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Breast cancer survival in the US and Europe: a CONCORD high-resolution study

Breast cancer survival is reportedly higher in the US than in Europe. The first worldwide study (CONCORD) found wide international differences in age-standardized survival. The aim of this study is to explain these survival differences. Population-based data on stage at diagnosis, diagnostic procedures, treatment and follow-up were collected for about 20,000 women diagnosed with breast cancer aged

Identity undoing and power relations in leadership development

Leadership development theory and practice is increasingly turning its gaze on identity as a primary focus for development efforts. Most of this literature focuses on how the identities of participants are strengthened, repaired and evolved. This article focuses on identity work practices that are underdeveloped in the literature: the deconstruction, unravelling and letting go that can be experien

First multi-bend achromat lattice consideration.

By the beginning of 1990, three third-generation synchrotron light sources had been successfully commissioned in Grenoble, Berkeley and Trieste (ESRF, ALS and ELETTRA). Each of these new machines reached their target specifications without any significant problems. In parallel, already at that time discussions were underway regarding the next generation, the `diffraction-limited light source (DLSR

The importance of socioeconomic factors for compliance and outcome at screening for abdominal aortic aneurysm in 65-year-old men.

OBJECTIVE: To evaluate compliance with screening and prevalence of abdominal aortic aneurysm (AAA) in relation to background data regarding area-based socioeconomic status. METHODS: Our department annually invites 4300 65-year-old men from the city of Malmö and 15 neighboring municipalities to ultrasound AAA screening. In a cross-sectional cohort study, compliance and AAA prevalence among 8269 men

Progress in Developing a Low-Cost Large Deformable Mirror

Large (> 1m) deformable mirrors with hundreds or thousands of actuators are attractive for extremely large telescopes. Use of force actuators coupled to the mirror via suction cups, and electret microphones for position sensing, has the potential of substantially reducing costs. However, a mirror controlled with force actuators will have many structural resonances within the desired system bandwid

Howard's algorithm in a phase-field topology optimization approach

Abstract in UndeterminedThe topology optimization problem is formulated in a phase-field approach. The solution procedure is based on the Allan–Cahn diffusion model where the conservation of volume is enforced by a global constraint. The functional defining the minimization problem is selected such that no penalization is imposed for full and void materials. Upper and lower bounds of the density f

Climatic variability during the last interglacial inferred from geochemical proxies in the Lake El'gygytgyn sediment record

The Last Interglacial Period (LIP) is often regarded as a good analogue for potential climatic conditions under predicted global warming scenarios. Despite this, there is still debate over the nature, duration and frequency of climatic changes during this period. One particularly contentious issue has been the apparent evidence of climatic instability identified in many marine cores but seemingly

Decreased cord-blood phospholipids in young age at onset type 1 diabetes.

Children developing type 1 diabetes may have risk markers already in their umbilical cord blood. It is hypothesized that the risk for type 1 diabetes at an early age may be increased by a pathogenic pregnancy and be reflected in altered cord-blood composition. In this study metabolomics was used to test if the cord-blood lipidome was affected in children diagnosed with type 1 diabetes before eight

Limiting the parameter space in the Carbon Cycle Data Assimilation System (CCDAS)

Terrestrial ecosystem models are employed to calculate the sources and sinks of carbon dioxide between land and atmosphere. These models may be heavily parameterised. Where reliable estimates are unavailable for a parameter, it remains highly uncertain; uncertainty of parameters can substantially contribute to overall model output uncertainty. This paper builds on the work of the terrestrial Carbo

Influence of ion pairing in ionic liquids on electrical double layer structures and surface force using classical density functional approach.

We explore the influence of ion pairing in room temperature ionic liquids confined by planar electrode surfaces. Using a coarse-grained model for the aromatic ionic liquid [C4MIM(+)][BF4 (-)], we account for an ion pairing component as an equilibrium associating species within a classical density functional theory. We investigated the resulting structure of the electrical double layer as well as t

Effect of celecoxib on survival in patients with advanced non-small cell lung cancer: A double blind randomised clinical phase III trial (CYCLUS study) by the Swedish Lung Cancer Study Group

Background: Increased expression of cyclooxygenase-2 (COX-2) is common in non-small cell lung cancer (NSCLC) and has been associated with poor prognosis. Experimental and clinical phase II trials have indicated that the addition of the COX-2 inhibitor celecoxib to palliative chemotherapy might increase survival time in patients with advanced NSCLC. Methods: We performed a double-blind, placebo-con

When Errors Become the Rule : Twenty Years with Transformation-Based Learning

Transformation-based learning (TBL) is a machine learning method for, in particular, sequential classification, invented by Eric Brill [Brill 1993b, 1995a]. It is widely used within computational linguistics and natural language processing, but surprisingly little in other areas. TBL is a simple yet flexible paradigm, which achieves competitive or even state-of-the-art performance in several area

A/H1N1 antibodies and TRIB2 autoantibodies in narcolepsy patients diagnosed in conjunction with the Pandemrix vaccination campaign in Sweden 2009-2010.

Narcolepsy is a lifelong sleep disorder related to hypocretin deficiency resulting from a specific loss of hypocretin-producing neurons in the lateral hypothalamic area. The disease is thought to be autoimmune due to a strong association with HLA-DQB1*06:02. In 2009 the World Health Organization (WHO) declared the H1N1 2009 flu pandemic (A/H1N1PDM09). In response to this, the Swedish vaccination c

'I thought I was the only one': the misrecognition of LGBT youth in contemporary Vietnam.

While recent LGBT rights demonstrations and discussions about same-sex marriage have thrust the issue of homosexuality into the spotlight, it was not long ago that the issue of homosexuality was notable by its absence in Vietnam. Drawing on semi-structured interviews with young gay, lesbian and bisexual people in Vietnam's capital city Hanoi, this paper considers the increasing visibility of homos

Increased long-term mortality with plasma transfusion after coronary artery bypass surgery.

PURPOSE: Patients undergoing cardiac surgery often require transfusions of red blood cells, plasma and platelets. These components differ widely in both indications for use and composition. However, from a statistical point of view there is a significant colinearity between the components. This study explores the relation between the transfusion of different blood components and long-term mortalit