Sökresultat

Background: The global gene regulator Special AT-rich sequence-binding protein1 (SATB1) has been reported to reprogramme tumour cells into a more malignant phenotype and associate with poor clinical outcome in several cancer forms. In this study, we investigated the molecular correlates and prognostic impact of SATB1 expression in human epithelial ovarian cancer (EOC). Findings: Immunohistochemica

Abstract in German Die Parkinson-Krankheit („Parkinson”) ist eine neurodegenerative Erkrankung die durch den Verlust von Dopamin-produzierenden Nervenzellen in der Substantia Nigra und daraus resultierenden, typischen motorischen Symptomen gekennzeichnet ist. Die Standardbehandlung für Parkinson ist die Gabe von L-DOPA, zum Zweck der Ersetzung des verlorengegangen Dopamins. Eine Langzeittherapie mParkinson’s disease (PD) is a neurodegenerative disorder, characterized by the loss of dopamine (DA) producing neurons in the substantia nigra pars compacta (SNc), resulting in typical motor symptoms. DA replacement with L-DOPA is the standard therapy for PD. However, with treatment duration many patients face the severe treatment complication of L-DOPA-induced dyskinesia (LID), constituting in ab

Beliefs in signals that reveal lies and truths are widespread. It is shown that such beliefs may be exploited strategically in signaling games of pure conflict of interest. Truth and lie detection is modeled by signals perceived by the receiver that are emitted with a probability contingent on the truth value of the sender's message. Truth or lie detection of this kind always shrinks the equilibri

Transverse momentum distributions and yields for pi(+/-), K-+/-, p, and (p) over bar in p + p collisions at root s = 200 and 62.4 GeV at midrapidity are measured by the PHENIX experiment at the Relativistic Heavy Ion Collider (RHIC). These data provide important baseline spectra for comparisons with identified particle spectra in heavy ion collisions at RHIC. We present the inverse slope parameter

Conjugated polymer/fullerene-based solar cells are, due to their potential flexibility, cost efficiency and low weight, interesting as future alternatives to today’s silicon cells [1]. In these cells, both the dissociation of the polymer exciton into extractable charges, i.e. charges that are free and mobile, and the recombination of the free charges are expected to be crucial in order to obtain h

Patients with a life-limiting diagnosis of pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) need disease-specific information, ability to cope, and functioning social networks. This cohort study investigated the experiences of PAH and CTEPH patients who received information about their diagnosis, treatment, and management, in addition to coping and soc

Bracon hebetor is a larval ectoparasitoid that utilizes several pests belonging to the family Pyralidae (Lepidoptera) as hosts. In the present study, we analyzed the kairomonal response of this wasp to the male-produced sex pheromone of a host, the greater wax moth Galleria mellonella, an economically important pest of honeybees, Apis mellifera. Coupled gas chromatography-electroantennographic det

Biologically treated wastewater spiked with a mixture of 56 active pharmaceutical ingredients (APIs) was treated with 0-20 mg/L chlorine dioxide (ClO2) solution in laboratory-scale experiments. Wastewater effluents were collected from two wastewater treatment plants in Sweden, one with extended nitrogen removal (low COD) and one without (high COD). About one third of the tested APIs resisted degra

The thermal effects related to wearing headgear are complex and different studies have investigated single parts of this topic. This review aims at summarizing the different findings to give a complete overview on this topic as well as to suggest new perspectives. Headgear increases head insulation and therefore is mainly problematic under warm conditions, which is the focus of this review. Helmet

Background: One-pot multi-step biocatalysis is advantageous over step-by-step synthesis as it reduces the number of process operation units, leading to significant process intensification. Whole-cell biocatalysis with metabolically active cells is especially valuable since all enzymes can be co-expressed in the cell whose metabolism can be exploited for supply of co-substrates and co-factors. Resu

Quantum dots (QDs) and graphene are both promising materials for the development of new-generation optoelectronic devices. Towards this end, synergic assembly of these two building blocks is a key step but remains a challenge. Here, we show a one-step strategy for organizing QDs in a graphene matrix via interfacial self-assembly, leading to the formation of sandwiched hybrid QD-graphene nanofilms.

We found marked improvement of glucose tolerance and lower dietary energy intake in ischemic heart disease (IHD) patients after advice to follow a Paleolithic diet, as compared to a Mediterranean-like diet. We now report findings on subjective ratings of satiety at meals and data on the satiety hormone leptin and the soluble leptin receptor from the same study.

We review some aspects of the investigation of surface systems with soft X-rays. Examples are presented, showing how core level spectroscopies provide detailed information on the structure, bonding and chemistry of adsorbates and thin layers on surfaces. Core level spectroscopies employed at high brilliance synchrotron light sources allow furthermore access to electron dynamics in the attosecond d

Human bone marrow (BM) contains a rare population of nonhematopoietic mesenchymal stromal cells (MSCs), which are of central importance for the hematopoietic microenvironment. However, the precise phenotypic definition of these cells in adult BM has not yet been reported. In this study, we show that low/negative expression of CD140a (PDGFR-α) on lin(-)/CD45(-)/CD271(+) BM cells identified a cell p

Inom ramen för det svenska forskningsprojektet Taktik och metodik vid brand i undermarksanläggningar har ett enkelt planeringsverktyg utvecklats som bl a erbjuder stöd till beslutsfattare involverade i planeringen av räddningsinsatser i väg- och järnvägstunnlar. Verktyget, som har utvecklats vid Lunds universitet, heter TuFT och är en förkortning av Tunnel Fire Tools. TuFT kan beskrivas som ett myWithin the Swedish research project Rescue tactics and methodology during fires in underground facilities, a simple decision support tool has been developed. The tool can, for example, aid decision makers involved in the early phase of road and rail tunnel fire risk assessments. The tool has been developed at Lund University and has been termed TuFT, which is an abbreviation for Tunnel Fire Tools.