Ageing significantly alters the body in different ways, especially our perception and experience of it. In the phenomenological perspective, the human mind and body are intertwined with each other as well as intertwined with the surrounding world; consequently an altered body will affect the experience of both self and the world. This article discuss how and when ageing and old age affect the expe

B cell homeostasis is regulated by multiple signaling processes, including nuclear factor-kappaB (NF-kappaB), BAFF-, and B cell receptor signaling. Conditional disruption of genes involved in these pathways has shed light on the mechanisms governing signaling from the cell surface to the nucleus. We describe a novel mouse strain that expresses solely and excessively a naturally occurring splice va

Dementia diagnosis is important for many different reasons. Firstly, to separate dementia, or major neurocognitive disorder, from MCI (mild cognitive impairment), mild neurocognitive disorder. Secondly, to define the specific underlying brain disorder to aid treatment, prognosis and decisions regarding care needs and assistance. The diagnostic method of dementias is a puzzle of different data piec

In recent years there has been an increased interest in the function of inhibitory interneurons. In the cerebellum this interest has been paired with successes in obtaining recordings from these neurons in vivo and genetic manipulations to probe their function during behavioral tasks such as motor learning. This review focuses on a synthesis of recent findings on the computational properties that

Background. The invasive disease potential (IDP) of Streptococcus pneumoniae differs between serotypes, but the reason for this is unknown. Methods. A total of 47 pneumococcal isolates from 13 serotypes with different IDPs in humans that belonged to 37 multilocus sequence types were compared by whole genome microarrays and mutant analyses. Results. Approximately 34% of the genes were variable, inc

The growth-promoting polyamines are polybasic compounds that efficiently enter cancer cells by as yet incompletely defined mechanisms. Strategies to inhibit their internalization may have important implications in the management of tumor disease. Here, we show that cellular binding and uptake of polyamines are inhibited by a single chain variable fragment anti-heparan sulfate (HS) antibody. Polyam

The life chart offers rich information that provides a broader picture of the lives of women who have experienced abuse. Life charts could be useful for nurses identifying women in general psychiatric care who have experienced abuse. Despite experiences of abuse and stressful events during childhood, there were only a few indications of them receiving support in the life charts. Many of the women

We use simulations to investigate the effect of sampling frequency on common dependent variables in eye-tracking. We identify two large groups of measures that behave differently, but consistently. The effect of sampling frequency on these two groups of measures are explored and simulations are performed to estimate how much data are required to overcome the uncertainty of a limited sampling frequ

Study Design. Descriptive register studyObjective. To describe preoperative levels of leg and back pain in patients operated for lumbar spinal stenosis and to obtain information on how three different pain constellations (back pain < leg leg pain, back pain > leg pain, back pain = leg pain) correlate to HRQoL and function in different morphological types of stenosis.Summary of Background Data. Deg