The Japanese drug company Astellas has had its knuckles rapped for wrongdoing four times in less than three years. Now Deborah Cohen, Shai Mulinari, and Piotr Ozieranski reveal fresh claims about the treatment of an employee who offered to help it clean up its act

Background: Informed consent is a prerequisite for patients included in clinical trials. Trial design, inclusion criteria and legal requirements are increasingly complex. This complexity challenges design and delivery of written and oral trial information to ensure understandable information. To evaluate the level of concordance between patients' and informing physicians' assessments regarding pat

Background: There have been many successful strategies to implement xylose metabolism in Saccharomyces cerevisiae, but no effort has so far enabled xylose utilization at rates comparable to that of glucose (the preferred sugar of this yeast). Many studies have pointed towards the engineered yeast not sensing that xylose is a fermentable carbon source despite growing and fermenting on it, which is

Background: Optimal infusion rate of colloids in patients with suspected hypovolemia is unknown, and the primary objective of the present study was to test if plasma volume expansion by 5% albumin is greater if fluid is administered slowly rather than rapidly. Methods: Patients with signs of hypoperfusion after major abdominal surgery were randomized to intravenous infusion of 5% albumin at a dose

OBJECTIVE Gastrointestinal adverse effects occur in 20–30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5–10% of the cases. Gastrointestinal intolerance may reflect localized high concentrations of metformin in the gut. We hypothesized that reduced transport of metformin via the plasma membrane monoamine transporter (PMAT) and organic cation transport

We describe a computational imaging system for x-ray tomography, where image capture and post-processing are co-designed to improve final image quality when relative motion of an experiment’s components during a single exposure causes motion blur. The idea is based on temporally encoding the motion during each exposure by fluttering the detector shutter open and closed with a known sequence for gu

Swan bands-characteristic molecular absorption features of the C2 molecule-are a spectroscopic signature of carbon-enhanced stars. They can also be used to identify carbonenhanced metal-poor (CEMP) stars. The GALAH (GALactic Archaeology with Hermes) is a magnitude-limited survey of stars producing high-resolution, high-signal-to-noise spectra. We used 627 708 GALAH spectra to search for carbon-enh

Background: Sportsman's hernia/athletic pubalgia is a recognized cause of chronic groin pain in athletes. Both open and laparoscopic surgical repairs have been described for treatment, but there are no comparative studies. The hypothesis here was that relief of pain would be achieved earlier in patients treated with open minimal suture repair than totally extraperitoneal repair. Methods: A randomi

Fire evacuations at wildland-urban interfaces (WUI) pose a serious challenge to the emergency services, and are a global issue affecting thousands of communities around the world. This paper presents a multi-physics framework for the simulation of evacuation in WUI wildfire incidents, including three main modelling layers: wildfire, pedestrians, and traffic. Currently, these layers have been mostl

Denna femte studie behandlar Supply chain information sharing (SCIS), d.v.s. hur företag delar information i försörjningskedjan. Vi försöker också förstå hur företag delar information i försörjningskedjan - både mellan företagets interna avdelningar/funktioner och med viktiga partners. Analysen bygger på svar från 34 panelmedlemmar.

Background: Family risks for urinary tract cancers (excluding kidney cancers) are known, but less is known about whether rare urinary tract cancer subtypes are also familial and if urinary tract cancers share familial risk for other (discordant) cancers. Objective: To investigate the impact of family history on urinary tract cancers (International Classification of Diseases version 7 code 181) and

The discovery of collectivity in proton–proton collisions, is one of the most puzzling outcomes from the first two runs at LHC, as it points to the possibility of creation of a Quark–Gluon Plasma, earlier believed to only be created in heavy ion collisions. One key observation from heavy ion collisions is still not observed in proton–proton, namely jet-quenching. In this letter it is shown how a m

Background: Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors. Methods: This larges