strengthen regional competitiveness, yet difficult to evaluate. While academic approaches to cluster evaluation are often ignorant of the needs of policy-makers and practitioners, practitioner-led approaches often lack structure and rigour. As such, there remain significant gaps between theory and practice. The contribution of this paper is to reflect on a uniqu

The “Woody” or “Wooden” breast disease is a severe myopathy of pectoralis major muscle recently identified within rapidly growing broiler lines all around the world with a prevalence rate around 20%, or even higher. Although of significant ethical and economic impact, little is known regarding the structural and functional aspects of the contractile apparatus in the woody breast muscle. The aim of

In this paper we present an outline of a research project that will be carried out in 2019 – 2021. Below we give a short summary of the project. SummaryThe flood of #metoo witness narratives has demonstrated the pervasiveness of sexual abuse. Yet, #metoo has also made visible different understandings of justice. The campaign against sexual harassment and violence has brought to the fore tensions b

The spatial distribution of catches of male European pine sawfly, Neodiprion sertifer (Geoffr.) (Hymenoptera, Diprionidae), was studied using different pheromone trap arrays. In hexagonal trap groups, trap interference was evident by reduced catch in the central of seven traps spaced 10 to 40 m apart. When the trap spacings were either 5 or 80 m no significant reduction could be shown. The interac

Mechanical changes within cells and viruses have been shown to be of great importance for various mechano-signaling processes. In phage and herpesviruses, strong confinement of double-stranded DNA inside the capsid generates tens of atmospheres of pressure. This confinement leads to electrostatic sliding friction between neighboring DNA strands. This affects the mobility of the encapsidated genome

The number of children who were born after their parents were diagnosed with central nervous system (CNS) tumor is increasing, but it remains largely unknown regarding the academic performance of these children. We aimed to investigate whether children of survivors with childhood or adolescent CNS tumor were associated with poor academic performance. Children of survivors of CNS tumor were identif