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Periprosthetic Joint Infections. Clinical and Epidemiological Aspects.

Periprostheteic joint infection (PJI) is a rare complication of arthroplasty with severe consequences for the affected patients. PJI most often necessitates additional surgery and prolonged courses of antibiotic treatment, leading to worse functional results and increased societal costs. Evaluating treatment of PJI as well as preventive efforts are essential to increase our understanding of PJI an

Optimizing Exposome-wide Assessments in Cardiometabolic Risk

This thesis is focused on cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D), two concomitant conditions that appear with growing concern. In our work, we aim to improve the identification of individuals at-risk of cardiometabolic disease through the characterization of complex environmental exposures (i.e. diet, physical activity), that temporally vary, and the health effects on card

Reduced renal elimination of larger molecules is a strong predictor for mortality

Renal dysfunction is a major risk factor for premature death and has been studied extensively. A new renal syndrome, shrunken pore syndrome (SPS), confers higher mortality in all studied populations. SPS is a condition in which cystatin C-based estimation of glomerular filtration rate (eGFRcystatin C) is ≥ 60% than creatinine-based estimation of glomerular filtration rate (eGFRcreatinine). We aime

Vid pornografins gräns : Erotik i svensk prosa 1819–2019

Omstridda sexuella representationer har länge varit en konfliktyta i en västerländsk kontext. Vissa av dessa representationer har snabbt avfärdats som obscena, pornografiska, smutsiga, värdelösa eller ointressanta, medan andra har utmanat etablerade kategoriseringar och blivit föremål för intensiv debatt. För att undersöka och förstå de skriftliga sexuella representationernas historia i en svensk Transgressive sexual representations have long been a point of contention in Western societies. While some representations are easily disregarded as obscene, pornographic, smut, worthless or uninteresting, others disrupt established categorizations and are subject to heated debates. To map and understand the history of written, sexual representations in a Swedish context, I use the literature/porn

Enzymatic conversion of β-mannans: Analysing, evaluating and modifying transglycosylation properties of glycoside hydrolases

Retaining glycoside hydrolases are enzymes that catalyse the breakdown down of glycans through hydrolysis. Due to the double-replacement mechanism of the retaining glycoside hydrolases (GHs), which form an intermediate with part of the glycan covalently attached to the enzyme, some GHs are able to catalyse synthesis reactions called transglycosylation. In transglycosylation reactions a hydroxyl-co

Bench to bedside : Mechanisms and consequences of alcohol-altered host defenses

This article presents the proceedings of a symposium presented at the 2004 ISBRA meeting in Mannheim, Germany, October 1, 2004. The organizers and chairpersons were Joseph H. Sisson, MD, and Claudia Spies, MD. The presentations were as follows: "Alcohol: Impact on Mucociliary Clearance"; "Alcohol and Alveolar Epithelial Dysfunction"; "The Reluctant Neutrophil in Lung Bacterial Host Defense During

Folkparkernas roll som politiska samlingsplatser: Reflektioner kring storstrejken 1909

Folkparkerna förstås idag ofta som baser för arbetarrörelsens kulturella projekt. Men allra tydligast under parkrörelsens första tre decennier hade de även en fundamental politiska roll. I denna presentation fokuserar vi på denna roll i ljuset av storstrejken 1909, där parkerna spelade en viktig roll för arbetarrörelsen som tydliga politiska platser på offentlighetens kant. När många andra platser

Novel glycomimetic inhibitors and proteolysis-targeting chimeras for human galectins

Galectins are a family of soluble proteins that bind β-D-galactopyranoside-containing glycoconjugates through their conserved carbohydrate-recognition domains. Galectins have emerged as promising drug targets due to their involvement in various pathological conditions, such as tumor growth and metastasis, autoimmune and inflammatory diseases, as well as metabolic disorders.This first part of the t

Operational Definitions of Treatment Response and Remission in Obsessive-Compulsive Disorder Capture Meaningful Improvements in Everyday Life

Introduction: The operational definitions of treatment response, partial response, and remission in obsessive-compulsive disorder (OCD) are widely used in clinical trials and regular practice. However, the clinimetric sensitivity of these definitions, that is, whether they identify patients that experience meaningful changes in their everyday life, remains unexplored.Objective: The objective was t

Optimal Landfill Site Selection for Solid Waste of Three Municipalities Based on Boolean and Fuzzy Methods: A Case Study in Kermanshah Province, Iran

In recent decades, population increase and urban development have led to catastrophic environmental consequences. One of the principal objectives to achieve “sustainable development” is to find suitable landfills. Due to their physical characteristics, which have led to a lack of landfill sites and closeness to water bodies, agricultural fields, and residential areas, the cities of Javanrood, Pave

In the Name of Energy Efficiency : Justice and energy poverty in the energy transition of Swedish housing

The energy transition of housing is accelerating in parallel with economic inequality reaching historically high levels. There is thus an opportunity to reduce inequalities in living conditions, but also a risk that the costs of the transition are unequally distributed and aggravate existing inequalities. In order to seize the opportunity for a just transition, and in tandem enable a meaningful inThe energy transition of housing is accelerating in parallel with economic inequality reaching historically high levels. There is thus an opportunity to reduce inequalities in living conditions, but also a risk that the costs of the transition are unequally distributed and aggravate existing inequalities. In order to seize the opportunity for a just transition, and in tandem enable a meaningful in