3D-Printed Lung-on-a-chip Device for Monitoring of YAP/TAZ Translocation in Murine Lung Epithelial Cells Under Static and Dynamic Conditions
Here a lung-on-a-chip device was developed and fabricated using 3D-printing of molds. The lung-on-a-chip device was used as a lung injury model by overstretching of murine lung epithelial cells (MLE-12) monolayers, resembling the injury during mechanical ventilation. The cells were exposed to 25% strain, representing pathological conditions seen in ventilator induced lung injury of patients with
