The existing information supports the use of this material as described in this safety assessment. 1-(2-Methylprop-2-enoloxy)-2,2,4-trimethylpentan-3-ol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 1-(2-methylprop-2-enoloxy)-2,2,4-trimethylpen

Survival for patients diagnosed with mantle cell lymphoma (MCL) has improved drastically in recent years. However, patients carrying mutations in tumour protein p53 (TP53) do not benefit from modern chemotherapy-based treatments and have poor prognosis. Thus, there is a clinical need to identify missense mutations through routine analysis to enable patient stratification. Sequencing is not widely

We investigated seven children from six families to expand the phenotypic spectrum associated with an early infantile epileptic encephalopathy caused by biallelic pathogenic variants in the phosphatidylinositol glycan anchor biosynthesis class Q (PIGQ) gene. The affected children were all identified by clinical or research exome sequencing. Clinical data, including EEGs and MRIs, was comprehensive

Whey powder rehydration is expected to be closely linked to both denaturation and lactosylation of the proteins. This study investigated the relation between the forced imbibition rate of spray-dried milk serum protein/lactose powders and the particle morphology and how it is related to the insoluble and lactosylated protein fraction, respectively. Despite extensive variation in protein denaturati

Calcareous nannofossils are considered to be the most productive calcifying organisms, but the impact of their emergence on the chemistry of the ocean in the Late Triassic is not understood yet. Evolutionary details of this bio-event are missing due to the scarcity of well-preserved outcrops worldwide. The current study focuses on the calcareous nannofossil assemblage of the middle Norian to lower

Background: Cardiac allograft vasculopathy (CAV) is characterized by diffuse thickening of the arterial intima. Statins reduce the incidence of CAV, but despite the use of statins, CAV remains one of the leading causes of long-term death after heart transplant. Inhibitors of proprotein convertase subtilisin-kexin type 9 (PCSK9) substantially reduce cholesterol levels but have not been tested in he

Eye movement research has shown that attention shifts from the currently fixated location to the next before a saccade is executed. We investigated whether the cost of the attention shift depends on higher-order processing at the time of fixation, in particular on visual working memory load differences between fixations and refixations on task-relevant items. The attention shift is reflected in EE

While urbanisation contributes to global biodiversity declines, flower-rich urban habitats may provide beneficial pollinator habitats. We investigated the potential of urban residential areas to contribute to pollinator diversity by analysing wild bee and hoverfly species richness and composition of species assemblages of summer-active species, sampled in 53 gardens across urban and rural landscap

This article examines the role of national parliaments in policy processes related to the realization of the 2030 Agenda for sustainable development, adopted in the UN General Assembly in 2015. We outline three main roles of parliaments in the case of national policy-making based on intergovernmental agreements: legislative and policy approval, citizen representation, and accountability. The cases

This work presents the results of a virtual reality (VR) experiment aiming at investigating how individual driving behaviour is affected by the presence of wildfire smoke. The experiment included a driving simulation task to study the chosen driving speed at different smoke densities and the lateral position of the driven car on the road cross section. During the VR experiment, participants were p

Operant conditioning chambers are used to perform a wide range of behavioral tests in the field of neuroscience. The recorded data is typically based on the triggering of lever and nose-poke sensors present inside the chambers. While this provides a detailed view of when and how animals perform certain responses, it cannot be used to evaluate behaviors that do not trigger any sensors. As such, ass

The extreme environments within the biosphere are inhabited by organisms known as extremophiles. Lately, these organisms are attracting a great deal of interest from researchers and industrialists. The motive behind this attraction is mainly related to the desire for new and efficient products of biotechnological importance and human curiosity of understanding nature. Organisms living in common “h

We present a simple reduction of the problem of nondecreasing paths (with minimal last edge weight) in a directed edge-weighted graph to a reachability problem in a directed unweighted graph. The reduction yields an alternative simple method of solving the single-source nondecreasing paths problem in almost linear time. If the edge weights are integers then our algorithm can be implemented in O((n

Aims and objectives: To reveal meanings of family members' lived experiences when a loved one undergoes an interhospital intensive care unit-to-unit transfer. Background: Interhospital intensive care unit-to-unit transfers take place between different hospitals and their respective intensive care units (ICUs). These types of transfers are an increasing phenomenon but are sparsely studied from the

Objectives: Implantable cardiac devices are common in patients with tetralogy of Fallot (ToF) (18.3–21.3%) according to previous reports from large centres. We conducted this study to investigate the prevalence and incidence of cardiac devices in a less selected population of patients with ToF and assess factors other than arrhythmia associated with having a device. Design: 530 adult (≥18 years) p

Summary: The existing information supports the use of this material as described in this safety assessment. 2,2-Dimethyl-3-methyl-3-butenyl propanoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog rhodinyl formate (CAS # 141-09-3)