Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training can decelerate, or reverse epigenetic aging in humans is unknown. Here, we performed a powerful meta-analysis of the methylome and transcriptome of an unprecedented number of h

Rising global temperatures are creating a variety of changes in polar regions and pushing organisms to new extremes. Snow cover changes in the arctic are leading to exposed soils, allowing the soil to freeze at lower temperatures and experience freeze thaw cycles. In this study, I investigated the effect of freeze thaw cycles on arctic microorganisms, focusing on the main microbial groups bacteria

The human vestibulo-ocular reflex (VOR) leads to maintenance of the acuity of an image on the retina and contributes to the perception of orientation during high acceleration head movements. Our objective was to determine whether vision affects the horizontal VOR by assessing and comparing the performance at the boundaries of contribution of: (a) unrestricted visual information and (b) no visual i

BACKGROUND: Epidemiological research on effects of transportation noise on incident hypertension is inconsistent.OBJECTIVES: We aimed to investigate whether residential road traffic noise increases the risk for hypertension.METHODS: In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling ≥2 p

RATIONALE: Little is known about how perinatal and childhood factors influence lung function change between childhood and adolescence.OBJECTIVES: To investigate possible early life predictors of change in FEV1 between age 8 and 16 years. In addition, to investigate possible predictors of having persistently low lung function (FEV1

Ökning i sydliga lövsångares flyttningsbeteende Fåglars flyttning har länge fascinerat människan och kanske framförallt småfåglars flyttning. Hur kan t. ex. en lövsångare, Phylloscopus trochilus, på 10 gram som föddes för några månader sedan hitta hela vägen ner till övervintringsområdena i Afrika, dessutom helt utan hjälp av andra? Sedan länge är det känt att svaret verkar ligga i deras gener mDifferences in migratory behaviour has long been suggested to potentially drive speciation, but the genetics underlying this process remains a mystery. Studies of hybrid zones between two closely related taxa with contrasting migratory phenotypes, called migratory divides, have played a crucial role for our understanding of how such differences can lead to reproductive isolation. Movements of hybr

In recent decades, studies of Roman domestic space have proliferated. The result is a rich but impenetrable picture, with scholars often favoring the use of ancient sources on one hand and finds from excavated houses or material remains on the other. Studies have emphasized how light can be approached to investigate space and its social meaning. At the same time, in the field of digital technologi

OBJECTIVE: To identify and genetically characterize subgroups of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) based on sex and ANCA subtype.METHODS: A previously established SNP dataset derived from DNA sequencing of 1853 genes and genotyping of 1088 Scandinavian cases with AAV and 1589 controls was stratified for sex and ANCA subtype and analysed for ass

This contribution investigates possible material expressions of hetero- and homoerotic expressions on the holy island of Helgö and close-by Hundhamra from the Late Iron Age (c. 550-1050 CE).

BACKGROUND AND OBJECTIVES: Injured pericytes in the neurovascular unit release platelet-derived growth factor β (PDGFRβ) into the cerebrospinal fluid (CSF). However, it is not clear how pericyte injury contributes to Alzheimer's disease (AD)-related changes and blood brain barrier (BBB) damage. We aimed to test if CSF PDGFRβ was associated with different AD- and age-associated pathological changes