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Neurotrophic factors are secreted proteins responsible for migration, growth and survival of neurons during development, and for maintenance and plasticity of adult neurons. Here we present a novel secreted protein named Cometin which together with Meteorin defines a new evolutionary conserved protein family. During early mouse development, Cometin is found exclusively in the floor plate and from

The gamma evaluation method has become the gold standard for the comparison between measured and calculated absorbed dose distributions. However, test criteria and failure rate tolerance levels have hitherto normally been based on empirical evidence, rather than rigorous statistical analysis. In this work, it is proposed that the gamma-evaluation method could be reinterpreted such that the absorbe

The polyamines are important for a variety of cellular functions, including cell growth. Their intracellular concentrations are controlled by a complex network of regulatory mechanisms, in which antizyme (Az) has a key role. Az reduces the cellular polyamine content by down-regulating both the enzyme catalysing polyamine biosynthesis, ornithine decarboxylase (ODC), and the uptake of polyamines. Th

90 species of Euplectrus are treated: 55 newly described, all from Area de Conservación Guanacaste (ACG),and 35 previously described species, of which 20 occur in ACG. Three of the previously described species(E. brasiliensis Ashmead, E. hircinus (Say), E. ronnai (Brèthes)) have unknown status, owing to missing or severely damaged type material. The new species, all authored by C. Hansson, are: Eu

The aim of this study was to investigate if preoperative measurements of the femoral valgus angle (FVA) affected the mechanical alignment, individual component positions and clinical outcome in total knee arthroplasty (TKA).

Objective: To investigate whether somatosensory impairments are more common in individuals with post-stroke shoulder pain than in those without post-stroke shoulder pain and healthy controls. Design: Descriptive analysis of a convenience sample. Participants: Forty-nine individuals with stroke, 24 with and 25 without post-stroke shoulder pain (median age 65 years), and 11 age- and sex-matched heal

A trial was undertaken to investigate how exposure to graded hypercapnia affected the growth performance of juvenile (15-80g) Atlantic cod. Juveniles were grown at 20‰ salinity and 10°C for 55 days under three hypercapnic regimes: low (2±0.9mgL(-1) CO(2), 0.6mm Hg, 1000μatm), medium (8±0.5mgL(-1) CO(2), 2.8mm Hg, 3800μatm) and high CO(2) exposure (18±0.2mgL(-1) CO(2), 6.3mm Hg, 8500μatm). All wate

The aim of this study was to explore whether islet cell antibodies (ICA) could be identified in children with newly onset diabetes mellitus but negative for autoantibodies against glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A), insulin (IAA), or any of the three variants with arginine (R), tryptophan (W), or glutamine (Q) at position 325 of the zinc transporter 8 (ZnT8A).

A better understanding of why medication errors (MEs) occur will mean that we can work proactively to minimise them. This study developed a proactive tool to identify general failure types (GFTs)in the process of managing cytotoxic drugs in healthcare. The tool is based on Reason’s Tripod Delta tool. The GFTs and active failures were identified in 60 cases of MEs reported to the Swedish national a

Cardiovascular disease and renal impairment are common in cirrhotic transplant candidates. We aimed to investigate potential association between pretransplant renal function impairment and cardiac events after liver transplantation.

Time-frequency representation algorithms such as spectrograms have proven to be useful tools in marine biosonar signal analysis. Although there are several different time-frequency representation algorithms designed for different types of signals with various characteristics, it is unclear which algorithms that are best suited for transient signals, like the echolocation signals of echolocating wh

The purpose of this study was to describe child health centre (CHC) nurses' views of managing parental groups during early childhood. All 311 CHC nurses working within the Swedish CHC system in one county were asked to complete a web-based questionnaire. Findings showed that although the CHC nurses were experienced, several found group leadership challenging and difficult. The need for specialized

Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) pop

The yeast Dekkera/Brettanomyces bruxellensis can cause enormous economic losses in wine industry due to production of phenolic off-flavor compounds. D. bruxellensis is a distant relative of baker's yeast Saccharomyces cerevisiae. Nevertheless, these two yeasts are often found in the same habitats and share several food-related traits, such as production of high ethanol levels and ability to grow w

We study photoionization of argon atoms excited by attosecond pulses using an interferometric measurement technique. We measure the difference in time delays between electrons emitted from the 3s(2) and from the 3p(6) shell, at different excitation energies ranging from 32 to 42 eV. The determination of photoemission time delays requires taking into account the measurement process, involving the i