Nanoparticle (NP) mediated drug delivery into viscous biomatrices, e.g., mucus and bacterial biofilms, is challenging. Lipid shell-enveloped polymeric NPs (Lipid@NPs), composed of a polymeric NP core coated with a lipid shell, represent a promising alternative to the current delivery systems. Here, we describe the facile methods to prepare Lipid@NPs with high integrity of lipid shells and demonstr

We evaluated the performance of QuantiFERON-TB Gold Plus (QFT-Plus), which includes two Mycobacterium tuberculosis antigen formulations (TB1 and TB2), for detection of latent tuberculosis infection during pregnancy. Eight-hundred-twenty-nine Ethiopian pregnant women (5.9% HIV-positive) were tested with QFT-Plus, with bacteriological sputum analysis performed for women with clinically suspected tub

Background: Patients with lumbar disc herniation are treated with physiotherapy/medication and some with surgery. However, even after technically successful surgery some develop a failed back syndrome with persistent pain. Our aim was to evaluate the efficacy of epiduroscopy in patients who suffer chronic low back pain and/or radicular pain with or without surgery and the gender difference in outc

This paper is based on a roundtable discussion held in September 2016 as part of the Pedagogical Inspiration Conference for teachers at the Faculties of Humanities and Theology at Lund University (LU). The roundtable was meant to focus specifically on the consequences of the lack of permanent teaching positions for the quality of the pedagogical work carried out at LU. However, as will be discusse

News images have played a defining role in the unfolding narratives of what has become known as the European migration crisis. Throughout the coverage of the crisis, a predominant and enduring image has been of photographs documenting the migrant journey by sea. This paper takes a closer look at these images, as a vehicle which shifts the narrative of the crisis as one defined by a territorial and

Multiple sclerosis is a neuroinflammatory degenerative disease, caused by activated immune cells infiltrating the CNS. The disease etiology involves both genetic and environmental factors. The mouse genetic locus, Eae27, linked to disease development in the experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis, was studied in order to identify contributing disease susceptibi

The present paper argues for more conceptually-laden research on the constitution of place branding as a hybrid form of urban policy. By both drawing from empirical examples and problematizing the extensive research on place branding, this paper offers the view of place branding as an impolitical form of urban policy that emerges as a biopolitical apparatus in an ecology of complex political pract

Recent neuroscientific and technical developments of brain machine interfaces have put increasing demands on neuroinformatic databases and data handling software, especially when managing data in real time from large numbers of neurons. Extrapolating these developments we here set out to construct a scalable software architecture that would enable near-future massive parallel recording, organizati

We present some work in progress based on observations of the use of version Control systems in two different software development organizations. We consider the emergent user experience, and analyze the structure of the conceptual model and its presentation to see how this experience is formed. We consider its impact on the adoption of such tools outside software engineering and suggest future li

Background: The patient’s view of their mental health is a central aspect in research and practice. Yet, little is known about which psychopathological symptoms are linked with patients’ satisfaction with their mental health. We aimed to identify these symptoms in patients with schizophrenia. Methods: An individual patient data meta-analysis was conducted with data from 2,488 patients from 8 indep

We introduce an adaptive algorithm for sampling multivariate diffusion bridges that performs well for both diffusion and drift dominated models.The algorithm combines the residual bridge sampler with adaptive MCMC, allowing the algorithm to make online improvements upon the ordinary residual bridge algorithm.The simulation study show that the proposed bridge sampler is performing at least as good

Zambia, previously Northern Rhodesia, has exhibited a remarkable consistencyin the focus of its agricultural policies throughout the colonial and independenceeras. Assessing the 100 year period from 1915, this study applies a political economy framework to present evidence on the extent to which, and throughwhat mechanisms, initial natural resource endowments have influenced statepolicies in Zambi

Background: To describe the uptake and system-level effects of the introduction of biosimilars in a setting without forced switching. Research design and methods: We used data from the Swedish Rheumatology Quality register from start of marketing of infliximab (Remsima® and Inflectra®) and etanercept (Benepali®) biosimilars until 31 December 2016. We compared users of each originator-product and i

Background/Aim: Treatment of latently infected individuals at increased risk of reactivation is a cornerstone in tuberculosis control. Although asylum seekers without residence permit in Sweden are offered screening for both active tuberculosis and latent tuberculosis infection (LTBI), treatment for LTBI is often not initiated due to anticipated low rates of treatment completion. We aimed to compa