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Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption
The aim of this work is to investigate the improvement of image quality in few-view grating-based phase-contrast computed tomography (PCCT) applications via compressed sensing (CS) inspired iterative reconstruction on an in vitro mouse model. PCCT measurements are performed on a grating-based PCCT setup using a high-brilliance synchrotron source and a conventional tube source. The sampling density
X-ray grating interferometry is a coherent imaging technique that bears tremendous potential for three-dimensional tomographic imaging of soft biological tissue and other specimens whose details exhibit very weak absorption contrast. It is intrinsically trimodal, delivering phase contrast, absorption contrast, and scattering ("dark-field") contrast. Recently reported acquisition strategies for gra
After successful demonstrations of soft-tissue phase-contrast imaging with grating interferometers at synchrotron radiation sources and at laboratory based x-ray tubes, a first preclinical CT scanner with grating based phase contrast imaging modality has been constructed. The rotating gantry is equipped with a three-grating interferometer, a 50 watt tungsten anode source and a Hamamatsu flat panel
X-ray phase and dark-field contrast have recently been the source of much attention in the field of X-ray imaging, as they both contribute new imaging signals based on physical principles that differ from conventional X-ray imaging. With a so-called Talbot grating interferometer, both phase-contrast and dark-field images are obtained simultaneously with the conventional attenuation-based X-ray ima
Purpose: One of the main limitations of absorption‐based x‐ray imaging of biomedical specimen is the weak soft‐tissue contrast. This limitation can be addressed by phase‐sensitive imaging methods facilitating considerably improved density resolution. During the last decades various approaches have been investigated ‐ amongst them grating‐based interferometric methods with laboratory x‐ray sources.
This is presentation of a research project that investigates the learning and teaching of Swedish folk music as it unfolds across different contexts of transmission. Studies have shown that spaces for the transmission of Swedish folk music involves many aspects of social life (von Wachenfeldt, 2015, Eriksson, 2017, Eriksson, 2019). At the same time other pragmatic factors frame the transmission ta
The aim of this doctoral dissertation is to explore and describe the relationship and interaction between musicians and their instruments. In order to achieve a high level of detail, a certain instrument is in focus: the simple-system flute. Although primarily developed as a product of 19th- century Western art music, this instrument has since become established in other genres and traditions. Emp
Background: Physical activity (PA) may improve work ability and health in individuals with hip and/or knee osteoarthritis (OA). The use of wearable activity trackers (WATs) has been shown to increase PA and improve other health outcomes but little is known concerning their effect on work ability. The objectives of this study were to examine the effect of self-monitoring PA with a WAT on work abili
OBJECTIVE: To explore how persons who have returned to work perceive their work situation and work ability one year after stroke. DESIGN: Cross-sectional design. SUBJECTS: A total of 88 persons of working age (mean age 52 (standard deviation; SD 8) years, 36% women), with mild to moderate disabilities following stroke, who had returned to work within one year after stroke participated in the study
Sepsis is defined as a life-threatening condition caused by a dysregulated host response to infection. Neutrophils are themost abundant innate immune cells of the body and play a key role in septic pathogenesis. During sepsis activatedneutrophils release web-like traps decorated with various cellular proteins known as neutrophil extracellular traps(NET). The primary task of NET and NET-associated
Introduction There is controversy regarding the importance of air-transmitted infections for surgical site infections (SSIs) after orthopaedic surgery. Research has been hindered by both the inability in blinding the exposure, and by the need for recruiting large enough cohorts. The aim of this study is to investigate whether using a new form of air purifier using plasma air purification (PAP) in
Background: The response to neoadjuvant cisplatin-based chemotherapy (NAC) in muscle-invasive bladder cancer (MIBC) is impaired in up to 50% of patients due to chemoresistance, with no predictive biomarkers in clinical use. The proto-oncogene RNA-binding motif protein 3 (RBM3) has emerged as a putative modulator of chemotherapy response in several solid tumours but has a hitherto unrecognized role
ObjectivesIn Phase 1 of developing new hand osteoarthritis (OA) classification criteria, features associated with hand OA were identified in a population with hand complaints. Radiographic findings could better discriminate patients with hand OA and controls than clinical examination findings. The objective of Phase 2 was to achieve consensus on the features and their weights to be included in thr
Worldwide, racial and ethnic minorities have been disproportionately impacted by COVID-19 with increased risk of infection, its related complications, and death. In the initial phase of population-based vaccination in the United States (U.S.) and United Kingdom (U.K.), vaccine hesitancy may result in differences in uptake. We performed a cohort study among U.S. and U.K. participants who volunteere
Let M be a compact, connected C∞ manifold with a C∞ Riemannian metric or let M=Rn with Euclidean metric. Let g denote the metric. On M consider the 2×2 system of Schrödinger operators[TeX:] \[P=-h^{2}\Delta +V+h^{2}\mathcal{W},\qquadV=\left(\begin{array}[cc]v_{1}&0\\0&v_{2}\end{array}\right)\]where v1,v2∈C∞(M) are non-negative, and W is a C∞, first order formally selfadjoint differential o
Severe obesity in adolescence profoundly impacts health and social well-being. Lifestyle modifications are seldom successful in maintaining sufficient weight loss to mitigate the risk of complications. Metabolic and bariatric surgery (MBS) is a standard treatment for adult patients and has emerged as an option for adolescent patients. Several high-quality studies of adolescent MBS show substantial
Optimization based on traditional forward motion analysis to ensure a prescribed load distribution on a deformed geometry is challenging, since the load distribution is highly coupled to the deformed geometry, boundary conditions, and the optimized material layout. In contrast to traditional forward motion analysis, the deformed configuration is prescribed in the inverse motion analysis, and the u
